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CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes.
Cytokine 2019; 114:81-85C

Abstract

AIM

In the currently available literature there are no works investigating the correlation between CCR5-Δ32 polymorphism and dyslipidemia in children with type 1 diabetes mellitus (T1D). Therefore, we have decided to explore the potential role played by this polymorphic locus in the incidence of dyslipidemia as an important risk factor for cardiovascular disease (CVD) in patients with T1D.

METHODS

A total of 380 patients with T1D were selected. Patients were divided into two groups: 180 patients with diabetic dyslipidemia and 200 controls without dyslipidemia. Characterization of CCR5-Δ32 genotypes was analyzed by polymerase chain reaction. Logistic regression model was used to examine the association between CCR5-Δ32 polymorphism and dyslipidemia.

RESULTS

When participants were analyzed according to CCR5-Δ32 polymorphism, Δ32 carriers presented higher levels of: HbA1c (p < 0.001), fasting plasma glucose (p < 0.001), LDL (p = 0.02) as well as TG (p = 0.01) and lower levels of HDL (p = 0.01) than noncarriers. Moreover, the minor allele Δ32 was more frequent in dyslipidemic subjects than controls (p < 0.001) and conferred an increased individual risk for dyslipidemia (OR = 2.327; 95% CI = 11.241-4.365; p = 0.009).

CONCLUSIONS

The findings of our study suggest that the CCR5-Δ32 polymorphism is associated with elevated plasma lipid levels and the Δ32 allele increases the risk of dyslipidemia in patients with T1D. Identification of the functional variant underlying these associations may potentially lead to the development of a novel and adjunctive approach for the treatment of dyslipidemia and CVD.

Authors+Show Affiliations

Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland. Electronic address: bartosz@gumed.edu.pl.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30420202

Citation

Słomiński, Bartosz, et al. "CCR5-Δ32 Polymorphism Is a Genetic Risk Factor Associated With Dyslipidemia in Patients With Type 1 Diabetes." Cytokine, vol. 114, 2019, pp. 81-85.
Słomiński B, Ławrynowicz U, Ryba-Stanisławowska M, et al. CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes. Cytokine. 2019;114:81-85.
Słomiński, B., Ławrynowicz, U., Ryba-Stanisławowska, M., Skrzypkowska, M., Myśliwska, J., & Myśliwiec, M. (2019). CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes. Cytokine, 114, pp. 81-85. doi:10.1016/j.cyto.2018.11.005.
Słomiński B, et al. CCR5-Δ32 Polymorphism Is a Genetic Risk Factor Associated With Dyslipidemia in Patients With Type 1 Diabetes. Cytokine. 2019;114:81-85. PubMed PMID: 30420202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CCR5-Δ32 polymorphism is a genetic risk factor associated with dyslipidemia in patients with type 1 diabetes. AU - Słomiński,Bartosz, AU - Ławrynowicz,Urszula, AU - Ryba-Stanisławowska,Monika, AU - Skrzypkowska,Maria, AU - Myśliwska,Jolanta, AU - Myśliwiec,Małgorzata, Y1 - 2018/11/09/ PY - 2018/01/15/received PY - 2018/10/18/revised PY - 2018/11/05/accepted PY - 2018/11/14/pubmed PY - 2018/11/14/medline PY - 2018/11/14/entrez KW - CCR5-Δ32 polymorphism KW - Cardiovascular diseases KW - Dyslipidemia KW - Type 1 diabetes mellitus SP - 81 EP - 85 JF - Cytokine JO - Cytokine VL - 114 N2 - AIM: In the currently available literature there are no works investigating the correlation between CCR5-Δ32 polymorphism and dyslipidemia in children with type 1 diabetes mellitus (T1D). Therefore, we have decided to explore the potential role played by this polymorphic locus in the incidence of dyslipidemia as an important risk factor for cardiovascular disease (CVD) in patients with T1D. METHODS: A total of 380 patients with T1D were selected. Patients were divided into two groups: 180 patients with diabetic dyslipidemia and 200 controls without dyslipidemia. Characterization of CCR5-Δ32 genotypes was analyzed by polymerase chain reaction. Logistic regression model was used to examine the association between CCR5-Δ32 polymorphism and dyslipidemia. RESULTS: When participants were analyzed according to CCR5-Δ32 polymorphism, Δ32 carriers presented higher levels of: HbA1c (p < 0.001), fasting plasma glucose (p < 0.001), LDL (p = 0.02) as well as TG (p = 0.01) and lower levels of HDL (p = 0.01) than noncarriers. Moreover, the minor allele Δ32 was more frequent in dyslipidemic subjects than controls (p < 0.001) and conferred an increased individual risk for dyslipidemia (OR = 2.327; 95% CI = 11.241-4.365; p = 0.009). CONCLUSIONS: The findings of our study suggest that the CCR5-Δ32 polymorphism is associated with elevated plasma lipid levels and the Δ32 allele increases the risk of dyslipidemia in patients with T1D. Identification of the functional variant underlying these associations may potentially lead to the development of a novel and adjunctive approach for the treatment of dyslipidemia and CVD. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/30420202/CCR5_Δ32_polymorphism_is_a_genetic_risk_factor_associated_with_dyslipidemia_in_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(18)30417-4 DB - PRIME DP - Unbound Medicine ER -