Tags

Type your tag names separated by a space and hit enter

Antioxidant therapies in attention deficit hyperactivity disorder.

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder among children and adults. Impulsivity, inattention, and hyperactivity are hallmark of ADHD. While ADHD is not on the autism spectrum, they are related in several ways as they have some overlapping symptoms. The pathogenesis of ADHD has so far remained enigmatic, however, there is some evidence suggesting critical association among ADHD and the level of oxidative stress which trigger cell membrane damage, changes in inner structure and function of proteins, as well as structural damage to DNA which eventually culminate into development of ADHD. Although stimulants as well as some classes of non-stimulants are used to ameliorate symptom of ADHD, various adverse effects have been associated with such compounds. To date, treatment of ADHD is done with a combination of medications, behavior modifications, psycho-education, family therapy and life-style changes. The American Academy of Pediatrics officially promote stimulant medications and/or behavior therapy as 'first line of therapy'. In addition to the presently therapeutic armamentarium, evidences are emerging on relevancy of natural products. There has been an interest on the therapeutic role of antioxidants in the treatment of ADHD. The present review aims to highlight the beneficiary role played by different antioxidants in mitigating the symptoms of ADHD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.

    ,

    Department of Food Science and Nutrition, Ageing and Dementia Research Group, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman, drmdessa@gmail.com.

    ,

    Department of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.

    ,

    Department of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.

    ,

    Research & Policy Department, World Innovation Summit for Health (WISH), Qatar Foundation, P.O. Box 5825, Doha, Qatar.

    ,

    Department of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.

    ,

    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

    ,

    Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India.

    ,

    Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India.

    ,

    Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.

    ,

    Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

    Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran.

    Source

    MeSH

    Adult
    Antioxidants
    Ascorbic Acid
    Attention Deficit Disorder with Hyperactivity
    Biological Products
    Child
    Glutathione
    Humans
    Oxidative Stress
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    30468658

    Citation

    Moghadas, Marzieh, et al. "Antioxidant Therapies in Attention Deficit Hyperactivity Disorder." Frontiers in Bioscience (Landmark Edition), vol. 24, 2019, pp. 313-333.
    Moghadas M, Essa MM, Ba-Omar T, et al. Antioxidant therapies in attention deficit hyperactivity disorder. Front Biosci (Landmark Ed). 2019;24:313-333.
    Moghadas, M., Essa, M. M., Ba-Omar, T., Al-Shehi, A., Qoronfleh, M. W., Eltayeb, E. A., ... Edalatmanesh, M. A. (2019). Antioxidant therapies in attention deficit hyperactivity disorder. Frontiers in Bioscience (Landmark Edition), 24, pp. 313-333.
    Moghadas M, et al. Antioxidant Therapies in Attention Deficit Hyperactivity Disorder. Front Biosci (Landmark Ed). 2019 01 1;24:313-333. PubMed PMID: 30468658.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant therapies in attention deficit hyperactivity disorder. AU - Moghadas,Marzieh, AU - Essa,Musthafa Mohamed, AU - Ba-Omar,Taher, AU - Al-Shehi,Aisha, AU - Qoronfleh,M Walid, AU - Eltayeb,Elsadig A, AU - Guillemin,Gilles J, AU - Manivasagam,Thamilarasan, AU - Justin-Thenmozhi,Arokiasamy, AU - Al-Bulushi,Buthaina Saleh, AU - Al-Adawi,Samir, AU - Edalatmanesh,Mohammad Amin, Y1 - 2019/01/01/ PY - 2018/11/24/entrez PY - 2018/11/24/pubmed PY - 2019/4/2/medline SP - 313 EP - 333 JF - Frontiers in bioscience (Landmark edition) JO - Front Biosci (Landmark Ed) VL - 24 N2 - Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder among children and adults. Impulsivity, inattention, and hyperactivity are hallmark of ADHD. While ADHD is not on the autism spectrum, they are related in several ways as they have some overlapping symptoms. The pathogenesis of ADHD has so far remained enigmatic, however, there is some evidence suggesting critical association among ADHD and the level of oxidative stress which trigger cell membrane damage, changes in inner structure and function of proteins, as well as structural damage to DNA which eventually culminate into development of ADHD. Although stimulants as well as some classes of non-stimulants are used to ameliorate symptom of ADHD, various adverse effects have been associated with such compounds. To date, treatment of ADHD is done with a combination of medications, behavior modifications, psycho-education, family therapy and life-style changes. The American Academy of Pediatrics officially promote stimulant medications and/or behavior therapy as 'first line of therapy'. In addition to the presently therapeutic armamentarium, evidences are emerging on relevancy of natural products. There has been an interest on the therapeutic role of antioxidants in the treatment of ADHD. The present review aims to highlight the beneficiary role played by different antioxidants in mitigating the symptoms of ADHD. SN - 1093-4715 UR - https://www.unboundmedicine.com/medline/citation/30468658/Antioxidant_therapies_in_attention_deficit_hyperactivity_disorder_ L2 - https://www.bioscience.org/2019/v24/af/4720/fulltext.htm DB - PRIME DP - Unbound Medicine ER -