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Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.
Int Immunopharmacol. 2019 Jan; 66:19-27.II

Abstract

Astilbin (AST), a dihydro-flavonol glycoside, is a major bioactive ingredient in Astilbe thunbergii, Engelhardia roxburghiana, Smilax corbularia and Erythroxylum gonocladum, and has been shown to have anti-inflammatory, antioxidative and neuroprotective effects, suggesting potential therapeutic value in the treatment of Parkinson's disease (PD). We explored the neuroprotective effects of AST in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mice. Mice were administered with MPTP (30 mg/kg, i.p) daily for 5 days, to establish a subacute Parkinson's disease model, followed by daily treatment with AST or saline for 7 days. Pole and traction tests showed that AST ameliorated the impaired motor functions in MPTP-induced Parkinson's disease mice. High performance liquid chromatography analysis revealed that AST treatment prevented MPTP-induced decreases in striatal dopamine levels. Immunofluorescence assays showed that AST reduced the loss of dopaminergic neurons and the activation of microglia and astrocytes in the substantia nigra. Western blot analyses revealed that AST suppressed α-synuclein overexpression and activated PI3K/Akt in the striatum following MPTP treatment. AST also prevented the MPTP-induced reduction in total superoxide dismutase and glutathione activity in the striatum. AST exerts neuroprotective effects on MPTP-induced PD mice by suppressing gliosis, α-synuclein overexpression and oxidative stress, suggesting that AST could serve as a therapeutic drug to ameliorate PD.

Authors+Show Affiliations

Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Yan'an Hospital of Traditional Chinese, Yan'an 716000, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China.Wuxi People's Hospital, Wuxi 214023, China.Wuxi Medical School, Jiangnan University, Wuxi 214122, China. Electronic address: shenyanqin@jiangnan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30419450

Citation

Zhu, Ying-Li, et al. "Neuroprotective Effects of Astilbin On MPTP-induced Parkinson's Disease Mice: Glial Reaction, Α-synuclein Expression and Oxidative Stress." International Immunopharmacology, vol. 66, 2019, pp. 19-27.
Zhu YL, Sun MF, Jia XB, et al. Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. Int Immunopharmacol. 2019;66:19-27.
Zhu, Y. L., Sun, M. F., Jia, X. B., Cheng, K., Xu, Y. D., Zhou, Z. L., Zhang, P. H., Qiao, C. M., Cui, C., Chen, X., Yang, X. S., & Shen, Y. Q. (2019). Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. International Immunopharmacology, 66, 19-27. https://doi.org/10.1016/j.intimp.2018.11.004
Zhu YL, et al. Neuroprotective Effects of Astilbin On MPTP-induced Parkinson's Disease Mice: Glial Reaction, Α-synuclein Expression and Oxidative Stress. Int Immunopharmacol. 2019;66:19-27. PubMed PMID: 30419450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. AU - Zhu,Ying-Li, AU - Sun,Meng-Fei, AU - Jia,Xue-Bing, AU - Cheng,Kun, AU - Xu,Yi-Da, AU - Zhou,Zhi-Lan, AU - Zhang,Pei-Hao, AU - Qiao,Chen-Meng, AU - Cui,Chun, AU - Chen,Xue, AU - Yang,Xu-Sheng, AU - Shen,Yan-Qin, Y1 - 2018/11/09/ PY - 2018/09/11/received PY - 2018/10/24/revised PY - 2018/11/05/accepted PY - 2018/11/13/pubmed PY - 2019/5/15/medline PY - 2018/11/13/entrez KW - Astilbin KW - Gliosis KW - MPTP KW - Neuroprotective KW - Oxidative stress KW - Parkinson's disease SP - 19 EP - 27 JF - International immunopharmacology JO - Int Immunopharmacol VL - 66 N2 - Astilbin (AST), a dihydro-flavonol glycoside, is a major bioactive ingredient in Astilbe thunbergii, Engelhardia roxburghiana, Smilax corbularia and Erythroxylum gonocladum, and has been shown to have anti-inflammatory, antioxidative and neuroprotective effects, suggesting potential therapeutic value in the treatment of Parkinson's disease (PD). We explored the neuroprotective effects of AST in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mice. Mice were administered with MPTP (30 mg/kg, i.p) daily for 5 days, to establish a subacute Parkinson's disease model, followed by daily treatment with AST or saline for 7 days. Pole and traction tests showed that AST ameliorated the impaired motor functions in MPTP-induced Parkinson's disease mice. High performance liquid chromatography analysis revealed that AST treatment prevented MPTP-induced decreases in striatal dopamine levels. Immunofluorescence assays showed that AST reduced the loss of dopaminergic neurons and the activation of microglia and astrocytes in the substantia nigra. Western blot analyses revealed that AST suppressed α-synuclein overexpression and activated PI3K/Akt in the striatum following MPTP treatment. AST also prevented the MPTP-induced reduction in total superoxide dismutase and glutathione activity in the striatum. AST exerts neuroprotective effects on MPTP-induced PD mice by suppressing gliosis, α-synuclein overexpression and oxidative stress, suggesting that AST could serve as a therapeutic drug to ameliorate PD. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/30419450/Neuroprotective_effects_of_Astilbin_on_MPTP_induced_Parkinson's_disease_mice:_Glial_reaction_α_synuclein_expression_and_oxidative_stress_ DB - PRIME DP - Unbound Medicine ER -