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Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis.
Behav Neurol. 2018; 2018:2635202.BN

Abstract

Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS. Twenty-one consecutive ALS patients, in King's clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination. Between-group comparisons did not show any significant difference on cognitive and behavioral variables. When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p < .05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices. Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p < .05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS. Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment.

Authors+Show Affiliations

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy. Department of Psychology, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Psychology, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Salerno, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences; MRI Research Center SUN-FISM, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.Department of Psychology, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30425751

Citation

Femiano, Cinzia, et al. "Apathy Is Correlated With Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis." Behavioural Neurology, vol. 2018, 2018, p. 2635202.
Femiano C, Trojsi F, Caiazzo G, et al. Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behav Neurol. 2018;2018:2635202.
Femiano, C., Trojsi, F., Caiazzo, G., Siciliano, M., Passaniti, C., Russo, A., Bisecco, A., Cirillo, M., Monsurrò, M. R., Esposito, F., Tedeschi, G., & Santangelo, G. (2018). Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behavioural Neurology, 2018, 2635202. https://doi.org/10.1155/2018/2635202
Femiano C, et al. Apathy Is Correlated With Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behav Neurol. 2018;2018:2635202. PubMed PMID: 30425751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. AU - Femiano,Cinzia, AU - Trojsi,Francesca, AU - Caiazzo,Giuseppina, AU - Siciliano,Mattia, AU - Passaniti,Carla, AU - Russo,Antonio, AU - Bisecco,Alvino, AU - Cirillo,Mario, AU - Monsurrò,Maria Rosaria, AU - Esposito,Fabrizio, AU - Tedeschi,Gioacchino, AU - Santangelo,Gabriella, Y1 - 2018/10/22/ PY - 2018/04/22/received PY - 2018/08/06/revised PY - 2018/09/12/accepted PY - 2018/11/15/entrez PY - 2018/11/15/pubmed PY - 2019/4/16/medline SP - 2635202 EP - 2635202 JF - Behavioural neurology JO - Behav Neurol VL - 2018 N2 - Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS. Twenty-one consecutive ALS patients, in King's clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination. Between-group comparisons did not show any significant difference on cognitive and behavioral variables. When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p < .05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices. Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p < .05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS. Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment. SN - 1875-8584 UR - https://www.unboundmedicine.com/medline/citation/30425751/Apathy_Is_Correlated_with_Widespread_Diffusion_Tensor_Imaging__DTI__Impairment_in_Amyotrophic_Lateral_Sclerosis_ L2 - https://dx.doi.org/10.1155/2018/2635202 DB - PRIME DP - Unbound Medicine ER -