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Mitochondrial dynamics, a key executioner in neurodegenerative diseases.
Mitochondrion. 2019 07; 47:151-173.M

Abstract

Neurodegenerative diseases (NDs) are the group of disorder that includes brain, peripheral nerves, spinal cord and results in sensory and motor neuron dysfunction. Several studies have shown that mitochondrial dynamics and their axonal transport play a central role in most common NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and Amyotrophic Lateral Sclerosis (ALS) etc. In normal physiological condition, there is a balance between mitochondrial fission and fusion process while any alteration to these processes cause defect in ATP (Adenosine Triphosphate) biogenesis that lead to the onset of several NDs. Also, mitochondria mediated ROS may induce lipid and protein peroxidation, energy deficiency environment in the neurons and results in cell death and defective neurotransmission. Though, mitochondria is a well-studied cell organelle regulating the cellular energy demands but still, its detail role or association in NDs is under observation. In this review, we have summarized an updated mitochondria and their possible role in different NDs with the therapeutic strategy to improve the mitochondrial functions.

Authors+Show Affiliations

Genetics & Developmental Biology Laboratory, School of Biological Sciences & Biotechnology, Institute of Advanced Research (IAR), Koba, Institutional Area, Gandhinagar 382426, India.Genetics & Developmental Biology Laboratory, School of Biological Sciences & Biotechnology, Institute of Advanced Research (IAR), Koba, Institutional Area, Gandhinagar 382426, India. Electronic address: anandk.tiwari@iar.ac.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30408594

Citation

Panchal, Komal, and Anand Krishna Tiwari. "Mitochondrial Dynamics, a Key Executioner in Neurodegenerative Diseases." Mitochondrion, vol. 47, 2019, pp. 151-173.
Panchal K, Tiwari AK. Mitochondrial dynamics, a key executioner in neurodegenerative diseases. Mitochondrion. 2019;47:151-173.
Panchal, K., & Tiwari, A. K. (2019). Mitochondrial dynamics, a key executioner in neurodegenerative diseases. Mitochondrion, 47, 151-173. https://doi.org/10.1016/j.mito.2018.11.002
Panchal K, Tiwari AK. Mitochondrial Dynamics, a Key Executioner in Neurodegenerative Diseases. Mitochondrion. 2019;47:151-173. PubMed PMID: 30408594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial dynamics, a key executioner in neurodegenerative diseases. AU - Panchal,Komal, AU - Tiwari,Anand Krishna, Y1 - 2018/11/05/ PY - 2018/05/18/received PY - 2018/10/08/revised PY - 2018/11/02/accepted PY - 2018/11/9/pubmed PY - 2020/4/28/medline PY - 2018/11/9/entrez KW - ATP KW - Fission KW - Fusion KW - Mitochondrial dynamics KW - Neurodegenerative diseases KW - Oxidative stress SP - 151 EP - 173 JF - Mitochondrion JO - Mitochondrion VL - 47 N2 - Neurodegenerative diseases (NDs) are the group of disorder that includes brain, peripheral nerves, spinal cord and results in sensory and motor neuron dysfunction. Several studies have shown that mitochondrial dynamics and their axonal transport play a central role in most common NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and Amyotrophic Lateral Sclerosis (ALS) etc. In normal physiological condition, there is a balance between mitochondrial fission and fusion process while any alteration to these processes cause defect in ATP (Adenosine Triphosphate) biogenesis that lead to the onset of several NDs. Also, mitochondria mediated ROS may induce lipid and protein peroxidation, energy deficiency environment in the neurons and results in cell death and defective neurotransmission. Though, mitochondria is a well-studied cell organelle regulating the cellular energy demands but still, its detail role or association in NDs is under observation. In this review, we have summarized an updated mitochondria and their possible role in different NDs with the therapeutic strategy to improve the mitochondrial functions. SN - 1872-8278 UR - https://www.unboundmedicine.com/medline/citation/30408594/Mitochondrial_dynamics_a_key_executioner_in_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -