TY - JOUR T1 - Immune checkpoint inhibitors in the management of malignancies in transplant recipients. AU - Regalla,Dileep Kumar Reddy, AU - Williams,Grant R, AU - Paluri,Ravi Kumar, Y1 - 2018/11/13/ PY - 2018/08/27/received PY - 2018/10/10/revised PY - 2018/10/16/accepted PY - 2018/11/15/pubmed PY - 2019/2/9/medline PY - 2018/11/15/entrez KW - CTLA-4 KW - PD-1 KW - immune checkpoint inhibitors KW - malignancy KW - monoclonal antibodies KW - solid organ transplant SP - 704 EP - 708 JF - Postgraduate medical journal JO - Postgrad Med J VL - 94 IS - 1118 N2 - Cancer immunotherapy, an area of active research, has thus far yielded several exciting breakthroughs in cancer treatment strategies. So far, immune checkpoint inhibitors have been the most promising method of cancer immunotherapy. CTLA-4, PD-1 and PD-L1 are the immune checkpoint molecules against which monoclonal antibodies act against and revolutionised the treatment of several malignancies. However, it is still unclear whether using these monoclonal antibodies in patients with malignancy and a history of transplant is as beneficial as in patients without a history of transplantation. The reason being, with the therapeutic benefit, also comes the inherent disadvantage of transplant rejection because of the activation of T-cells against donor antigens. So, transplant-related complications limit the usage of the checkpoint blockade therapy to treat malignancies. Here, we review the data published in this context and suggest optimal approaches to using the currently available repertoire of immunotherapies. SN - 1469-0756 UR - https://www.unboundmedicine.com/medline/citation/30425139/Immune_checkpoint_inhibitors_in_the_management_of_malignancies_in_transplant_recipients_ DB - PRIME DP - Unbound Medicine ER -