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Meta-analysis of upgrade rates in 3163 radial scars excised after needle core biopsy diagnosis.
Breast Cancer Res Treat. 2019 Feb; 174(1):165-177.BC

Abstract

BACKGROUND

Since concurrent malignancy may be associated with radial scars (RS) in up to 45% of RS diagnosed on core biopsy, surgical excision is usually advised. Recent very low upgrade rates have caused a re-evaluation of the need for routine surgery. We aimed to find subsets of RS at such low risk of upgrade, as to render imaging surveillance a plausible alternative to surgery.

DESIGN

We performed a systematic review of the Pubmed, Cochrane and Embase databases, focusing on the following eligibility criteria: full papers, published after 1998, in English, included at least 5 RS, provided information on needle biopsy gauge and upgrade rates based on the excised lesion. For the meta-analysis, studies were grouped by the presence of histologic atypia and the core needle gauge. Study-specific and pooled upgrade rates were calculated for each subgroup.

RESULTS

49 studies that included 3163 RS with surgical outcomes are included. There were 217 upgrades to malignancies, 71 (32.7%) invasive and 144 (66.4%) DCIS. The random-effects pooled estimate was 7% (95% CI 5, 9%). Among the pre-planned subgroups, in RS assessed by 14G NCB the upgrade rates were: without atypia - 5% (95% CI 3, 8%), mixed or presence of atypia not specified - 15% (95% CI 10, 20%), with atypia - 29% (95% CI 20, 38%). For RS assessed by a mix of 8-16G cores the respective upgrade rates were 2% (95% CI 1, 4%), 12% (95% CI 6, 18%) and 11% (95% CI 3, 23%) and for RS assessed by 8-11 vacuum assisted biopsies 1% (95% CI 0, 4%), 5% (95% CI 0, 11%) and 18% for the one study of RS with atypia assessed by VAB. Surgery after VAB excision showed no upgrades. The difference across all subgroups was statistically significant.

CONCLUSION

When stratified by atypia and biopsy gauge, upgrade rates in RS are consistent and predictable. RS assessed by VABs and lacking atypia have a 1% (95% CI 0, 4%) upgrade rate to DCIS. Other groups have upgrade rates of 2-28%. This risk may be reduced by VAB excision. The results of this meta-analysis provide a decision aid and evidence-based selection criteria for surgery after a needle biopsy diagnosis of RS.

Authors+Show Affiliations

South Australian Pathology, Royal Adelaide Hospital, Adelaide, SA, Australia. gelareh.farshid2@sa.gov.au. BreastScreen South Australia, Flinders Street, Adelaide, SA, Australia. gelareh.farshid2@sa.gov.au. Discipline of Medicine, Adelaide University, North Terrace, Adelaide, SA, Australia. gelareh.farshid2@sa.gov.au.Cancer Epidemiology and Population Health Research Group, University of South Australia, Adelaide, Australia.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30460464

Citation

Farshid, Gelareh, and Elizabeth Buckley. "Meta-analysis of Upgrade Rates in 3163 Radial Scars Excised After Needle Core Biopsy Diagnosis." Breast Cancer Research and Treatment, vol. 174, no. 1, 2019, pp. 165-177.
Farshid G, Buckley E. Meta-analysis of upgrade rates in 3163 radial scars excised after needle core biopsy diagnosis. Breast Cancer Res Treat. 2019;174(1):165-177.
Farshid, G., & Buckley, E. (2019). Meta-analysis of upgrade rates in 3163 radial scars excised after needle core biopsy diagnosis. Breast Cancer Research and Treatment, 174(1), 165-177. https://doi.org/10.1007/s10549-018-5040-3
Farshid G, Buckley E. Meta-analysis of Upgrade Rates in 3163 Radial Scars Excised After Needle Core Biopsy Diagnosis. Breast Cancer Res Treat. 2019;174(1):165-177. PubMed PMID: 30460464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of upgrade rates in 3163 radial scars excised after needle core biopsy diagnosis. AU - Farshid,Gelareh, AU - Buckley,Elizabeth, Y1 - 2018/11/20/ PY - 2018/07/20/received PY - 2018/11/02/accepted PY - 2018/11/22/pubmed PY - 2019/7/10/medline PY - 2018/11/22/entrez KW - Breast cancer KW - Core biopsy KW - Mammography KW - Radial scar KW - Screening SP - 165 EP - 177 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 174 IS - 1 N2 - BACKGROUND: Since concurrent malignancy may be associated with radial scars (RS) in up to 45% of RS diagnosed on core biopsy, surgical excision is usually advised. Recent very low upgrade rates have caused a re-evaluation of the need for routine surgery. We aimed to find subsets of RS at such low risk of upgrade, as to render imaging surveillance a plausible alternative to surgery. DESIGN: We performed a systematic review of the Pubmed, Cochrane and Embase databases, focusing on the following eligibility criteria: full papers, published after 1998, in English, included at least 5 RS, provided information on needle biopsy gauge and upgrade rates based on the excised lesion. For the meta-analysis, studies were grouped by the presence of histologic atypia and the core needle gauge. Study-specific and pooled upgrade rates were calculated for each subgroup. RESULTS: 49 studies that included 3163 RS with surgical outcomes are included. There were 217 upgrades to malignancies, 71 (32.7%) invasive and 144 (66.4%) DCIS. The random-effects pooled estimate was 7% (95% CI 5, 9%). Among the pre-planned subgroups, in RS assessed by 14G NCB the upgrade rates were: without atypia - 5% (95% CI 3, 8%), mixed or presence of atypia not specified - 15% (95% CI 10, 20%), with atypia - 29% (95% CI 20, 38%). For RS assessed by a mix of 8-16G cores the respective upgrade rates were 2% (95% CI 1, 4%), 12% (95% CI 6, 18%) and 11% (95% CI 3, 23%) and for RS assessed by 8-11 vacuum assisted biopsies 1% (95% CI 0, 4%), 5% (95% CI 0, 11%) and 18% for the one study of RS with atypia assessed by VAB. Surgery after VAB excision showed no upgrades. The difference across all subgroups was statistically significant. CONCLUSION: When stratified by atypia and biopsy gauge, upgrade rates in RS are consistent and predictable. RS assessed by VABs and lacking atypia have a 1% (95% CI 0, 4%) upgrade rate to DCIS. Other groups have upgrade rates of 2-28%. This risk may be reduced by VAB excision. The results of this meta-analysis provide a decision aid and evidence-based selection criteria for surgery after a needle biopsy diagnosis of RS. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/30460464/Meta_analysis_of_upgrade_rates_in_3163_radial_scars_excised_after_needle_core_biopsy_diagnosis_ DB - PRIME DP - Unbound Medicine ER -