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Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth.
Environ Sci Technol. 2019 01 02; 53(1):422-433.ES

Abstract

Parabens are potential endocrine disruptors with short half-lives in the human body. To date, few epidemiological studies regarding repeated paraben measurements during pregnancy associated with fetal and childhood growth have been conducted. Within a Chinese prenatal cohort, 850 mother-infant pairs from whom a complete set of maternal urine samples were acquired during three trimesters were included, and the levels of five parabens were measured. We assessed the associations of both average and trimester-specific urinary paraben levels with weight and height z-scores at birth, 6 months, 1, and 2 years of age. In all infants, each doubling increase in average ethyl paraben (EtP) was associated with -2.82% (95% CI: -5.11%, -0.53%) decrease in weight z-score at birth, whereas no significant age-specific associations were identified. After stratifying by sex, we further observed age-specific association of average EtP with -3.96% (95% CI: -7.03%, -0.89%) and -3.38% (95% CI: 6.72%, -0.03%) reduction in weight z-scores at 1 and 2 years in males, respectively. Third-trimester EtP was negatively associated with weight z-scores at birth, 1 and 2 years in males. Our results suggested negative associations between prenatal paraben exposure and fetal and childhood growth, and the third trimester may be the window of susceptibility.

Authors+Show Affiliations

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry , Hong Kong Baptist University , Hong Kong, SAR , People's Republic of China.Women and Children Medical and Healthcare Center of Wuhan , Wuhan , Hubei 430074 , People's Republic of China.Department of Epidemiology , Brown University , Providence , Rhode Island 02912 , United States.Women and Children Medical and Healthcare Center of Wuhan , Wuhan , Hubei 430074 , People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry , Hong Kong Baptist University , Hong Kong, SAR , People's Republic of China.Department of Occupational and Environmental Health, College of Public Health , Zhengzhou University , Zhengzhou , Henan 450001 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430030 , People's Republic of China.State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry , Hong Kong Baptist University , Hong Kong, SAR , People's Republic of China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430074 , People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30427191

Citation

Wu, Chuansha, et al. "Repeated Measurements of Paraben Exposure During Pregnancy in Relation to Fetal and Early Childhood Growth." Environmental Science & Technology, vol. 53, no. 1, 2019, pp. 422-433.
Wu C, Xia W, Li Y, et al. Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth. Environ Sci Technol. 2019;53(1):422-433.
Wu, C., Xia, W., Li, Y., Li, J., Zhang, B., Zheng, T., Zhou, A., Zhao, H., Huo, W., Hu, J., Jiang, M., Hu, C., Liao, J., Chen, X., Xu, B., Lu, S., Cai, Z., & Xu, S. (2019). Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth. Environmental Science & Technology, 53(1), 422-433. https://doi.org/10.1021/acs.est.8b01857
Wu C, et al. Repeated Measurements of Paraben Exposure During Pregnancy in Relation to Fetal and Early Childhood Growth. Environ Sci Technol. 2019 01 2;53(1):422-433. PubMed PMID: 30427191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth. AU - Wu,Chuansha, AU - Xia,Wei, AU - Li,Yuanyuan, AU - Li,Jiufeng, AU - Zhang,Bin, AU - Zheng,Tongzhang, AU - Zhou,Aifen, AU - Zhao,Hongzhi, AU - Huo,Wenqian, AU - Hu,Jie, AU - Jiang,Minmin, AU - Hu,Chen, AU - Liao,Jiaqiang, AU - Chen,Xi, AU - Xu,Bing, AU - Lu,Shi, AU - Cai,Zongwei, AU - Xu,Shunqing, Y1 - 2018/12/11/ PY - 2018/11/15/pubmed PY - 2019/9/19/medline PY - 2018/11/15/entrez SP - 422 EP - 433 JF - Environmental science & technology JO - Environ. Sci. Technol. VL - 53 IS - 1 N2 - Parabens are potential endocrine disruptors with short half-lives in the human body. To date, few epidemiological studies regarding repeated paraben measurements during pregnancy associated with fetal and childhood growth have been conducted. Within a Chinese prenatal cohort, 850 mother-infant pairs from whom a complete set of maternal urine samples were acquired during three trimesters were included, and the levels of five parabens were measured. We assessed the associations of both average and trimester-specific urinary paraben levels with weight and height z-scores at birth, 6 months, 1, and 2 years of age. In all infants, each doubling increase in average ethyl paraben (EtP) was associated with -2.82% (95% CI: -5.11%, -0.53%) decrease in weight z-score at birth, whereas no significant age-specific associations were identified. After stratifying by sex, we further observed age-specific association of average EtP with -3.96% (95% CI: -7.03%, -0.89%) and -3.38% (95% CI: 6.72%, -0.03%) reduction in weight z-scores at 1 and 2 years in males, respectively. Third-trimester EtP was negatively associated with weight z-scores at birth, 1 and 2 years in males. Our results suggested negative associations between prenatal paraben exposure and fetal and childhood growth, and the third trimester may be the window of susceptibility. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/30427191/Repeated_Measurements_of_Paraben_Exposure_during_Pregnancy_in_Relation_to_Fetal_and_Early_Childhood_Growth_ L2 - https://dx.doi.org/10.1021/acs.est.8b01857 DB - PRIME DP - Unbound Medicine ER -