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Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China.
Int J Cancer 2019; 144(11):2644-2650IJ

Abstract

Acute kidney injury (AKI) is a common complication in cancer patients, but the data are lacking in Asian countries. We aimed to assed the epidemiology, correlated risk factors and outcomes of AKI in cancer patients from China. We conducted a nationwide cohort study of cancer patients who were admitted to 25 general and children hospitals across China from January 1, 2013 to December 31, 2015. We obtained patient-level data from the electronic hospitalization information system and laboratory databases of all inpatients who had at least two serum creatinine tests within any 7-day window during their first 30 days of hospitalization. AKI was defined and staged according to Kidney Disease Improving Global Outcomes criteria. Incidence rate and risk factor profiles for AKI were examined. Outcomes of interest included in-hospital mortality, length of stay and daily costs. A total of 136,756 adult cancer patients were assessed in our study. The overall incidence of AKI was 7.5%, of which 1.6% were community acquired and 5.9% hospital acquired. The top three cancer types with high incidence of AKI were bladder cancer, leukemia, and lymphoma. Risk factors for community-acquired and hospital-acquired AKI were similar, including age, increased baseline serum creatinine, shock and urinary tract obstruction. In-hospital death occurred in 12.0% with AKI vs. 0.9% cancer patients without AKI. After adjustment for confounders, the severe AKI was associated with higher risk of in-hospital death, prolonged length of stay and higher daily costs. Clinicians should increase their awareness of AKI in hospitalized cancer patients.

Authors+Show Affiliations

Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30426496

Citation

Cheng, Yichun, et al. "Epidemiology and Outcomes of Acute Kidney Injury in Hospitalized Cancer Patients in China." International Journal of Cancer, vol. 144, no. 11, 2019, pp. 2644-2650.
Cheng Y, Nie S, Li L, et al. Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China. Int J Cancer. 2019;144(11):2644-2650.
Cheng, Y., Nie, S., Li, L., Li, Y., Liu, D., Xiong, M., ... Xu, G. (2019). Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China. International Journal of Cancer, 144(11), pp. 2644-2650. doi:10.1002/ijc.31993.
Cheng Y, et al. Epidemiology and Outcomes of Acute Kidney Injury in Hospitalized Cancer Patients in China. Int J Cancer. 2019 06 1;144(11):2644-2650. PubMed PMID: 30426496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China. AU - Cheng,Yichun, AU - Nie,Sheng, AU - Li,Lu, AU - Li,Yanqin, AU - Liu,Diankun, AU - Xiong,Mengqi, AU - Wang,Long, AU - Ge,Shuwang, AU - Xu,Gang, AU - ,, Y1 - 2019/01/03/ PY - 2018/05/22/received PY - 2018/09/28/revised PY - 2018/10/30/accepted PY - 2018/11/15/pubmed PY - 2019/9/4/medline PY - 2018/11/15/entrez KW - KDIGO AKI criteria KW - acute kidney injury KW - cancer patients KW - incidence SP - 2644 EP - 2650 JF - International journal of cancer JO - Int. J. Cancer VL - 144 IS - 11 N2 - Acute kidney injury (AKI) is a common complication in cancer patients, but the data are lacking in Asian countries. We aimed to assed the epidemiology, correlated risk factors and outcomes of AKI in cancer patients from China. We conducted a nationwide cohort study of cancer patients who were admitted to 25 general and children hospitals across China from January 1, 2013 to December 31, 2015. We obtained patient-level data from the electronic hospitalization information system and laboratory databases of all inpatients who had at least two serum creatinine tests within any 7-day window during their first 30 days of hospitalization. AKI was defined and staged according to Kidney Disease Improving Global Outcomes criteria. Incidence rate and risk factor profiles for AKI were examined. Outcomes of interest included in-hospital mortality, length of stay and daily costs. A total of 136,756 adult cancer patients were assessed in our study. The overall incidence of AKI was 7.5%, of which 1.6% were community acquired and 5.9% hospital acquired. The top three cancer types with high incidence of AKI were bladder cancer, leukemia, and lymphoma. Risk factors for community-acquired and hospital-acquired AKI were similar, including age, increased baseline serum creatinine, shock and urinary tract obstruction. In-hospital death occurred in 12.0% with AKI vs. 0.9% cancer patients without AKI. After adjustment for confounders, the severe AKI was associated with higher risk of in-hospital death, prolonged length of stay and higher daily costs. Clinicians should increase their awareness of AKI in hospitalized cancer patients. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/30426496/Epidemiology_and_outcomes_of_acute_kidney_injury_in_hospitalized_cancer_patients_in_China_ DB - PRIME DP - Unbound Medicine ER -