Citation
Shalhoub, Sarah, et al. "Critically Ill Healthcare Workers With the Middle East Respiratory Syndrome (MERS): a Multicenter Study." PloS One, vol. 13, no. 11, 2018, pp. e0206831.
Shalhoub S, Al-Hameed F, Mandourah Y, et al. Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study. PLoS One. 2018;13(11):e0206831.
Shalhoub, S., Al-Hameed, F., Mandourah, Y., Balkhy, H. H., Al-Omari, A., Al Mekhlafi, G. A., Kharaba, A., Alraddadi, B., Almotairi, A., Al Khatib, K., Abdulmomen, A., Qushmaq, I., Mady, A., Solaiman, O., Al-Aithan, A. M., Al-Raddadi, R., Ragab, A., Al Harthy, A., Al Qasim, E., ... Arabi, Y. M. (2018). Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study. PloS One, 13(11), e0206831. https://doi.org/10.1371/journal.pone.0206831
Shalhoub S, et al. Critically Ill Healthcare Workers With the Middle East Respiratory Syndrome (MERS): a Multicenter Study. PLoS One. 2018;13(11):e0206831. PubMed PMID: 30439974.
TY - JOUR
T1 - Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study.
AU - Shalhoub,Sarah,
AU - Al-Hameed,Fahad,
AU - Mandourah,Yasser,
AU - Balkhy,Hanan H,
AU - Al-Omari,Awad,
AU - Al Mekhlafi,Ghaleb A,
AU - Kharaba,Ayman,
AU - Alraddadi,Basem,
AU - Almotairi,Abdullah,
AU - Al Khatib,Kasim,
AU - Abdulmomen,Ahmed,
AU - Qushmaq,Ismael,
AU - Mady,Ahmed,
AU - Solaiman,Othman,
AU - Al-Aithan,Abdulsalam M,
AU - Al-Raddadi,Rajaa,
AU - Ragab,Ahmed,
AU - Al Harthy,Abdulrahman,
AU - Al Qasim,Eman,
AU - Jose,Jesna,
AU - Al-Ghamdi,Ghassan,
AU - Merson,Laura,
AU - Fowler,Robert,
AU - Hayden,Frederick G,
AU - Arabi,Yaseen M,
Y1 - 2018/11/15/
PY - 2018/02/17/received
PY - 2018/10/19/accepted
PY - 2018/11/16/entrez
PY - 2018/11/16/pubmed
PY - 2019/4/16/medline
SP - e0206831
EP - e0206831
JF - PloS one
JO - PLoS One
VL - 13
IS - 11
N2 - BACKGROUND: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) leads to healthcare-associated transmission to patients and healthcare workers with potentially fatal outcomes. AIM: We aimed to describe the clinical course and functional outcomes of critically ill healthcare workers (HCWs) with MERS. METHODS: Data on HCWs was extracted from a multi-center retrospective cohort study on 330 critically ill patients with MERS admitted between (9/2012-9/2015). Baseline demographics, interventions and outcomes were recorded and compared between survivors and non-survivors. Survivors were approached with questionnaires to elucidate their functional outcomes using Karnofsky Performance Status Scale. FINDINGS: Thirty-Two HCWs met the inclusion criteria. Comorbidities were recorded in 34% (11/32) HCW. Death resulted in 8/32 (25%) HCWs including all 5 HCWs with chronic renal impairment at baseline. Non-surviving HCW had lower PaO2/FiO2 ratios 63.5 (57, 116.2) vs 148 (84, 194.3), p = 0.043, and received more ECMO therapy compared to survivors, 9/32 (28%) vs 4/24 (16.7%) respectively (p = 0.02).Thirteen of the surviving (13/24) HCWs responded to the questionnaire. Two HCWs confirmed functional limitations. Median number of days from hospital discharge until the questionnaires were filled was 580 (95% CI 568, 723.5) days. CONCLUSION: Approximately 10% of critically ill patients with MERS were HCWs. Hospital mortality rate was substantial (25%). Patients with chronic renal impairment represented a particularly high-risk group that should receive extra caution during suspected or confirmed MERS cases clinical care assignment and during outbreaks. Long-term repercussions of critical illness due to MERS on HCWs in particular, and patients in general, remain unknown and should be investigated in larger studies.
SN - 1932-6203
UR - https://www.unboundmedicine.com/medline/citation/30439974/Critically_ill_healthcare_workers_with_the_middle_east_respiratory_syndrome__MERS_:_A_multicenter_study_
L2 - https://dx.plos.org/10.1371/journal.pone.0206831
DB - PRIME
DP - Unbound Medicine
ER -