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Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: A Prospective Cohort Study.
Front Neurol 2018; 9:874FN

Abstract

Objective:

To explore the association between combined lifestyle risk factors with quality of life in people with multiple sclerosis (MS) over 2.5 years.

Methods:

People with MS were recruited to participate in a comprehensive online survey regarding their demographic and clinical characteristics, health-related quality of life (HRQOL), and lifestyle behaviors including physical activity, alcohol consumption, cigarette smoking, body mass index, and dietary habits measured at baseline and 2.5-year follow-up. A combined healthy lifestyle index score (HLIS) was constructed by assigning scores of 0-4 to each of the lifestyle risk factors, for which higher values indicate healthier lifestyle behavior. Multivariable linear regression modeling was used to assess whether the HLIS at baseline was associated with the physical and mental HRQOL over the study period in this sample of people with MS.

Results:

Of 2,466 participants with confirmed MS, 1,401 (57%) completed the follow-up. Multivariable linear regression analyses demonstrated that every 5-point increase (of a possible total of 20) in the baseline HLIS was associated with 1.7 (95% CI: 0.2-3.2) and 2.5 (95% CI: 1.0-4.0) higher scores in the change in physical and mental HRQOL components from baseline to follow-up respectively.

Conclusion:

Findings suggest the importance of healthy lifestyle behavior in quality of life in MS. A healthy lifestyle program focusing on these behaviors has the potential to positively influence health-related quality of life for people with MS.

Authors+Show Affiliations

Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Biostatistics Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. Biostatistics Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30450074

Citation

Leong, Teng I., et al. "Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: a Prospective Cohort Study." Frontiers in Neurology, vol. 9, 2018, p. 874.
Leong TI, Weiland TJ, Jelinek GA, et al. Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: A Prospective Cohort Study. Front Neurol. 2018;9:874.
Leong, T. I., Weiland, T. J., Jelinek, G. A., Simpson, S., Brown, C. R., Neate, S. L., ... De Livera, A. M. (2018). Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: A Prospective Cohort Study. Frontiers in Neurology, 9, p. 874. doi:10.3389/fneur.2018.00874.
Leong TI, et al. Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: a Prospective Cohort Study. Front Neurol. 2018;9:874. PubMed PMID: 30450074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal Associations of the Healthy Lifestyle Index Score With Quality of Life in People With Multiple Sclerosis: A Prospective Cohort Study. AU - Leong,Teng I, AU - Weiland,Tracey J, AU - Jelinek,George A, AU - Simpson,Steve, AU - Brown,Chelsea R, AU - Neate,Sandra L, AU - Taylor,Keryn L, AU - O'Kearney,Emily, AU - Milanzi,Elasma, AU - De Livera,Alysha M, Y1 - 2018/11/02/ PY - 2018/01/05/received PY - 2018/09/27/accepted PY - 2018/11/20/entrez PY - 2018/11/20/pubmed PY - 2018/11/20/medline KW - QOL KW - health outcomes KW - lifestyle KW - multiple sclerosis KW - quality of life KW - risk factors SP - 874 EP - 874 JF - Frontiers in neurology JO - Front Neurol VL - 9 N2 - Objective: To explore the association between combined lifestyle risk factors with quality of life in people with multiple sclerosis (MS) over 2.5 years. Methods: People with MS were recruited to participate in a comprehensive online survey regarding their demographic and clinical characteristics, health-related quality of life (HRQOL), and lifestyle behaviors including physical activity, alcohol consumption, cigarette smoking, body mass index, and dietary habits measured at baseline and 2.5-year follow-up. A combined healthy lifestyle index score (HLIS) was constructed by assigning scores of 0-4 to each of the lifestyle risk factors, for which higher values indicate healthier lifestyle behavior. Multivariable linear regression modeling was used to assess whether the HLIS at baseline was associated with the physical and mental HRQOL over the study period in this sample of people with MS. Results: Of 2,466 participants with confirmed MS, 1,401 (57%) completed the follow-up. Multivariable linear regression analyses demonstrated that every 5-point increase (of a possible total of 20) in the baseline HLIS was associated with 1.7 (95% CI: 0.2-3.2) and 2.5 (95% CI: 1.0-4.0) higher scores in the change in physical and mental HRQOL components from baseline to follow-up respectively. Conclusion: Findings suggest the importance of healthy lifestyle behavior in quality of life in MS. A healthy lifestyle program focusing on these behaviors has the potential to positively influence health-related quality of life for people with MS. SN - 1664-2295 UR - https://www.unboundmedicine.com/medline/citation/30450074/Longitudinal_Associations_of_the_Healthy_Lifestyle_Index_Score_With_Quality_of_Life_in_People_With_Multiple_Sclerosis:_A_Prospective_Cohort_Study_ L2 - https://doi.org/10.3389/fneur.2018.00874 DB - PRIME DP - Unbound Medicine ER -