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Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C) in prediction of metabolic syndrome in Polish obese children and adolescents.
Acta Biochim Pol. 2018 11 19; 65(4):605-611.AB

Abstract

The triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) is a useful surrogate marker of insulin resistance and cardiovascular risk factors. We aimed to assess the relationship between the TG/HDL-C ratio and insulin resistance (IR) and its usefulness in prediction of the metabolic syndrome (MS). This retrospective study involved 122 obese children with the mean age of 11.6±3 years and their 58 healthy lean peers. Anthropometric measurements, blood pressure, the plasma lipid profile and oral glucose tolerance test (OGTT) were analyzed. Based on the obtained results, the TG/HDL-C ratio and surrogate insulin resistance indices (HOMA-IR, FGIR, QUICKI, OGIS, Matsuda index) were calculated. The TG/HDL-C ratio positively correlated with weight, waist circumference, waist to hip ratio (WHR), lipid profile, HOMA-IR, fasting insulin and insulin measurements during OGTT, and negatively correlated with FGIR, QUICKI, OGIS, and the Matsuda index. Obese children with the TG/HDL-C ratio≥3 (47.5%) had higher values of WHR and HOMA-IR, and lower ones of FGIR, QUICKI, OGIS, and the Matsuda index when compared to their obese peers with the TG/HDL-C<3. The area under the curve (AUC) calculated for each insulin resistance index in prediction of the metabolic syndrome was the largest for the TG/HDL-C ratio (0.8936, 95% Cl:0.809-0.977, p=0.000). For 1 unit increase in the TG/HDL-C ratio, the odds for having MS increased by 2.09 times. The TG/HDL-C ratio is a good surrogate marker of insulin resistance in obese children. When comparing the usefulness of some IR markers in prediction of the metabolic syndrome, the TG/HDL-C ratio seems to be the best one and should be used in clinical practice to identify children at risk of metabolic syndrome development.

Authors+Show Affiliations

Department of Paediatric and Endocrinology, Medical Univesity of Warsaw, Warszawa, Poland.Department of Paediatric and Endocrinology, Medical Univesity of Warsaw, Warszawa, Poland.Department of Paediatric and Endocrinology, Medical Univesity of Warsaw, Warszawa, Poland.Department of Paediatric and Endocrinology, Medical Univesity of Warsaw, Warszawa, Poland.Department of Paediatric and Endocrinology, Medical Univesity of Warsaw, Warszawa, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30451245

Citation

Krawczyk, Monika, et al. "Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) in Prediction of Metabolic Syndrome in Polish Obese Children and Adolescents." Acta Biochimica Polonica, vol. 65, no. 4, 2018, pp. 605-611.
Krawczyk M, Rumińska M, Witkowska-Sędek E, et al. Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C) in prediction of metabolic syndrome in Polish obese children and adolescents. Acta Biochim Pol. 2018;65(4):605-611.
Krawczyk, M., Rumińska, M., Witkowska-Sędek, E., Majcher, A., & Pyrżak, B. (2018). Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C) in prediction of metabolic syndrome in Polish obese children and adolescents. Acta Biochimica Polonica, 65(4), 605-611. https://doi.org/10.18388/abp.2018_2649
Krawczyk M, et al. Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio (TG/HDL-C) in Prediction of Metabolic Syndrome in Polish Obese Children and Adolescents. Acta Biochim Pol. 2018 11 19;65(4):605-611. PubMed PMID: 30451245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of the Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C) in prediction of metabolic syndrome in Polish obese children and adolescents. AU - Krawczyk,Monika, AU - Rumińska,Małgorzata, AU - Witkowska-Sędek,Ewelina, AU - Majcher,Anna, AU - Pyrżak,Beata, PY - 2018/07/23/received PY - 2018/10/16/accepted PY - 2018/11/20/pubmed PY - 2019/3/26/medline PY - 2018/11/20/entrez SP - 605 EP - 611 JF - Acta biochimica Polonica JO - Acta Biochim. Pol. VL - 65 IS - 4 N2 - The triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) is a useful surrogate marker of insulin resistance and cardiovascular risk factors. We aimed to assess the relationship between the TG/HDL-C ratio and insulin resistance (IR) and its usefulness in prediction of the metabolic syndrome (MS). This retrospective study involved 122 obese children with the mean age of 11.6±3 years and their 58 healthy lean peers. Anthropometric measurements, blood pressure, the plasma lipid profile and oral glucose tolerance test (OGTT) were analyzed. Based on the obtained results, the TG/HDL-C ratio and surrogate insulin resistance indices (HOMA-IR, FGIR, QUICKI, OGIS, Matsuda index) were calculated. The TG/HDL-C ratio positively correlated with weight, waist circumference, waist to hip ratio (WHR), lipid profile, HOMA-IR, fasting insulin and insulin measurements during OGTT, and negatively correlated with FGIR, QUICKI, OGIS, and the Matsuda index. Obese children with the TG/HDL-C ratio≥3 (47.5%) had higher values of WHR and HOMA-IR, and lower ones of FGIR, QUICKI, OGIS, and the Matsuda index when compared to their obese peers with the TG/HDL-C<3. The area under the curve (AUC) calculated for each insulin resistance index in prediction of the metabolic syndrome was the largest for the TG/HDL-C ratio (0.8936, 95% Cl:0.809-0.977, p=0.000). For 1 unit increase in the TG/HDL-C ratio, the odds for having MS increased by 2.09 times. The TG/HDL-C ratio is a good surrogate marker of insulin resistance in obese children. When comparing the usefulness of some IR markers in prediction of the metabolic syndrome, the TG/HDL-C ratio seems to be the best one and should be used in clinical practice to identify children at risk of metabolic syndrome development. SN - 1734-154X UR - https://www.unboundmedicine.com/medline/citation/30451245/Usefulness_of_the_Triglycerides_to_High_Density_Lipoprotein_Cholesterol_ratio__TG/HDL_C__in_prediction_of_metabolic_syndrome_in_Polish_obese_children_and_adolescents_ L2 - http://www.diseaseinfosearch.org/result/1010 DB - PRIME DP - Unbound Medicine ER -