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Two new tetralone glycosides from the green walnut husks of Juglans mandshurica Maxim.
Nat Prod Res. 2019 Oct; 33(20):2932-2938.NP

Abstract

Two new tetralone glycosides, 4(S)-5-methoxy juglanoside A (1), 4(S)-5-methoxy juglanoside D (2), together with ten known compounds (3-12) have been isolated from the green walnut husks of Juglans mandshurica Maxim. Their structures were elucidated on the basis of their ESI-MS, 1 D and 2 D NMR spectroscopic data. In addition, all compounds were evaluated for their cytotoxic activities against the cancer BGC-823 (human gastric carcinoma), HCT-15 (human colorectal carcinoma) and K562 (human chronic myeloid leukemia) cell lines. The results showed aglycones of naphthoquinones had stronger cytotoxic activities than glycosides of tetralone.

Authors+Show Affiliations

a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.b Academic Research Department, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.a College of Pharmacy, Heilongjiang University of Chinese Medicine , Harbin , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30417677

Citation

Zhou, Yuan-Yuan, et al. "Two New Tetralone Glycosides From the Green Walnut Husks of Juglans Mandshurica Maxim." Natural Product Research, vol. 33, no. 20, 2019, pp. 2932-2938.
Zhou YY, Wang Y, Guo S, et al. Two new tetralone glycosides from the green walnut husks of Juglans mandshurica Maxim. Nat Prod Res. 2019;33(20):2932-2938.
Zhou, Y. Y., Wang, Y., Guo, S., Song, H. J., Zhang, X. J., Liu, Y., Yang, B. Y., & Kuang, H. X. (2019). Two new tetralone glycosides from the green walnut husks of Juglans mandshurica Maxim. Natural Product Research, 33(20), 2932-2938. https://doi.org/10.1080/14786419.2018.1510397
Zhou YY, et al. Two New Tetralone Glycosides From the Green Walnut Husks of Juglans Mandshurica Maxim. Nat Prod Res. 2019;33(20):2932-2938. PubMed PMID: 30417677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new tetralone glycosides from the green walnut husks of Juglans mandshurica Maxim. AU - Zhou,Yuan-Yuan, AU - Wang,Ying, AU - Guo,Shuang, AU - Song,Hong-Juan, AU - Zhang,Xiao-Juan, AU - Liu,Yan, AU - Yang,Bing-You, AU - Kuang,Hai-Xue, Y1 - 2018/11/10/ PY - 2018/11/13/pubmed PY - 2019/11/8/medline PY - 2018/11/13/entrez KW - Maxim KW - cytotoxicity KW - tetralone glycosides SP - 2932 EP - 2938 JF - Natural product research JO - Nat Prod Res VL - 33 IS - 20 N2 - Two new tetralone glycosides, 4(S)-5-methoxy juglanoside A (1), 4(S)-5-methoxy juglanoside D (2), together with ten known compounds (3-12) have been isolated from the green walnut husks of Juglans mandshurica Maxim. Their structures were elucidated on the basis of their ESI-MS, 1 D and 2 D NMR spectroscopic data. In addition, all compounds were evaluated for their cytotoxic activities against the cancer BGC-823 (human gastric carcinoma), HCT-15 (human colorectal carcinoma) and K562 (human chronic myeloid leukemia) cell lines. The results showed aglycones of naphthoquinones had stronger cytotoxic activities than glycosides of tetralone. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/30417677/Two_new_tetralone_glycosides_from_the_green_walnut_husks_of_Juglans_mandshurica_Maxim_ DB - PRIME DP - Unbound Medicine ER -