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Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) Mart.
Nat Prod Res. 2020 Feb; 34(4):494-502.NP

Abstract

A new xanthoquinodin B9 (1), together with two known xanthoquinodins, xanthoquinodin A1 (2) and xanthoquinodin A3 (3), three epipolythiodioxopiperazines, chetomin (4), chaetocochin C (5) and dethio-tetra(methylthio)chetomin (6), and four other compounds, chrysophanol (7), emodin (8), alatinone (9), and ergosterol (10) were isolated from the endophytic fungus Chaetomium globosum 7s-1, isolated from Rhapis cochinchinensis (Lour.) Mart. All isolated structures were established based on their spectroscopic data analyses. Compounds 1-6 showed antibacterial activity against Gram positive bacteria with MICs ranging from 0.02 pM to 10.81 µM. Compounds 1-6 also exhibited cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines (IC50 0.04-18.40 µM). However, they were cytotoxic towards a normal cell line (Vero cell) with IC50 values ranging from 0.04 to 3.86 µM.

Authors+Show Affiliations

Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.Center for Organic Electronic and Alternative Energy, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, Thailand.Center for Organic Electronic and Alternative Energy, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, Thailand.Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30449167

Citation

Tantapakul, Cholpisut, et al. "Bioactive Xanthoquinodins and Epipolythiodioxopiperazines From Chaetomium Globosum 7s-1, an Endophytic Fungus Isolated From Rhapis Cochinchinensis (Lour.) Mart." Natural Product Research, vol. 34, no. 4, 2020, pp. 494-502.
Tantapakul C, Promgool T, Kanokmedhakul K, et al. Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) Mart. Nat Prod Res. 2020;34(4):494-502.
Tantapakul, C., Promgool, T., Kanokmedhakul, K., Soytong, K., Song, J., Hadsadee, S., Jungsuttiwong, S., & Kanokmedhakul, S. (2020). Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) Mart. Natural Product Research, 34(4), 494-502. https://doi.org/10.1080/14786419.2018.1489392
Tantapakul C, et al. Bioactive Xanthoquinodins and Epipolythiodioxopiperazines From Chaetomium Globosum 7s-1, an Endophytic Fungus Isolated From Rhapis Cochinchinensis (Lour.) Mart. Nat Prod Res. 2020;34(4):494-502. PubMed PMID: 30449167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) Mart. AU - Tantapakul,Cholpisut, AU - Promgool,Trinop, AU - Kanokmedhakul,Kwanjai, AU - Soytong,Kasem, AU - Song,Jiaojiao, AU - Hadsadee,Sarinya, AU - Jungsuttiwong,Siriporn, AU - Kanokmedhakul,Somdej, Y1 - 2018/11/19/ PY - 2018/11/20/pubmed PY - 2020/3/11/medline PY - 2018/11/20/entrez KW - Chaetomium globosum KW - antibacterial KW - cytotoxicity KW - epipolythiodioxopiperazine KW - xanthoquinodin SP - 494 EP - 502 JF - Natural product research JO - Nat Prod Res VL - 34 IS - 4 N2 - A new xanthoquinodin B9 (1), together with two known xanthoquinodins, xanthoquinodin A1 (2) and xanthoquinodin A3 (3), three epipolythiodioxopiperazines, chetomin (4), chaetocochin C (5) and dethio-tetra(methylthio)chetomin (6), and four other compounds, chrysophanol (7), emodin (8), alatinone (9), and ergosterol (10) were isolated from the endophytic fungus Chaetomium globosum 7s-1, isolated from Rhapis cochinchinensis (Lour.) Mart. All isolated structures were established based on their spectroscopic data analyses. Compounds 1-6 showed antibacterial activity against Gram positive bacteria with MICs ranging from 0.02 pM to 10.81 µM. Compounds 1-6 also exhibited cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines (IC50 0.04-18.40 µM). However, they were cytotoxic towards a normal cell line (Vero cell) with IC50 values ranging from 0.04 to 3.86 µM. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/30449167/Bioactive_xanthoquinodins_and_epipolythiodioxopiperazines_from_Chaetomium_globosum_7s_1_an_endophytic_fungus_isolated_from_Rhapis_cochinchinensis__Lour___Mart_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1489392 DB - PRIME DP - Unbound Medicine ER -