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Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers.
Gynecol Oncol. 1988 Sep; 31(1):82-90.GO

Abstract

UGF is a mixture of human chorionic gonadotropin free beta-subunit and its fragments, and is detected in pregnancy and trophoblast disease urines. An examination of 67 nonpregnant cancer-free women showed average urine levels of 0.13 ng/ml. Six of the 67 (8.9%) had levels exceeding a selected cutoff value, 0.2 ng/ml. Of 112 woman with active gynecologic cancer, 72 (64%) had urine UGF levels exceeding this cutoff value. When urines were limited to those with creatinine greater than 0.5 mg/ml, or to first morning samples (mean creatinine 1.0 ng/ml), the sensitivity of UGF for all gynecologic cancers was raised to 76%. The sensitivity of UGF for cervical (73%), for endometrial (65%), and for ovarian (83%) cancers exceeded that of plasma CA 125 and lipid-associated sialic acid in plasma (LASA) in the same population. UGF is an exciting new tumor marker which warrants further evaluation.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3044936

Citation

Cole, L A., et al. "Urinary Gonadotropin Fragments (UGF) in Cancers of the Female Reproductive System. I. Sensitivity and Specificity, Comparison With Other Markers." Gynecologic Oncology, vol. 31, no. 1, 1988, pp. 82-90.
Cole LA, Schwartz PE, Wang YX. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecol Oncol. 1988;31(1):82-90.
Cole, L. A., Schwartz, P. E., & Wang, Y. X. (1988). Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecologic Oncology, 31(1), 82-90.
Cole LA, Schwartz PE, Wang YX. Urinary Gonadotropin Fragments (UGF) in Cancers of the Female Reproductive System. I. Sensitivity and Specificity, Comparison With Other Markers. Gynecol Oncol. 1988;31(1):82-90. PubMed PMID: 3044936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. AU - Cole,L A, AU - Schwartz,P E, AU - Wang,Y X, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 82 EP - 90 JF - Gynecologic oncology JO - Gynecol Oncol VL - 31 IS - 1 N2 - UGF is a mixture of human chorionic gonadotropin free beta-subunit and its fragments, and is detected in pregnancy and trophoblast disease urines. An examination of 67 nonpregnant cancer-free women showed average urine levels of 0.13 ng/ml. Six of the 67 (8.9%) had levels exceeding a selected cutoff value, 0.2 ng/ml. Of 112 woman with active gynecologic cancer, 72 (64%) had urine UGF levels exceeding this cutoff value. When urines were limited to those with creatinine greater than 0.5 mg/ml, or to first morning samples (mean creatinine 1.0 ng/ml), the sensitivity of UGF for all gynecologic cancers was raised to 76%. The sensitivity of UGF for cervical (73%), for endometrial (65%), and for ovarian (83%) cancers exceeded that of plasma CA 125 and lipid-associated sialic acid in plasma (LASA) in the same population. UGF is an exciting new tumor marker which warrants further evaluation. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/3044936/Urinary_gonadotropin_fragments__UGF__in_cancers_of_the_female_reproductive_system__I__Sensitivity_and_specificity_comparison_with_other_markers_ L2 - https://antibodies.cancer.gov/detail/CPTC-MUC16-1 DB - PRIME DP - Unbound Medicine ER -