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Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women.
Ann Epidemiol. 2019 01; 29:23-29.e1.AE

Abstract

PURPOSE

The purpose of this study was to examine the association of type II diabetes and anthropometric variables with risk of pancreatic cancer among postmenopausal women.

METHODS

Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cancer were diagnosed among 156,218 women over a median follow-up of approximately 18 years. Cox proportional hazards models were used to estimate the associations of study factors with pancreatic cancer risk.

RESULTS

Diabetes (hazards ratio (HR): 1.30; 95% confidence intervals (95% CI): 1.01-1.66), and in particular, waist circumference, waist-to-hip ratio, and waist-to-height ratio showed positive associations with pancreatic cancer risk (HRs for highest vs. lowest level 1.38; 95% CI: 1.14-1.66, 1.40; 1.17-1.68; and 1.36; 1.13-1.64, respectively). Body mass index at the baseline showed only a borderline positive association with risk (HR: 1.21; 95% CI: 0.97-1.51). Body mass index at age 50 years, but not at ages 18 and 35 years, was also associated with increased pancreatic cancer risk.

CONCLUSIONS

In this study of postmenopausal women, central adiposity and, to a lesser extent, general adiposity and a history of diabetes, were associated with increased pancreatic cancer risk.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY. Electronic address: Rhonda.arthur@einstein.yu.edu.New Rochelle, NY.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.Center for Health Innovations and Outcomes Research, Feinstein Institute for Medical Research, Northwell Health, Great Neck, NY.Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA.Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA; Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30449532

Citation

Arthur, Rhonda, et al. "Adiposity, History of Diabetes, and Risk of Pancreatic Cancer in Postmenopausal Women." Annals of Epidemiology, vol. 29, 2019, pp. 23-29.e1.
Arthur R, Kabat GC, Kim MY, et al. Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women. Ann Epidemiol. 2019;29:23-29.e1.
Arthur, R., Kabat, G. C., Kim, M. Y., Ho, G. Y. F., Chlebowski, R. T., Pan, K., & Rohan, T. E. (2019). Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women. Annals of Epidemiology, 29, 23-e1. https://doi.org/10.1016/j.annepidem.2018.09.005
Arthur R, et al. Adiposity, History of Diabetes, and Risk of Pancreatic Cancer in Postmenopausal Women. Ann Epidemiol. 2019;29:23-29.e1. PubMed PMID: 30449532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women. AU - Arthur,Rhonda, AU - Kabat,Geoffrey C, AU - Kim,Mimi Y, AU - Ho,Gloria Y F, AU - Chlebowski,Rowan T, AU - Pan,Kathy, AU - Rohan,Thomas E, Y1 - 2018/09/22/ PY - 2018/04/30/received PY - 2018/09/05/revised PY - 2018/09/12/accepted PY - 2018/11/20/pubmed PY - 2019/10/23/medline PY - 2018/11/20/entrez KW - Adiposity KW - Body mass index KW - Cohort studies KW - Diabetes KW - Pancreatic cancer KW - Postmenopausal women KW - Waist circumference KW - Waist-to-hip-ratio SP - 23 EP - 29.e1 JF - Annals of epidemiology JO - Ann Epidemiol VL - 29 N2 - PURPOSE: The purpose of this study was to examine the association of type II diabetes and anthropometric variables with risk of pancreatic cancer among postmenopausal women. METHODS: Weight, height, waist circumference, and hip circumference were measured by trained personnel, whereas history of diabetes and weight earlier in life were self-reported. Pancreatic cancer was ascertained via central review of medical records by physician adjudicators. After exclusions, 1045 cases of pancreatic cancer were diagnosed among 156,218 women over a median follow-up of approximately 18 years. Cox proportional hazards models were used to estimate the associations of study factors with pancreatic cancer risk. RESULTS: Diabetes (hazards ratio (HR): 1.30; 95% confidence intervals (95% CI): 1.01-1.66), and in particular, waist circumference, waist-to-hip ratio, and waist-to-height ratio showed positive associations with pancreatic cancer risk (HRs for highest vs. lowest level 1.38; 95% CI: 1.14-1.66, 1.40; 1.17-1.68; and 1.36; 1.13-1.64, respectively). Body mass index at the baseline showed only a borderline positive association with risk (HR: 1.21; 95% CI: 0.97-1.51). Body mass index at age 50 years, but not at ages 18 and 35 years, was also associated with increased pancreatic cancer risk. CONCLUSIONS: In this study of postmenopausal women, central adiposity and, to a lesser extent, general adiposity and a history of diabetes, were associated with increased pancreatic cancer risk. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/30449532/Adiposity_history_of_diabetes_and_risk_of_pancreatic_cancer_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(18)30320-X DB - PRIME DP - Unbound Medicine ER -