Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva.Methods Mol Biol. 2019; 1891:247-255.MM
Abstract
Fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder of progressive extra-skeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans. Most people with FOP carry an activating mutation in a BMP type I receptor gene, ACVR1 R206H, that promotes ectopic chondrogenesis and osteogenesis and in turn HO. Advances in elucidating the cellular and molecular events and mechanisms that lead to the ectopic bone formation are being made through the use of genetically engineered mouse models that recapitulate the human disease. We describe methods for inducing heterotopic ossification in a mouse model that conditionally expresses the Acvr1 R206H allele.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
30414138
Citation
Chakkalakal, Salin A., and Eileen M. Shore. "Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva." Methods in Molecular Biology (Clifton, N.J.), vol. 1891, 2019, pp. 247-255.
Chakkalakal SA, Shore EM. Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva. Methods Mol Biol. 2019;1891:247-255.
Chakkalakal, S. A., & Shore, E. M. (2019). Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva. Methods in Molecular Biology (Clifton, N.J.), 1891, 247-255. https://doi.org/10.1007/978-1-4939-8904-1_18
Chakkalakal SA, Shore EM. Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva. Methods Mol Biol. 2019;1891:247-255. PubMed PMID: 30414138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva.
AU - Chakkalakal,Salin A,
AU - Shore,Eileen M,
PY - 2018/11/11/entrez
PY - 2018/11/11/pubmed
PY - 2019/6/5/medline
KW - ACVR1
KW - ALK2
KW - FOP
KW - Fibrodysplasia ossificans progressiva
KW - HO
KW - Heterotopic ossification
KW - Mouse model
SP - 247
EP - 255
JF - Methods in molecular biology (Clifton, N.J.)
JO - Methods Mol Biol
VL - 1891
N2 - Fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder of progressive extra-skeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans. Most people with FOP carry an activating mutation in a BMP type I receptor gene, ACVR1 R206H, that promotes ectopic chondrogenesis and osteogenesis and in turn HO. Advances in elucidating the cellular and molecular events and mechanisms that lead to the ectopic bone formation are being made through the use of genetically engineered mouse models that recapitulate the human disease. We describe methods for inducing heterotopic ossification in a mouse model that conditionally expresses the Acvr1 R206H allele.
SN - 1940-6029
UR - https://www.unboundmedicine.com/medline/citation/30414138/Heterotopic_Ossification_in_Mouse_Models_of_Fibrodysplasia_Ossificans_Progressiva_
DB - PRIME
DP - Unbound Medicine
ER -