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Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials.
Med Clin (Barc) 2019; 152(12):473-481MC

Abstract

BACKGROUND

Recent clinical studies have yielded controversial results regarding the effect of probiotics on lipid profiles. To assess the efficacy of probiotics in lowering serum lipid concentrations, we conducted a meta-analysis of randomized controlled trials (RCTs).

METHODS

Literature from the PubMed, Embase and Cochrane databases were searched and screened. The effects of probiotics on lipid profiles were assessed by mean difference (MD) and 95% confidence interval (CI). All included studies were analyzed using Review Manager 5.3 (Cochrane Collaboration, 2014).

RESULTS

A total of 19 RCTs, including 967 participants, met the inclusion criteria. Probiotic interventions reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) compared to controls (placebo or no treatment) by -0.25mmol/L (95% CI: -0.39, -0.12) and -0.17mmol/L (95% CI: -0.25, -0.09), respectively. No significant effects of probiotics on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were found. The effects of probiotics on decreasing TC and LDL-C levels were greater for longer intervention times, certain probiotic strains, and in younger mildly hypercholesterolaemic subjects.

CONCLUSION

This meta-analysis revealed that the use of probiotics can significantly lower TC and LDL-C levels in hypercholesterolaemic adults, which brings hope for reducing the risk factors for developing cardiovascular disease.

Authors+Show Affiliations

School of Medicine, Nankai University, Tianjin, China; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.School of Medicine, Nankai University, Tianjin, China; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China. Electronic address: sunny301ddc@126.com.

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

30467077

Citation

Mo, Rui, et al. "Effect of Probiotics On Lipid Profiles in Hypercholesterolaemic Adults: a Meta-analysis of Randomized Controlled Trials." Medicina Clinica, vol. 152, no. 12, 2019, pp. 473-481.
Mo R, Zhang X, Yang Y. Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials. Med Clin (Barc). 2019;152(12):473-481.
Mo, R., Zhang, X., & Yang, Y. (2019). Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials. Medicina Clinica, 152(12), pp. 473-481. doi:10.1016/j.medcli.2018.09.007.
Mo R, Zhang X, Yang Y. Effect of Probiotics On Lipid Profiles in Hypercholesterolaemic Adults: a Meta-analysis of Randomized Controlled Trials. Med Clin (Barc). 2019 Jun 21;152(12):473-481. PubMed PMID: 30467077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials. AU - Mo,Rui, AU - Zhang,Xingwei, AU - Yang,Yunsheng, Y1 - 2018/11/19/ PY - 2018/05/11/received PY - 2018/08/31/revised PY - 2018/09/06/accepted PY - 2018/11/24/pubmed PY - 2018/11/24/medline PY - 2018/11/24/entrez KW - Hipercolesterolemia KW - Hypercholesterolaemia KW - Meta-analysis KW - Metaanálisis KW - Probiotics KW - Probióticos SP - 473 EP - 481 JF - Medicina clinica JO - Med Clin (Barc) VL - 152 IS - 12 N2 - BACKGROUND: Recent clinical studies have yielded controversial results regarding the effect of probiotics on lipid profiles. To assess the efficacy of probiotics in lowering serum lipid concentrations, we conducted a meta-analysis of randomized controlled trials (RCTs). METHODS: Literature from the PubMed, Embase and Cochrane databases were searched and screened. The effects of probiotics on lipid profiles were assessed by mean difference (MD) and 95% confidence interval (CI). All included studies were analyzed using Review Manager 5.3 (Cochrane Collaboration, 2014). RESULTS: A total of 19 RCTs, including 967 participants, met the inclusion criteria. Probiotic interventions reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) compared to controls (placebo or no treatment) by -0.25mmol/L (95% CI: -0.39, -0.12) and -0.17mmol/L (95% CI: -0.25, -0.09), respectively. No significant effects of probiotics on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were found. The effects of probiotics on decreasing TC and LDL-C levels were greater for longer intervention times, certain probiotic strains, and in younger mildly hypercholesterolaemic subjects. CONCLUSION: This meta-analysis revealed that the use of probiotics can significantly lower TC and LDL-C levels in hypercholesterolaemic adults, which brings hope for reducing the risk factors for developing cardiovascular disease. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/30467077/Effect_of_probiotics_on_lipid_profiles_in_hypercholesterolaemic_adults:_A_meta_analysis_of_randomized_controlled_trials_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(18)30570-0 DB - PRIME DP - Unbound Medicine ER -
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