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The associations among Helicobacter pylori infection, white blood cell count and nonalcoholic fatty liver disease in a large Chinese population.
Medicine (Baltimore). 2018 Nov; 97(46):e13271.M

Abstract

Reported relationships among Helicobacter pylori infection, white blood cell (WBC) count and nonalcoholic fatty liver disease (NAFLD) are inconsistent and controversial. We, therefore, conducted a cross-sectional study to investigate the associations among the presence of NAFLD, WBC count and H pylori infection, as diagnosed using the C-urea breath test (UBT).This study included 20,389 subjects enrolled at the International Health Care Center of the Second Affiliated Hospital of the Zhejiang University School of Medicine from January 2015 to December 2015. All participants underwent a C-UBT for the diagnosis of H pylori infection and ultrasonography for NAFLD as well as a blood test to determine WBC count. Multivariate logistic regression was then performed to evaluate the relationship among H pylori infection, WBC count and NAFLD.H pylori infection was detected in 38.49% (7,848/20,389) of the subjects via the UBT, and NAFLD was present in 37.24% (7,592/20,389) of the subjects. The prevalence of H pylori infection was higher in the NAFLD group than in the control group (41.25% vs 36.85%, P <.001). Significant differences were found between various WBC quartiles and H pylori infection, age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-sensitivity C-reactive protein (HS-CRP), glycosylated hemoglobin (HbA1c), triglyceride (TG), low-density lipoprotein (LDL-C), fasting blood glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), and smoking. Multivariate logistic regression revealed that the combination of H pylori infection and WBC count (odds ratio [OR] = 1.067, 95% confidence interval [CI]: 1.014, 1.093; P = .007; OR = 1.165, 95% CI: 1.023, 1.488; P <.001; OR = 1.183, 95% CI: 1.085, 1.559; P <.001, respectively) was positively associated with NAFLD.H pylori infection and WBC count may contribute to the pathogenesis of NAFLD.

Authors+Show Affiliations

International Health Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou.Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.International Health Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou.International Health Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou.International Health Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

30431613

Citation

Yu, Ying-Ying, et al. "The Associations Among Helicobacter Pylori Infection, White Blood Cell Count and Nonalcoholic Fatty Liver Disease in a Large Chinese Population." Medicine, vol. 97, no. 46, 2018, pp. e13271.
Yu YY, Cai JT, Song ZY, et al. The associations among Helicobacter pylori infection, white blood cell count and nonalcoholic fatty liver disease in a large Chinese population. Medicine (Baltimore). 2018;97(46):e13271.
Yu, Y. Y., Cai, J. T., Song, Z. Y., Tong, Y. L., & Wang, J. H. (2018). The associations among Helicobacter pylori infection, white blood cell count and nonalcoholic fatty liver disease in a large Chinese population. Medicine, 97(46), e13271. https://doi.org/10.1097/MD.0000000000013271
Yu YY, et al. The Associations Among Helicobacter Pylori Infection, White Blood Cell Count and Nonalcoholic Fatty Liver Disease in a Large Chinese Population. Medicine (Baltimore). 2018;97(46):e13271. PubMed PMID: 30431613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations among Helicobacter pylori infection, white blood cell count and nonalcoholic fatty liver disease in a large Chinese population. AU - Yu,Ying-Ying, AU - Cai,Jian-Ting, AU - Song,Zhen-Ya, AU - Tong,Yu-Ling, AU - Wang,Jing-Hua, PY - 2018/11/16/entrez PY - 2018/11/16/pubmed PY - 2018/11/27/medline SP - e13271 EP - e13271 JF - Medicine JO - Medicine (Baltimore) VL - 97 IS - 46 N2 - Reported relationships among Helicobacter pylori infection, white blood cell (WBC) count and nonalcoholic fatty liver disease (NAFLD) are inconsistent and controversial. We, therefore, conducted a cross-sectional study to investigate the associations among the presence of NAFLD, WBC count and H pylori infection, as diagnosed using the C-urea breath test (UBT).This study included 20,389 subjects enrolled at the International Health Care Center of the Second Affiliated Hospital of the Zhejiang University School of Medicine from January 2015 to December 2015. All participants underwent a C-UBT for the diagnosis of H pylori infection and ultrasonography for NAFLD as well as a blood test to determine WBC count. Multivariate logistic regression was then performed to evaluate the relationship among H pylori infection, WBC count and NAFLD.H pylori infection was detected in 38.49% (7,848/20,389) of the subjects via the UBT, and NAFLD was present in 37.24% (7,592/20,389) of the subjects. The prevalence of H pylori infection was higher in the NAFLD group than in the control group (41.25% vs 36.85%, P <.001). Significant differences were found between various WBC quartiles and H pylori infection, age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-sensitivity C-reactive protein (HS-CRP), glycosylated hemoglobin (HbA1c), triglyceride (TG), low-density lipoprotein (LDL-C), fasting blood glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), and smoking. Multivariate logistic regression revealed that the combination of H pylori infection and WBC count (odds ratio [OR] = 1.067, 95% confidence interval [CI]: 1.014, 1.093; P = .007; OR = 1.165, 95% CI: 1.023, 1.488; P <.001; OR = 1.183, 95% CI: 1.085, 1.559; P <.001, respectively) was positively associated with NAFLD.H pylori infection and WBC count may contribute to the pathogenesis of NAFLD. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/30431613/The_associations_among_Helicobacter_pylori_infection_white_blood_cell_count_and_nonalcoholic_fatty_liver_disease_in_a_large_Chinese_population_ L2 - https://doi.org/10.1097/MD.0000000000013271 DB - PRIME DP - Unbound Medicine ER -