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Human-pathogenic Anaplasma spp., and Rickettsia spp. in animals in Xi'an, China.
PLoS Negl Trop Dis 2018; 12(11):e0006916PN

Abstract

In China, thirteen species of tick-borne rickettsiales bacteria pathogenic to human have been reported in ticks and host animals, and human patients caused by them also has been identified. However, investigation for rickettsiales bacteria circulating in Xi'an wasn't performed although diseases resembling human diseases caused by these organisms have been found. In this study, domestic animals and ticks in Xi'an, China, were tested for the presence of rickettsiales bacteria pathogenic to humans. Besides A. ovis, a high prevalence of A. capra was observed suggesting a high public health risk exists. In addition, two novel Anaplasma species closely related to A. phagocytophilum were identified and formed distinct lineages in the phylogenetic trees, with more than 98.3% identities for rrs gene, while divergences up to 20.2% and 37.0% for groEL and gltA genes, respectively. Both of these two novel Anaplasma species were found to circulate in goats and further assessment of their pathogenicity is needed. Ca. R. jingxinensis, with potential pathogenicity, was also detected in H. longicomis ticks with high prevalence. However, other causative agents were not identified although they were distributed in other areas of China.

Authors+Show Affiliations

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30419024

Citation

Guo, Wen-Ping, et al. "Human-pathogenic Anaplasma Spp., and Rickettsia Spp. in Animals in Xi'an, China." PLoS Neglected Tropical Diseases, vol. 12, no. 11, 2018, pp. e0006916.
Guo WP, Huang B, Zhao Q, et al. Human-pathogenic Anaplasma spp., and Rickettsia spp. in animals in Xi'an, China. PLoS Negl Trop Dis. 2018;12(11):e0006916.
Guo, W. P., Huang, B., Zhao, Q., Xu, G., Liu, B., Wang, Y. H., & Zhou, E. M. (2018). Human-pathogenic Anaplasma spp., and Rickettsia spp. in animals in Xi'an, China. PLoS Neglected Tropical Diseases, 12(11), pp. e0006916. doi:10.1371/journal.pntd.0006916.
Guo WP, et al. Human-pathogenic Anaplasma Spp., and Rickettsia Spp. in Animals in Xi'an, China. PLoS Negl Trop Dis. 2018;12(11):e0006916. PubMed PMID: 30419024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human-pathogenic Anaplasma spp., and Rickettsia spp. in animals in Xi'an, China. AU - Guo,Wen-Ping, AU - Huang,Baicheng, AU - Zhao,Qin, AU - Xu,Gang, AU - Liu,Baoyuan, AU - Wang,Yi-Han, AU - Zhou,En-Min, Y1 - 2018/11/12/ PY - 2018/07/18/received PY - 2018/10/10/accepted PY - 2018/11/26/revised PY - 2018/11/13/pubmed PY - 2019/1/18/medline PY - 2018/11/13/entrez SP - e0006916 EP - e0006916 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 12 IS - 11 N2 - In China, thirteen species of tick-borne rickettsiales bacteria pathogenic to human have been reported in ticks and host animals, and human patients caused by them also has been identified. However, investigation for rickettsiales bacteria circulating in Xi'an wasn't performed although diseases resembling human diseases caused by these organisms have been found. In this study, domestic animals and ticks in Xi'an, China, were tested for the presence of rickettsiales bacteria pathogenic to humans. Besides A. ovis, a high prevalence of A. capra was observed suggesting a high public health risk exists. In addition, two novel Anaplasma species closely related to A. phagocytophilum were identified and formed distinct lineages in the phylogenetic trees, with more than 98.3% identities for rrs gene, while divergences up to 20.2% and 37.0% for groEL and gltA genes, respectively. Both of these two novel Anaplasma species were found to circulate in goats and further assessment of their pathogenicity is needed. Ca. R. jingxinensis, with potential pathogenicity, was also detected in H. longicomis ticks with high prevalence. However, other causative agents were not identified although they were distributed in other areas of China. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/30419024/Human_pathogenic_Anaplasma_spp__and_Rickettsia_spp__in_animals_in_Xi'an_China_ L2 - http://dx.plos.org/10.1371/journal.pntd.0006916 DB - PRIME DP - Unbound Medicine ER -