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Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease.
IUBMB Life. 2019 02; 71(2):277-282.IL

Abstract

This study aimed to detect the circulating oxidized low-density lipoprotein (ox-LDL) levels of controls and patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) and also to investigate the correlation with the severity of coronary heart disease (CHD). Plasma levels of circulating ox-LDL-4E6, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, apoprotein A, apoprotein B, and lipoprotein (a) (Lp(a)) were measured in 99 participants who underwent coronary angiography. The plasma ox-LDL level was significantly higher in patients with CHD than in controls (P = 0.000). However, it was lower in the UAP and AMI groups than in the SAP group (P = 0.000). The lipid peroxide level (MDA) showed a significant difference among all groups (P = 0.000). It increased significantly in patients with CHD. The Lp(a) and hs-CRP levels were significantly higher in patients with CHD (P = 0.000 and 0.000, respectively). No difference in Lp(a) was found among the SAP, UAP, and AMI groups (P = 0.296). In patients with CHD, the plasma ox-LDL correlated negatively with hs-CRP (P = 0.011), and serum MDA correlated positively with hs-CRP (P = 0.004). The plasma ox-LDL could be used as a strong risk factor for the early stage but not the advanced stage of CHD. Hs-CRP may bound and transfer ox-LDL to macrophages. © 2018 IUBMB Life, 71(1):277-282, 2019.

Authors+Show Affiliations

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin Province, China.Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin Province, China.Department of Radiology, The Second Hospital of Jilin University, Changchun, Jilin Province, China.Department of Ultrasound, The Second Hospital of Jilin University, Changchun, Jilin Province, China.Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30414358

Citation

Zhang, Qiang, et al. "Circulating Oxidized Low-Density Lipoprotein Is a Strong Risk Factor for the Early Stage of Coronary Heart Disease." IUBMB Life, vol. 71, no. 2, 2019, pp. 277-282.
Zhang Q, Ai Y, Dong H, et al. Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease. IUBMB Life. 2019;71(2):277-282.
Zhang, Q., Ai, Y., Dong, H., Wang, J., & Xu, L. (2019). Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease. IUBMB Life, 71(2), 277-282. https://doi.org/10.1002/iub.1966
Zhang Q, et al. Circulating Oxidized Low-Density Lipoprotein Is a Strong Risk Factor for the Early Stage of Coronary Heart Disease. IUBMB Life. 2019;71(2):277-282. PubMed PMID: 30414358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease. AU - Zhang,Qiang, AU - Ai,Yongshun, AU - Dong,Huiqiu, AU - Wang,Junsong, AU - Xu,Li, Y1 - 2018/11/10/ PY - 2018/08/30/received PY - 2018/09/29/revised PY - 2018/10/10/accepted PY - 2018/11/11/pubmed PY - 2020/1/14/medline PY - 2018/11/11/entrez KW - coronary angiography KW - coronary heart disease KW - oxidized low-density lipoprotein SP - 277 EP - 282 JF - IUBMB life JO - IUBMB Life VL - 71 IS - 2 N2 - This study aimed to detect the circulating oxidized low-density lipoprotein (ox-LDL) levels of controls and patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) and also to investigate the correlation with the severity of coronary heart disease (CHD). Plasma levels of circulating ox-LDL-4E6, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, apoprotein A, apoprotein B, and lipoprotein (a) (Lp(a)) were measured in 99 participants who underwent coronary angiography. The plasma ox-LDL level was significantly higher in patients with CHD than in controls (P = 0.000). However, it was lower in the UAP and AMI groups than in the SAP group (P = 0.000). The lipid peroxide level (MDA) showed a significant difference among all groups (P = 0.000). It increased significantly in patients with CHD. The Lp(a) and hs-CRP levels were significantly higher in patients with CHD (P = 0.000 and 0.000, respectively). No difference in Lp(a) was found among the SAP, UAP, and AMI groups (P = 0.296). In patients with CHD, the plasma ox-LDL correlated negatively with hs-CRP (P = 0.011), and serum MDA correlated positively with hs-CRP (P = 0.004). The plasma ox-LDL could be used as a strong risk factor for the early stage but not the advanced stage of CHD. Hs-CRP may bound and transfer ox-LDL to macrophages. © 2018 IUBMB Life, 71(1):277-282, 2019. SN - 1521-6551 UR - https://www.unboundmedicine.com/medline/citation/30414358/Circulating_Oxidized_Low_Density_Lipoprotein_is_a_Strong_Risk_Factor_for_the_Early_Stage_of_Coronary_Heart_Disease_ L2 - https://doi.org/10.1002/iub.1966 DB - PRIME DP - Unbound Medicine ER -