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Histopathology of Alcohol-Related Liver Diseases.
Clin Liver Dis. 2019 02; 23(1):11-23.CL

Abstract

Excessive alcohol consumption can lead to a spectrum of liver histopathology, including steatosis, steatohepatitis, foamy degeneration, fatty liver with cholestasis, and cirrhosis. Although variability in sampling and pathologist interpretation are of some concern, liver biopsy remains the gold standard for distinguishing between steatohepatitis and noninflammatory histologic patterns of injury that can also cause the clinical syndrome of alcohol-related hepatitis. Liver biopsy is not routinely recommended to ascertain a diagnosis of alcohol-related liver disease in patients with an uncertain alcohol history, because the histologic features of alcohol-related liver diseases can be found in other diseases, including nonalcoholic steatohepatitis and drug-induced liver injury.

Authors+Show Affiliations

Sandra Atlas Bass Center for Liver Diseases Department of Medicine Northwell Health, 400 Community Drive, Manhasset, NY 11030, USA. Electronic address: NRoth2@northwell.edu.Department of Pathology, The Department of Veteran Affairs New York Harbor Healthcare System, 800 Poly Place, Brooklyn, NY 11209, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30454825

Citation

Roth, Nitzan C., and Jia Qin. "Histopathology of Alcohol-Related Liver Diseases." Clinics in Liver Disease, vol. 23, no. 1, 2019, pp. 11-23.
Roth NC, Qin J. Histopathology of Alcohol-Related Liver Diseases. Clin Liver Dis. 2019;23(1):11-23.
Roth, N. C., & Qin, J. (2019). Histopathology of Alcohol-Related Liver Diseases. Clinics in Liver Disease, 23(1), 11-23. https://doi.org/10.1016/j.cld.2018.09.001
Roth NC, Qin J. Histopathology of Alcohol-Related Liver Diseases. Clin Liver Dis. 2019;23(1):11-23. PubMed PMID: 30454825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathology of Alcohol-Related Liver Diseases. AU - Roth,Nitzan C, AU - Qin,Jia, PY - 2018/11/21/entrez PY - 2018/11/21/pubmed PY - 2019/9/17/medline KW - Alcohol-related liver disease KW - Alcoholic fatty liver with cholestasis KW - Alcoholic foamy degeneration KW - Alcoholic hepatitis KW - Alcoholic steatohepatitis KW - Histology KW - Liver biopsy SP - 11 EP - 23 JF - Clinics in liver disease JO - Clin Liver Dis VL - 23 IS - 1 N2 - Excessive alcohol consumption can lead to a spectrum of liver histopathology, including steatosis, steatohepatitis, foamy degeneration, fatty liver with cholestasis, and cirrhosis. Although variability in sampling and pathologist interpretation are of some concern, liver biopsy remains the gold standard for distinguishing between steatohepatitis and noninflammatory histologic patterns of injury that can also cause the clinical syndrome of alcohol-related hepatitis. Liver biopsy is not routinely recommended to ascertain a diagnosis of alcohol-related liver disease in patients with an uncertain alcohol history, because the histologic features of alcohol-related liver diseases can be found in other diseases, including nonalcoholic steatohepatitis and drug-induced liver injury. SN - 1557-8224 UR - https://www.unboundmedicine.com/medline/citation/30454825/Histopathology_of_Alcohol_Related_Liver_Diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-3261(18)30077-1 DB - PRIME DP - Unbound Medicine ER -