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Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis.
Arch Gynecol Obstet 2019; 299(1):35-46AG

Abstract

PURPOSE

The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer).

METHODS

We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR).

RESULTS

Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case-control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)].

CONCLUSIONS

Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.

Authors+Show Affiliations

Weifang Medical University, Weifang, China.Weifang Traditional Chinese Hospital, Weifang, China.Weifang Traditional Chinese Hospital, Weifang, China.Weifang Traditional Chinese Hospital, Weifang, China.Shandong University of Traditional Chinese Medicine, Jinan, China.Shandong University of Traditional Chinese Medicine, Jinan, China.Weifang Medical University, Weifang, China.Shandong University of Traditional Chinese Medicine, Jinan, China.Weifang Medical University, Weifang, China.Qingdao University, Qingdao, China.Department of Oncology, Weifang Medical College Affiliated Hospital, No. 465, Yuhe Road, Kuiwen District, Weifang, ShanDong, China. scgdoctor@126.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30460611

Citation

Li, Jia, et al. "Impact of Endometriosis On Risk of Ovarian, Endometrial and Cervical Cancers: a Meta-analysis." Archives of Gynecology and Obstetrics, vol. 299, no. 1, 2019, pp. 35-46.
Li J, Liu R, Tang S, et al. Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. Arch Gynecol Obstet. 2019;299(1):35-46.
Li, J., Liu, R., Tang, S., Feng, F., Liu, C., Wang, L., ... Sun, C. (2019). Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. Archives of Gynecology and Obstetrics, 299(1), pp. 35-46. doi:10.1007/s00404-018-4968-1.
Li J, et al. Impact of Endometriosis On Risk of Ovarian, Endometrial and Cervical Cancers: a Meta-analysis. Arch Gynecol Obstet. 2019;299(1):35-46. PubMed PMID: 30460611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. AU - Li,Jia, AU - Liu,Ruijuan, AU - Tang,Shifeng, AU - Feng,Fubin, AU - Liu,Cun, AU - Wang,Lu, AU - Zhao,Wenge, AU - Zhang,Tingting, AU - Yao,Yan, AU - Wang,Xue, AU - Sun,Changgang, Y1 - 2018/11/20/ PY - 2018/04/20/received PY - 2018/11/11/accepted PY - 2018/11/22/pubmed PY - 2020/1/10/medline PY - 2018/11/22/entrez KW - Cervical cancer KW - Endometrial cancer KW - Endometriosis KW - Gynecological cancer KW - Ovarian cancer KW - Risk SP - 35 EP - 46 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 299 IS - 1 N2 - PURPOSE: The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer). METHODS: We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR). RESULTS: Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case-control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)]. CONCLUSIONS: Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/30460611/Impact_of_endometriosis_on_risk_of_ovarian_endometrial_and_cervical_cancers:_a_meta_analysis_ L2 - https://dx.doi.org/10.1007/s00404-018-4968-1 DB - PRIME DP - Unbound Medicine ER -