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Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers.
Gynecol Oncol. 1988 Sep; 31(1):82-90.GO

Abstract

UGF is a mixture of human chorionic gonadotropin free beta-subunit and its fragments, and is detected in pregnancy and trophoblast disease urines. An examination of 67 nonpregnant cancer-free women showed average urine levels of 0.13 ng/ml. Six of the 67 (8.9%) had levels exceeding a selected cutoff value, 0.2 ng/ml. Of 112 woman with active gynecologic cancer, 72 (64%) had urine UGF levels exceeding this cutoff value. When urines were limited to those with creatinine greater than 0.5 mg/ml, or to first morning samples (mean creatinine 1.0 ng/ml), the sensitivity of UGF for all gynecologic cancers was raised to 76%. The sensitivity of UGF for cervical (73%), for endometrial (65%), and for ovarian (83%) cancers exceeded that of plasma CA 125 and lipid-associated sialic acid in plasma (LASA) in the same population. UGF is an exciting new tumor marker which warrants further evaluation.

Links

clones/clone libraries

Authors+Show Affiliations

Cole LA
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
Schwartz PE
No affiliation info available
Wang YX
No affiliation info available

MeSH

Antigens, NeoplasmAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanCreatineFemaleGenital Neoplasms, FemaleHumansLipidsN-Acetylneuraminic AcidPeptide FragmentsRegression AnalysisSensitivity and SpecificitySialic Acids

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3044936

Citation

Cole, L A., et al. "Urinary Gonadotropin Fragments (UGF) in Cancers of the Female Reproductive System. I. Sensitivity and Specificity, Comparison With Other Markers." Gynecologic Oncology, vol. 31, no. 1, 1988, pp. 82-90.
Cole LA, Schwartz PE, Wang YX. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecol Oncol. 1988;31(1):82-90.
Cole, L. A., Schwartz, P. E., & Wang, Y. X. (1988). Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecologic Oncology, 31(1), 82-90.
Cole LA, Schwartz PE, Wang YX. Urinary Gonadotropin Fragments (UGF) in Cancers of the Female Reproductive System. I. Sensitivity and Specificity, Comparison With Other Markers. Gynecol Oncol. 1988;31(1):82-90. PubMed PMID: 3044936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. AU - Cole,L A, AU - Schwartz,P E, AU - Wang,Y X, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 82 EP - 90 JF - Gynecologic oncology JO - Gynecol Oncol VL - 31 IS - 1 N2 - UGF is a mixture of human chorionic gonadotropin free beta-subunit and its fragments, and is detected in pregnancy and trophoblast disease urines. An examination of 67 nonpregnant cancer-free women showed average urine levels of 0.13 ng/ml. Six of the 67 (8.9%) had levels exceeding a selected cutoff value, 0.2 ng/ml. Of 112 woman with active gynecologic cancer, 72 (64%) had urine UGF levels exceeding this cutoff value. When urines were limited to those with creatinine greater than 0.5 mg/ml, or to first morning samples (mean creatinine 1.0 ng/ml), the sensitivity of UGF for all gynecologic cancers was raised to 76%. The sensitivity of UGF for cervical (73%), for endometrial (65%), and for ovarian (83%) cancers exceeded that of plasma CA 125 and lipid-associated sialic acid in plasma (LASA) in the same population. UGF is an exciting new tumor marker which warrants further evaluation. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/3044936/Urinary_gonadotropin_fragments__UGF__in_cancers_of_the_female_reproductive_system__I__Sensitivity_and_specificity_comparison_with_other_markers_ L2 - https://antibodies.cancer.gov/detail/CPTC-MUC16-1 DB - PRIME DP - Unbound Medicine ER -