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Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study.
Autoimmunity 2018; 51(5):221-227A

Abstract

OBJECTIVES

This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

PATIENTS AND METHODS

Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).

RESULTS

Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018).

CONCLUSION

tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.

Authors+Show Affiliations

a Department of Women's and Children's Health , Karolinska Institutet , Stockholm , Sweden.a Department of Women's and Children's Health , Karolinska Institutet , Stockholm , Sweden. b Hepatology and Nutrition , Astrid Lindgren Children's Hospital, Karolinska University Hospital , Stockholm , Sweden.a Department of Women's and Children's Health , Karolinska Institutet , Stockholm , Sweden. c Pediatric Diabetes Clinic, Astrid Lindgren Children's Hospital , Karolinska University Hospital , Stockholm , Sweden.d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.f The Queen Silvia Children's hospital , Sahlgrenska University hospital and The Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.g Division of Pediatrics, Department of Clinical and Experimental Medicine , Linko¨ping University , Linko¨ping , Sweden.h Division of Pediatrics, Department of Clinical Science , Intervention and Technology Karolinska Institutet , Stockholm , Sweden.e Department of Pediatrics , Lund University , Lund , Sweden.d Department of clinical sciences , Lund University, Skåne University hospital , Malmö , Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30444426

Citation

Cerqueiro Bybrant, Mara, et al. "Tissue Transglutaminase Autoantibodies in Children With Newly Diagnosed Type 1 Diabetes Are Related to Human Leukocyte Antigen but Not to Islet Autoantibodies: a Swedish Nationwide Prospective Population-based Cohort Study." Autoimmunity, vol. 51, no. 5, 2018, pp. 221-227.
Cerqueiro Bybrant M, Grahnquist L, Örtqvist E, et al. Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study. Autoimmunity. 2018;51(5):221-227.
Cerqueiro Bybrant, M., Grahnquist, L., Örtqvist, E., Andersson, C., Forsander, G., Elding Larsson, H., ... Ivarsson, S. A. (2018). Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study. Autoimmunity, 51(5), pp. 221-227. doi:10.1080/08916934.2018.1494160.
Cerqueiro Bybrant M, et al. Tissue Transglutaminase Autoantibodies in Children With Newly Diagnosed Type 1 Diabetes Are Related to Human Leukocyte Antigen but Not to Islet Autoantibodies: a Swedish Nationwide Prospective Population-based Cohort Study. Autoimmunity. 2018;51(5):221-227. PubMed PMID: 30444426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies: A Swedish nationwide prospective population-based cohort study. AU - Cerqueiro Bybrant,Mara, AU - Grahnquist,Lena, AU - Örtqvist,Eva, AU - Andersson,Cecilia, AU - Forsander,Gun, AU - Elding Larsson,Helena, AU - Lernmark,Åke, AU - Ludvigsson,Johnny, AU - Marcus,Claude, AU - Carlsson,Annelie, AU - Ivarsson,Sten A, Y1 - 2018/11/16/ PY - 2018/11/18/pubmed PY - 2019/10/15/medline PY - 2018/11/17/entrez KW - Type 1 diabetes KW - celiac disease KW - human leukocyte antigen KW - islet autoantibodies KW - tissue transglutaminase antibodies SP - 221 EP - 227 JF - Autoimmunity JO - Autoimmunity VL - 51 IS - 5 N2 - OBJECTIVES: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D). PATIENTS AND METHODS: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA). RESULTS: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018). CONCLUSION: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD. SN - 1607-842X UR - https://www.unboundmedicine.com/medline/citation/30444426/Tissue_transglutaminase_autoantibodies_in_children_with_newly_diagnosed_type_1_diabetes_are_related_to_human_leukocyte_antigen_but_not_to_islet_autoantibodies:_A_Swedish_nationwide_prospective_population_based_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/08916934.2018.1494160 DB - PRIME DP - Unbound Medicine ER -