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Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee.
Int J Rheum Dis. 2019 Mar; 22(3):392-398.IJ

Abstract

AIM

To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD).

METHODS

A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical assessments with a follow-up period of 24 months after the first cycle. The primary efficacy measure was the visual analogue scale (VAS) pain score. The second efficacy measure included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and the patients' and physicians' global assessments. Tolerability was evaluated based on adverse events (AEs).

RESULTS

Seventy-one patients (83.5%) completed the final study. The VAS was significantly reduced from 65.06 ± 12.21 mm (mean ± standard deviation [SD]) at baseline to 30.17 ± 11.92 mm at 6 months and was maintained for 24 months (35.79 ± 7.92 mm, P < 0.01 vs baseline). This finding was supported by the secondary variables (the WOMAC A, B and C scores; the total WOMAC scores; and the global assessments of the patients and their physicians at months 6, 12, 18 and 24). The overall incidence of AEs during the first and second cycles was 8 (9.4%) and 7 patients (8.2%), respectively. No serious AEs were reported.

CONCLUSIONS

Repeated once yearly cycles of intra-articular sodium hyaluronate injections may improve knee KBD symptoms during the inbetween cycle period as well as exert a significant carry-over effect for at least 1 year after the repeated cycle. Other randomized double-blind studies are needed to confirm the findings from our study.

Authors+Show Affiliations

Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.Orthopedic Department, West China Hospital, Sichuan University, Chengdu, China.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

30460780

Citation

Tang, Xin, et al. "Long-term Efficacy of Repeated Sodium Hyaluronate Injections in Adult Patients With Kashin-Beck Disease of the Knee." International Journal of Rheumatic Diseases, vol. 22, no. 3, 2019, pp. 392-398.
Tang X, Zhou ZK, Shen B, et al. Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. Int J Rheum Dis. 2019;22(3):392-398.
Tang, X., Zhou, Z. K., Shen, B., Kang, P. D., Pei, F. X., & Li, J. (2019). Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. International Journal of Rheumatic Diseases, 22(3), 392-398. https://doi.org/10.1111/1756-185X.13435
Tang X, et al. Long-term Efficacy of Repeated Sodium Hyaluronate Injections in Adult Patients With Kashin-Beck Disease of the Knee. Int J Rheum Dis. 2019;22(3):392-398. PubMed PMID: 30460780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. AU - Tang,Xin, AU - Zhou,Zong-Ke, AU - Shen,Bin, AU - Kang,Peng-de, AU - Pei,Fu-Xing, AU - Li,Jian, Y1 - 2018/11/20/ PY - 2016/12/01/received PY - 2017/05/09/revised PY - 2018/09/28/accepted PY - 2018/11/22/pubmed PY - 2019/7/30/medline PY - 2018/11/22/entrez KW - Kashin-Beck KW - disease knee KW - efficacy KW - sodium hyaluronate SP - 392 EP - 398 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 22 IS - 3 N2 - AIM: To prospectively evaluate the long-term efficacy and safety of repeated sodium hyaluronate injections for the treatment of knee pain due to Kashin-Beck disease (KBD). METHODS: A total of 85 patients with KBD-based knee pain were treated with two cycles of a 5-week course of sodium hyaluronate and received clinical assessments with a follow-up period of 24 months after the first cycle. The primary efficacy measure was the visual analogue scale (VAS) pain score. The second efficacy measure included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores; and the patients' and physicians' global assessments. Tolerability was evaluated based on adverse events (AEs). RESULTS: Seventy-one patients (83.5%) completed the final study. The VAS was significantly reduced from 65.06 ± 12.21 mm (mean ± standard deviation [SD]) at baseline to 30.17 ± 11.92 mm at 6 months and was maintained for 24 months (35.79 ± 7.92 mm, P < 0.01 vs baseline). This finding was supported by the secondary variables (the WOMAC A, B and C scores; the total WOMAC scores; and the global assessments of the patients and their physicians at months 6, 12, 18 and 24). The overall incidence of AEs during the first and second cycles was 8 (9.4%) and 7 patients (8.2%), respectively. No serious AEs were reported. CONCLUSIONS: Repeated once yearly cycles of intra-articular sodium hyaluronate injections may improve knee KBD symptoms during the inbetween cycle period as well as exert a significant carry-over effect for at least 1 year after the repeated cycle. Other randomized double-blind studies are needed to confirm the findings from our study. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/30460780/Long_term_efficacy_of_repeated_sodium_hyaluronate_injections_in_adult_patients_with_Kashin_Beck_disease_of_the_knee_ L2 - https://doi.org/10.1111/1756-185X.13435 DB - PRIME DP - Unbound Medicine ER -