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Free insulin profiles during intensive treatment with biosynthetic human insulin.
Diabete Metab. 1988 May-Jun; 14(3):253-8.DM

Abstract

24 h profiles of free insulin and glucose were determined in insulin-dependent diabetic patients on intensive insulin regimens with biosynthetic human insulin, either as continuous subcutaneous insulin infusion (CSII) with mealtime bolus doses (n = 6), or intensified conventional insulin therapy (ICIT) with preprandial injections of regular insulin and intermediate-acting insulin at bedtime (n = 6). The free insulin profiles were similar to the normal profiles but there were some important differences: CSII gave hyperinsulinaemia at daytime compared to normal people (p less than 0.05) and also to ICIT (p less than 0.005); ICIT but not CSII gave hyperinsulinaemia at midnight (p less than 0.05) whereas fasting free insulin was too-low to keep blood glucose normal; the insulin peaks after the bolus doses were retarded with a maximum after 30-90 min and a return to the basal level after 5-7 h (ICIT) or 8-9 h (CSII). The height of the insulin peaks were of similar magnitude at all meals and did not differ significantly between ICIT, CSII, and normal people. Time-to-peak was dependent on the injection level. We conclude, that intensive regimens with biosynthetic hum insulin do not give normoinsulinaemia but insulin profiles that resemble physiology. Biosynthetic human NPH insulin may be rather short-acting for overnight glucose control. The interval that should be recommended between preprandial insulin dose and meal may vary depending on the preinjection insulin level.

Authors+Show Affiliations

Department of Internal Medicine, Regional Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3044863

Citation

Olsson, P O., et al. "Free Insulin Profiles During Intensive Treatment With Biosynthetic Human Insulin." Diabete & Metabolisme, vol. 14, no. 3, 1988, pp. 253-8.
Olsson PO, Arnqvist HJ, Von Schenck HV. Free insulin profiles during intensive treatment with biosynthetic human insulin. Diabete Metab. 1988;14(3):253-8.
Olsson, P. O., Arnqvist, H. J., & Von Schenck, H. V. (1988). Free insulin profiles during intensive treatment with biosynthetic human insulin. Diabete & Metabolisme, 14(3), 253-8.
Olsson PO, Arnqvist HJ, Von Schenck HV. Free Insulin Profiles During Intensive Treatment With Biosynthetic Human Insulin. Diabete Metab. 1988 May-Jun;14(3):253-8. PubMed PMID: 3044863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free insulin profiles during intensive treatment with biosynthetic human insulin. AU - Olsson,P O, AU - Arnqvist,H J, AU - Von Schenck,H V, PY - 1988/5/1/pubmed PY - 2000/3/11/medline PY - 1988/5/1/entrez SP - 253 EP - 8 JF - Diabete & metabolisme JO - Diabete Metab VL - 14 IS - 3 N2 - 24 h profiles of free insulin and glucose were determined in insulin-dependent diabetic patients on intensive insulin regimens with biosynthetic human insulin, either as continuous subcutaneous insulin infusion (CSII) with mealtime bolus doses (n = 6), or intensified conventional insulin therapy (ICIT) with preprandial injections of regular insulin and intermediate-acting insulin at bedtime (n = 6). The free insulin profiles were similar to the normal profiles but there were some important differences: CSII gave hyperinsulinaemia at daytime compared to normal people (p less than 0.05) and also to ICIT (p less than 0.005); ICIT but not CSII gave hyperinsulinaemia at midnight (p less than 0.05) whereas fasting free insulin was too-low to keep blood glucose normal; the insulin peaks after the bolus doses were retarded with a maximum after 30-90 min and a return to the basal level after 5-7 h (ICIT) or 8-9 h (CSII). The height of the insulin peaks were of similar magnitude at all meals and did not differ significantly between ICIT, CSII, and normal people. Time-to-peak was dependent on the injection level. We conclude, that intensive regimens with biosynthetic hum insulin do not give normoinsulinaemia but insulin profiles that resemble physiology. Biosynthetic human NPH insulin may be rather short-acting for overnight glucose control. The interval that should be recommended between preprandial insulin dose and meal may vary depending on the preinjection insulin level. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/3044863/Free_insulin_profiles_during_intensive_treatment_with_biosynthetic_human_insulin_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -