Tags

Type your tag names separated by a space and hit enter

Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study.
Eur J Epidemiol. 2019 Jan; 34(1):57-66.EJ

Abstract

Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56,435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on the allele score were performed to assess the presence of causal associations of serum 25(OH)D with the lipids. To quantify the causal effects, the inverse-variance weighted method was used for calculating MR estimates based on summarized data of individual single-nucleotide polymorphisms. The MR estimate with 95% confidence interval (CI) represents percentage difference in the lipid level per genetically determined 25 nmol/L increase in 25(OH)D. The 25(OH)D allele score demonstrated a clear association with high-density lipoprotein (HDL) cholesterol (p = 0.007) but no association with total or non-HDL cholesterol or triglycerides (p ≥ 0.27). The MR estimate showed 2.52% (95% CI 0.79-4.25%) increase in HDL cholesterol per genetically determined 25 nmol/L increase in 25(OH)D, which was stronger than the corresponding estimate of 1.83% (95% CI 0.85-2.81%) from the observational analysis. The MR estimates for total cholesterol (0.60%, 95% CI - 0.73 to 1.94%), non-HDL cholesterol (0.04%, 95% CI - 1.79 to 1.88%) and triglycerides (- 2.74%, 95% CI - 6.16 to 0.67%) showed no associations. MR analysis of data from a population-based cohort suggested a causal and positive association between serum 25(OH)D and HDL cholesterol.

Authors+Show Affiliations

Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.Department of Clinical and Molecular Medicine (IKOM), NTNU - Norwegian University of Science and Technology, Trondheim, Norway. Department of Immunology and Transfusion Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.Department of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK.School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.Department of Clinical and Molecular Medicine (IKOM), NTNU - Norwegian University of Science and Technology, Trondheim, Norway. yi-qian.sun@ntnu.no.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30465296

Citation

Mai, Xiao-Mei, et al. "Potential Causal Associations of Serum 25-hydroxyvitamin D With Lipids: a Mendelian Randomization Approach of the HUNT Study." European Journal of Epidemiology, vol. 34, no. 1, 2019, pp. 57-66.
Mai XM, Videm V, Sheehan NA, et al. Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study. Eur J Epidemiol. 2019;34(1):57-66.
Mai, X. M., Videm, V., Sheehan, N. A., Chen, Y., Langhammer, A., & Sun, Y. Q. (2019). Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study. European Journal of Epidemiology, 34(1), 57-66. https://doi.org/10.1007/s10654-018-0465-x
Mai XM, et al. Potential Causal Associations of Serum 25-hydroxyvitamin D With Lipids: a Mendelian Randomization Approach of the HUNT Study. Eur J Epidemiol. 2019;34(1):57-66. PubMed PMID: 30465296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study. AU - Mai,Xiao-Mei, AU - Videm,Vibeke, AU - Sheehan,Nuala A, AU - Chen,Yue, AU - Langhammer,Arnulf, AU - Sun,Yi-Qian, Y1 - 2018/11/21/ PY - 2018/08/12/received PY - 2018/11/16/accepted PY - 2018/11/23/pubmed PY - 2019/4/13/medline PY - 2018/11/23/entrez KW - Cholesterol KW - High-density lipoprotein (HDL) KW - Lipid KW - Low-density lipoprotein (LDL) KW - Mendelian randomization KW - Serum 25-hydroxyvitamin D [25(OH)D] KW - Single-nucleotide polymorphisms KW - Triglycerides KW - Vitamin D SP - 57 EP - 66 JF - European journal of epidemiology JO - Eur J Epidemiol VL - 34 IS - 1 N2 - Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56,435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on the allele score were performed to assess the presence of causal associations of serum 25(OH)D with the lipids. To quantify the causal effects, the inverse-variance weighted method was used for calculating MR estimates based on summarized data of individual single-nucleotide polymorphisms. The MR estimate with 95% confidence interval (CI) represents percentage difference in the lipid level per genetically determined 25 nmol/L increase in 25(OH)D. The 25(OH)D allele score demonstrated a clear association with high-density lipoprotein (HDL) cholesterol (p = 0.007) but no association with total or non-HDL cholesterol or triglycerides (p ≥ 0.27). The MR estimate showed 2.52% (95% CI 0.79-4.25%) increase in HDL cholesterol per genetically determined 25 nmol/L increase in 25(OH)D, which was stronger than the corresponding estimate of 1.83% (95% CI 0.85-2.81%) from the observational analysis. The MR estimates for total cholesterol (0.60%, 95% CI - 0.73 to 1.94%), non-HDL cholesterol (0.04%, 95% CI - 1.79 to 1.88%) and triglycerides (- 2.74%, 95% CI - 6.16 to 0.67%) showed no associations. MR analysis of data from a population-based cohort suggested a causal and positive association between serum 25(OH)D and HDL cholesterol. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/30465296/Potential_causal_associations_of_serum_25_hydroxyvitamin_D_with_lipids:_a_Mendelian_randomization_approach_of_the_HUNT_study_ L2 - https://doi.org/10.1007/s10654-018-0465-x DB - PRIME DP - Unbound Medicine ER -