Abstract
Excessive alcohol consumption can lead to a spectrum of liver histopathology, including steatosis, steatohepatitis, foamy degeneration, fatty liver with cholestasis, and cirrhosis. Although variability in sampling and pathologist interpretation are of some concern, liver biopsy remains the gold standard for distinguishing between steatohepatitis and noninflammatory histologic patterns of injury that can also cause the clinical syndrome of alcohol-related hepatitis. Liver biopsy is not routinely recommended to ascertain a diagnosis of alcohol-related liver disease in patients with an uncertain alcohol history, because the histologic features of alcohol-related liver diseases can be found in other diseases, including nonalcoholic steatohepatitis and drug-induced liver injury.
TY - JOUR
T1 - Histopathology of Alcohol-Related Liver Diseases.
AU - Roth,Nitzan C,
AU - Qin,Jia,
PY - 2018/11/21/entrez
PY - 2018/11/21/pubmed
PY - 2019/9/17/medline
KW - Alcohol-related liver disease
KW - Alcoholic fatty liver with cholestasis
KW - Alcoholic foamy degeneration
KW - Alcoholic hepatitis
KW - Alcoholic steatohepatitis
KW - Histology
KW - Liver biopsy
SP - 11
EP - 23
JF - Clinics in liver disease
JO - Clin Liver Dis
VL - 23
IS - 1
N2 - Excessive alcohol consumption can lead to a spectrum of liver histopathology, including steatosis, steatohepatitis, foamy degeneration, fatty liver with cholestasis, and cirrhosis. Although variability in sampling and pathologist interpretation are of some concern, liver biopsy remains the gold standard for distinguishing between steatohepatitis and noninflammatory histologic patterns of injury that can also cause the clinical syndrome of alcohol-related hepatitis. Liver biopsy is not routinely recommended to ascertain a diagnosis of alcohol-related liver disease in patients with an uncertain alcohol history, because the histologic features of alcohol-related liver diseases can be found in other diseases, including nonalcoholic steatohepatitis and drug-induced liver injury.
SN - 1557-8224
UR - https://www.unboundmedicine.com/medline/citation/30454825/Histopathology_of_Alcohol_Related_Liver_Diseases_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-3261(18)30077-1
DB - PRIME
DP - Unbound Medicine
ER -