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The effect of exercise during pregnancy on gestational diabetes mellitus in normal-weight women: a systematic review and meta-analysis.
BMC Pregnancy Childbirth 2018; 18(1):440BP

Abstract

BACKGROUND

Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and it has both short- and long-term adverse effects on the health of mothers and fetuses. To investigate the effect of exercise during pregnancy on the occurrence of GDM among normal-weight pregnant women.

METHODS

We searched for studies published between January 1994 and June 2017 that appeared in the Web of Science, Scopus, ClinicalTrials.gov or Cochrane library databases. Randomized controlled trials that investigated the preventive effect of exercise on GDM in normal-weight women were included. Interventions including any confounding factors (e.g., dietary) were excluded. We extracted maternal characteristics, the diagnostic criteria of GDM, and basic information for intervention and obstetric outcomes. The primary outcome was the occurrence of GDM, and the secondary outcomes included gestational weight gain, gestational age at birth, birth weight, and the odds of cesarean section. A meta-analysis was conducted based on calculations of pooled estimates using the random-effects model.

RESULTS

Eight studies were included in this systematic review and meta-analysis. Exercise during pregnancy was shown to decrease the occurrence of GDM [RR = 0.58, 95% CI (0.37, 0.90), P = 0.01 and RR = 0.60, 95% CI (0.36, 0.98), P = 0.04 based on different diagnosis criteria, respectively] in normal-weight women. Regarding secondary outcomes, exercise during pregnancy can decrease gestational weight gain [MD = - 1.61, 95% CI (- 1.99, - 1.22), P<0.01], and had no significant effects on gestational age at birth [MD = - 0.55, 95% CI (- 1.57, 0.47), P = 0.29], birth weight [MD = - 18.70, 95% CI (- 52.49, 15.08), P = 0.28], and the odds of caesarean section [RR = 0.88, 95% CI (0.72, 1.08), P = 0.21], respectively.

CONCLUSIONS

Exercise during pregnancy can ostensibly decrease the occurrence of GDM without reducing gestational age at delivery and increasing the odds of cesarean section in normal-weight women.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Harvard Medical School, Harvard University, Boston, MA, USA. Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.School of Public Health, The University of Hong Kong, Hong Kong, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wangzil@mail.sysu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30419848

Citation

Ming, Wai-Kit, et al. "The Effect of Exercise During Pregnancy On Gestational Diabetes Mellitus in Normal-weight Women: a Systematic Review and Meta-analysis." BMC Pregnancy and Childbirth, vol. 18, no. 1, 2018, p. 440.
Ming WK, Ding W, Zhang CJP, et al. The effect of exercise during pregnancy on gestational diabetes mellitus in normal-weight women: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18(1):440.
Ming, W. K., Ding, W., Zhang, C. J. P., Zhong, L., Long, Y., Li, Z., ... Wang, Z. (2018). The effect of exercise during pregnancy on gestational diabetes mellitus in normal-weight women: a systematic review and meta-analysis. BMC Pregnancy and Childbirth, 18(1), p. 440. doi:10.1186/s12884-018-2068-7.
Ming WK, et al. The Effect of Exercise During Pregnancy On Gestational Diabetes Mellitus in Normal-weight Women: a Systematic Review and Meta-analysis. BMC Pregnancy Childbirth. 2018 Nov 12;18(1):440. PubMed PMID: 30419848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of exercise during pregnancy on gestational diabetes mellitus in normal-weight women: a systematic review and meta-analysis. AU - Ming,Wai-Kit, AU - Ding,Wenjing, AU - Zhang,Casper J P, AU - Zhong,Lieqiang, AU - Long,Yuhang, AU - Li,Zhuyu, AU - Sun,Cong, AU - Wu,Yanxin, AU - Chen,Hanqing, AU - Chen,Haitian, AU - Wang,Zilian, Y1 - 2018/11/12/ PY - 2018/04/07/received PY - 2018/10/19/accepted PY - 2018/11/14/entrez PY - 2018/11/14/pubmed PY - 2019/2/28/medline KW - Exercise KW - Gestational diabetes mellitus KW - Meta-analysis KW - Systematic review SP - 440 EP - 440 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 18 IS - 1 N2 - BACKGROUND: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and it has both short- and long-term adverse effects on the health of mothers and fetuses. To investigate the effect of exercise during pregnancy on the occurrence of GDM among normal-weight pregnant women. METHODS: We searched for studies published between January 1994 and June 2017 that appeared in the Web of Science, Scopus, ClinicalTrials.gov or Cochrane library databases. Randomized controlled trials that investigated the preventive effect of exercise on GDM in normal-weight women were included. Interventions including any confounding factors (e.g., dietary) were excluded. We extracted maternal characteristics, the diagnostic criteria of GDM, and basic information for intervention and obstetric outcomes. The primary outcome was the occurrence of GDM, and the secondary outcomes included gestational weight gain, gestational age at birth, birth weight, and the odds of cesarean section. A meta-analysis was conducted based on calculations of pooled estimates using the random-effects model. RESULTS: Eight studies were included in this systematic review and meta-analysis. Exercise during pregnancy was shown to decrease the occurrence of GDM [RR = 0.58, 95% CI (0.37, 0.90), P = 0.01 and RR = 0.60, 95% CI (0.36, 0.98), P = 0.04 based on different diagnosis criteria, respectively] in normal-weight women. Regarding secondary outcomes, exercise during pregnancy can decrease gestational weight gain [MD = - 1.61, 95% CI (- 1.99, - 1.22), P<0.01], and had no significant effects on gestational age at birth [MD = - 0.55, 95% CI (- 1.57, 0.47), P = 0.29], birth weight [MD = - 18.70, 95% CI (- 52.49, 15.08), P = 0.28], and the odds of caesarean section [RR = 0.88, 95% CI (0.72, 1.08), P = 0.21], respectively. CONCLUSIONS: Exercise during pregnancy can ostensibly decrease the occurrence of GDM without reducing gestational age at delivery and increasing the odds of cesarean section in normal-weight women. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/30419848/The_effect_of_exercise_during_pregnancy_on_gestational_diabetes_mellitus_in_normal_weight_women:_a_systematic_review_and_meta_analysis_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-018-2068-7 DB - PRIME DP - Unbound Medicine ER -