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A combined toxicokinetics and toxicodynamics approach to investigate delayed lead toxicity in the soil invertebrate Enchytraeus crypticus.
Ecotoxicol Environ Saf. 2019 Mar; 169:33-39.EE

Abstract

In a previous study, Pb toxicity was found to be delayed compared to Pb bioaccumulation in Enchytraeus crypticus. This study aimed at further investigating the acute and delayed onset of Pb toxicity in E. crypticus by using a combination of toxicokinetics and toxicodynamics approaches. Enchytraeids were exposed to different Pb concentrations (uptake phase) in natural LUFA 2.2 soil for different short-term exposure periods, followed by a 7-d elimination phase in clean soils. Body Pb concentrations and enchytraeid mortality were determined at different time intervals during both the exposure and the elimination phase. Pb uptake kinetics in E. crypticus were well described by a three-stage first-order model with an initial overshoot in body Pb concentrations. At higher exposure concentrations, Pb caused delayed enchytraeid mortality even following short-term exposure. LC50 based on body Pb concentrations appeared no good descriptor of delayed Pb toxicity in E. crypticus. Exposure time had a major impact on Pb bioaccumulation, toxicity and its delayed effects, which argues against relying on ecotoxicity tests for metal toxicity using a fix exposure duration. The presence of delayed toxic effects also suggests that post-exposure observations are necessary to avoid underestimation of metal toxicity.

Authors+Show Affiliations

Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands.Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands.Department of Ecological Science, Faculty of Science, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands. Electronic address: kees.van.gestel@vu.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30412896

Citation

Zhang, Lulu, et al. "A Combined Toxicokinetics and Toxicodynamics Approach to Investigate Delayed Lead Toxicity in the Soil Invertebrate Enchytraeus Crypticus." Ecotoxicology and Environmental Safety, vol. 169, 2019, pp. 33-39.
Zhang L, Belloc da Silva Muccillo V, Van Gestel CAM. A combined toxicokinetics and toxicodynamics approach to investigate delayed lead toxicity in the soil invertebrate Enchytraeus crypticus. Ecotoxicol Environ Saf. 2019;169:33-39.
Zhang, L., Belloc da Silva Muccillo, V., & Van Gestel, C. A. M. (2019). A combined toxicokinetics and toxicodynamics approach to investigate delayed lead toxicity in the soil invertebrate Enchytraeus crypticus. Ecotoxicology and Environmental Safety, 169, 33-39. https://doi.org/10.1016/j.ecoenv.2018.10.084
Zhang L, Belloc da Silva Muccillo V, Van Gestel CAM. A Combined Toxicokinetics and Toxicodynamics Approach to Investigate Delayed Lead Toxicity in the Soil Invertebrate Enchytraeus Crypticus. Ecotoxicol Environ Saf. 2019;169:33-39. PubMed PMID: 30412896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A combined toxicokinetics and toxicodynamics approach to investigate delayed lead toxicity in the soil invertebrate Enchytraeus crypticus. AU - Zhang,Lulu, AU - Belloc da Silva Muccillo,Victoria, AU - Van Gestel,Cornelis A M, Y1 - 2018/11/06/ PY - 2018/08/29/received PY - 2018/10/17/revised PY - 2018/10/23/accepted PY - 2018/11/10/pubmed PY - 2019/3/5/medline PY - 2018/11/10/entrez KW - Heavy metal KW - Oligochaeta KW - Post-exposure KW - Toxicity over time SP - 33 EP - 39 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 169 N2 - In a previous study, Pb toxicity was found to be delayed compared to Pb bioaccumulation in Enchytraeus crypticus. This study aimed at further investigating the acute and delayed onset of Pb toxicity in E. crypticus by using a combination of toxicokinetics and toxicodynamics approaches. Enchytraeids were exposed to different Pb concentrations (uptake phase) in natural LUFA 2.2 soil for different short-term exposure periods, followed by a 7-d elimination phase in clean soils. Body Pb concentrations and enchytraeid mortality were determined at different time intervals during both the exposure and the elimination phase. Pb uptake kinetics in E. crypticus were well described by a three-stage first-order model with an initial overshoot in body Pb concentrations. At higher exposure concentrations, Pb caused delayed enchytraeid mortality even following short-term exposure. LC50 based on body Pb concentrations appeared no good descriptor of delayed Pb toxicity in E. crypticus. Exposure time had a major impact on Pb bioaccumulation, toxicity and its delayed effects, which argues against relying on ecotoxicity tests for metal toxicity using a fix exposure duration. The presence of delayed toxic effects also suggests that post-exposure observations are necessary to avoid underestimation of metal toxicity. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/30412896/A_combined_toxicokinetics_and_toxicodynamics_approach_to_investigate_delayed_lead_toxicity_in_the_soil_invertebrate_Enchytraeus_crypticus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(18)31095-9 DB - PRIME DP - Unbound Medicine ER -
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