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Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide.
Adv Biol Regul 2018; 70:40-50AB

Abstract

Sphingolipids are class of metabolically distinct lipids that play structural and signaling functions in all organisms. Sphingolipid metabolism is deregulated during various diseases such as cancer, neurological and immune disorders, and metabolic syndrome. With the advancement of sphingo-lipidomics and sphingo-genomics, an understanding of the specific roles of ceramide, the quintessential bioactive sphingolipid, in fatty liver disease has taken shape. Two major pathways for ceramide generation, the de novo pathway and the sphingomyelinase pathway are activated in the course of both, the non-alcoholic and the alcoholic, forms of fatty liver disease. The mechanisms of activation of these two pathways are distinct and reflect the different disease etiology in each case; at the same time, common processes impacted by the resulting ceramide overproduction involve lipotoxocity, ER/mitochondrial stress, inflammation, and de-regulation of hepatic lipid metabolism. Studies in human patients and animal models have delineated specific enzymes and ceramide species that are involved at the different stages of the disease, and represent novel pharmaceutical targets for successful management of fatty liver disease.

Authors+Show Affiliations

Department of Physiology, University of Kentucky College of Medicine, 800 Rose Str., MS 508, Lexington, KY, 40536, United States. Electronic address: mariana.karakashian@uky.edu.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

30455063

Citation

Nikolova-Karakashian, Mariana. "Alcoholic and Non-alcoholic Fatty Liver Disease: Focus On Ceramide." Advances in Biological Regulation, vol. 70, 2018, pp. 40-50.
Nikolova-Karakashian M. Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide. Adv Biol Regul. 2018;70:40-50.
Nikolova-Karakashian, M. (2018). Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide. Advances in Biological Regulation, 70, pp. 40-50. doi:10.1016/j.jbior.2018.11.004.
Nikolova-Karakashian M. Alcoholic and Non-alcoholic Fatty Liver Disease: Focus On Ceramide. Adv Biol Regul. 2018;70:40-50. PubMed PMID: 30455063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcoholic and non-alcoholic fatty liver disease: Focus on ceramide. A1 - Nikolova-Karakashian,Mariana, Y1 - 2018/11/14/ PY - 2018/09/07/received PY - 2018/11/13/revised PY - 2018/11/13/accepted PY - 2018/11/21/pubmed PY - 2018/11/21/medline PY - 2018/11/21/entrez SP - 40 EP - 50 JF - Advances in biological regulation JO - Adv Biol Regul VL - 70 N2 - Sphingolipids are class of metabolically distinct lipids that play structural and signaling functions in all organisms. Sphingolipid metabolism is deregulated during various diseases such as cancer, neurological and immune disorders, and metabolic syndrome. With the advancement of sphingo-lipidomics and sphingo-genomics, an understanding of the specific roles of ceramide, the quintessential bioactive sphingolipid, in fatty liver disease has taken shape. Two major pathways for ceramide generation, the de novo pathway and the sphingomyelinase pathway are activated in the course of both, the non-alcoholic and the alcoholic, forms of fatty liver disease. The mechanisms of activation of these two pathways are distinct and reflect the different disease etiology in each case; at the same time, common processes impacted by the resulting ceramide overproduction involve lipotoxocity, ER/mitochondrial stress, inflammation, and de-regulation of hepatic lipid metabolism. Studies in human patients and animal models have delineated specific enzymes and ceramide species that are involved at the different stages of the disease, and represent novel pharmaceutical targets for successful management of fatty liver disease. SN - 2212-4934 UR - https://www.unboundmedicine.com/medline/citation/30455063/Alcoholic_and_non-alcoholic_fatty_liver_disease:_Focus_on_ceramide L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4926(18)30144-1 DB - PRIME DP - Unbound Medicine ER -