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Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis.
Phytomedicine. 2018 Nov 15; 50:247-256.P

Abstract

BACKGROUND

Withania somnifera Dunal, commonly known as Indian ginseng, has been in use since ancient times as anti-stress agent, aphrodisiac, for impotence and infertility treatment.

PURPOSE

To evaluate the efficacy and safety of W. somnifera treatment in infertile men.

STUDY DESIGN

An evidence-based systematic review and meta-analysis using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

METHODS

Published literature was searched in PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/).

RESULTS

Four clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) were included in the study. As only one RCT included, meta-analysis of RCT was not performed; however, systematically reviewed data demonstrated statistical (p ≤ .002 versus baseline) increase in sperm concentration (167%), semen volume (59%), and sperm motility (57%) in oligospermic males after 90 days of W. somnifera treatment, as well, serum testosterone (17%) and luteinizing hormone (34%) levels. Meta-analysis of observational (versus pre-treatment) studies showed that W. somnifera treatment significantly improved semen parameters (semen volume: mean difference [MD], 0.28 ml; 95% confidence interval [CI], 0.12 to 0.43; p = .0004; sperm concentration: MD, 13.57 million/ml; 95% CI, 11.12 to 16.01; p < .00001; sperm motility: MD, 8.50%; 95% CI, 7.36 to 9.63; p < .00001) with 14% of pregnancy outcome success rate in normozoospermic men. Meta-analysis findings also evidenced significant improvement in serum hormonal profile, oxidative biomarkers and antioxidant vitamins in seminal plasma. No adverse effects were reported in infertile men taking W. somnifera treatment.

CONCLUSION

Due to a small number of eligible studies, the available data, though promising, are too limited to provide novel and sufficiently robust evidence of the benefits of W. somnifera in male infertility. Additional RCTs of high quality with a larger sample size are warranted to further strength clinical use of W. somnifera in treating male factor infertility. Future research also needs to elucidate the molecular mechanism(s) of W. somnifera as well its active principles in male infertility.

Authors+Show Affiliations

Independent Researcher, Bidar 585402, Karnataka, India. Electronic address: sharanabasappadurg@yahoo.com.Independent Researcher, Bengaluru 560040, Karnataka, India.Independent Researcher, Bidar 585401, Karnataka, India.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30466985

Citation

Durg, Sharanbasappa, et al. "Withania Somnifera (Indian Ginseng) in Male Infertility: an Evidence-based Systematic Review and Meta-analysis." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 50, 2018, pp. 247-256.
Durg S, Shivaram SB, Bavage S. Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. Phytomedicine. 2018;50:247-256.
Durg, S., Shivaram, S. B., & Bavage, S. (2018). Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 50, 247-256. https://doi.org/10.1016/j.phymed.2017.11.011
Durg S, Shivaram SB, Bavage S. Withania Somnifera (Indian Ginseng) in Male Infertility: an Evidence-based Systematic Review and Meta-analysis. Phytomedicine. 2018 Nov 15;50:247-256. PubMed PMID: 30466985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. AU - Durg,Sharanbasappa, AU - Shivaram,Shivakumar Badamaranahalli, AU - Bavage,Sachin, Y1 - 2017/11/29/ PY - 2017/08/27/received PY - 2017/10/19/revised PY - 2017/11/29/accepted PY - 2018/11/24/entrez PY - 2018/11/24/pubmed PY - 2019/1/23/medline KW - Indian ginseng KW - Male infertility KW - Oxidative stress KW - Pregnancy rate KW - Systematic review SP - 247 EP - 256 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 50 N2 - BACKGROUND: Withania somnifera Dunal, commonly known as Indian ginseng, has been in use since ancient times as anti-stress agent, aphrodisiac, for impotence and infertility treatment. PURPOSE: To evaluate the efficacy and safety of W. somnifera treatment in infertile men. STUDY DESIGN: An evidence-based systematic review and meta-analysis using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. METHODS: Published literature was searched in PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/). RESULTS: Four clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) were included in the study. As only one RCT included, meta-analysis of RCT was not performed; however, systematically reviewed data demonstrated statistical (p ≤ .002 versus baseline) increase in sperm concentration (167%), semen volume (59%), and sperm motility (57%) in oligospermic males after 90 days of W. somnifera treatment, as well, serum testosterone (17%) and luteinizing hormone (34%) levels. Meta-analysis of observational (versus pre-treatment) studies showed that W. somnifera treatment significantly improved semen parameters (semen volume: mean difference [MD], 0.28 ml; 95% confidence interval [CI], 0.12 to 0.43; p = .0004; sperm concentration: MD, 13.57 million/ml; 95% CI, 11.12 to 16.01; p < .00001; sperm motility: MD, 8.50%; 95% CI, 7.36 to 9.63; p < .00001) with 14% of pregnancy outcome success rate in normozoospermic men. Meta-analysis findings also evidenced significant improvement in serum hormonal profile, oxidative biomarkers and antioxidant vitamins in seminal plasma. No adverse effects were reported in infertile men taking W. somnifera treatment. CONCLUSION: Due to a small number of eligible studies, the available data, though promising, are too limited to provide novel and sufficiently robust evidence of the benefits of W. somnifera in male infertility. Additional RCTs of high quality with a larger sample size are warranted to further strength clinical use of W. somnifera in treating male factor infertility. Future research also needs to elucidate the molecular mechanism(s) of W. somnifera as well its active principles in male infertility. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/30466985/Withania_somnifera__Indian_ginseng__in_male_infertility:_An_evidence_based_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(17)30172-1 DB - PRIME DP - Unbound Medicine ER -