Tags

Type your tag names separated by a space and hit enter

Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions.
Int J Pharm. 2019 Jan 10; 554:190-200.IJ

Abstract

Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δp values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.

Authors+Show Affiliations

University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: jelena.djuris@pharmacy.bg.ac.rs.University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia.University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia.University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia.University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia.University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30414899

Citation

Djuris, Jelena, et al. "Selection of the Suitable Polymer for Supercritical Fluid Assisted Preparation of Carvedilol Solid Dispersions." International Journal of Pharmaceutics, vol. 554, 2019, pp. 190-200.
Djuris J, Milovanovic S, Medarevic D, et al. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. Int J Pharm. 2019;554:190-200.
Djuris, J., Milovanovic, S., Medarevic, D., Dobricic, V., Dapčević, A., & Ibric, S. (2019). Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. International Journal of Pharmaceutics, 554, 190-200. https://doi.org/10.1016/j.ijpharm.2018.11.015
Djuris J, et al. Selection of the Suitable Polymer for Supercritical Fluid Assisted Preparation of Carvedilol Solid Dispersions. Int J Pharm. 2019 Jan 10;554:190-200. PubMed PMID: 30414899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions. AU - Djuris,Jelena, AU - Milovanovic,Stoja, AU - Medarevic,Djordje, AU - Dobricic,Vladimir, AU - Dapčević,Aleksandra, AU - Ibric,Svetlana, Y1 - 2018/11/08/ PY - 2018/07/03/received PY - 2018/11/05/revised PY - 2018/11/07/accepted PY - 2018/11/12/pubmed PY - 2019/4/4/medline PY - 2018/11/12/entrez KW - Carvedilol KW - Improved dissolution KW - Solid dispersion KW - Supercritical CO(2) KW - Tabletability SP - 190 EP - 200 JF - International journal of pharmaceutics JO - Int J Pharm VL - 554 N2 - Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δp values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/30414899/Selection_of_the_suitable_polymer_for_supercritical_fluid_assisted_preparation_of_carvedilol_solid_dispersions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(18)30833-0 DB - PRIME DP - Unbound Medicine ER -