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Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia.
Front Physiol 2018; 9:1470FP

Abstract

The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia.

Authors+Show Affiliations

Grupo Reproducción, Sede de Investigación Universitaria, Universidad de Antioquia, Medellín, Colombia.Grupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia.Grupo Reproducción, Sede de Investigación Universitaria, Universidad de Antioquia, Medellín, Colombia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30405431

Citation

Galvis-Ramírez, M F., et al. "Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia." Frontiers in Physiology, vol. 9, 2018, p. 1470.
Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sanchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front Physiol. 2018;9:1470.
Galvis-Ramírez, M. F., Quintana-Castillo, J. C., & Bueno-Sanchez, J. C. (2018). Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Frontiers in Physiology, 9, p. 1470. doi:10.3389/fphys.2018.01470.
Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sanchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front Physiol. 2018;9:1470. PubMed PMID: 30405431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. AU - Galvis-Ramírez,M F, AU - Quintana-Castillo,J C, AU - Bueno-Sanchez,J C, Y1 - 2018/10/23/ PY - 2018/06/26/received PY - 2018/09/28/accepted PY - 2018/11/9/entrez PY - 2018/11/9/pubmed PY - 2018/11/9/medline KW - glomerular endothelia dysfunction KW - heparan sulfate (HS) KW - preeclampsia KW - renal damage KW - systemic inflammatory response SP - 1470 EP - 1470 JF - Frontiers in physiology JO - Front Physiol VL - 9 N2 - The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia. SN - 1664-042X UR - https://www.unboundmedicine.com/medline/citation/30405431/Novel_Insights_Into_the_Role_of_Glycans_in_the_Pathophysiology_of_Glomerular_Endotheliosis_in_Preeclampsia L2 - https://dx.doi.org/10.3389/fphys.2018.01470 DB - PRIME DP - Unbound Medicine ER -