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KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study.
J Glob Antimicrob Resist. 2019 06; 17:109-111.JG

Abstract

OBJECTIVES

KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonisation is a major risk factor for developing systemic infection. Ceftazidime/avibactam (CAZ/AVI) may have a role as decolonisation therapy in special situations.

METHODS

This was a retrospective, observational, multicentre study. The KPC-Kp gut decolonisation rate of CAZ/AVI-based therapy (Group A) was compared with other antimicrobial regimens (Group B) in patients with KPC-Kp infection.

RESULTS

Among 12 patients in Group A, 11 (91.7%) achieved gut decolonisation. None of the 24 patients of Group B were decolonised.

CONCLUSION

CAZ/AVI-based therapy could be useful in KPC-Kp gut decolonisation in high-risk patients.

Authors+Show Affiliations

Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy.First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy; Infectious Diseases Section, Department of Medicine, University of Perugia, Piazzale Gambuli 1, Perugia, Italy. Electronic address: carlop85@hotmail.it.Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.Infectious Diseases Section, Department of Mental Health and Public Medicine, University of Campania 'Luigi Vanvitelli', largo Madonna delle Grazie, Naples, Italy.Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.Microbiology and Virology Unit, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, Naples, Italy.Infectious Diseases Section, Department of Medicine, University of Perugia, Piazzale Gambuli 1, Perugia, Italy.Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.Infectious Diseases Division, Department of Medicine, University of Udine and Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy.First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Via G. Quagliariello 51, 80131 Naples, Italy.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30468915

Citation

Bassetti, Matteo, et al. "KPC-producing Klebsiella Pneumoniae Gut Decolonisation Following Ceftazidime/avibactam-based Combination Therapy: a Retrospective Observational Study." Journal of Global Antimicrobial Resistance, vol. 17, 2019, pp. 109-111.
Bassetti M, Carannante N, Pallotto C, et al. KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study. J Glob Antimicrob Resist. 2019;17:109-111.
Bassetti, M., Carannante, N., Pallotto, C., Righi, E., Di Caprio, G., Bernardo, M., Sodano, G., Mallardo, E., Francisci, D., Sartor, A., Graziano, E., & Tascini, C. (2019). KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study. Journal of Global Antimicrobial Resistance, 17, 109-111. https://doi.org/10.1016/j.jgar.2018.11.014
Bassetti M, et al. KPC-producing Klebsiella Pneumoniae Gut Decolonisation Following Ceftazidime/avibactam-based Combination Therapy: a Retrospective Observational Study. J Glob Antimicrob Resist. 2019;17:109-111. PubMed PMID: 30468915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study. AU - Bassetti,Matteo, AU - Carannante,Novella, AU - Pallotto,Carlo, AU - Righi,Elda, AU - Di Caprio,Giovanni, AU - Bernardo,Mariano, AU - Sodano,Giuseppe, AU - Mallardo,Enza, AU - Francisci,Daniela, AU - Sartor,Assunta, AU - Graziano,Elena, AU - Tascini,Carlo, Y1 - 2018/11/20/ PY - 2018/07/24/received PY - 2018/11/02/revised PY - 2018/11/06/accepted PY - 2018/11/24/pubmed PY - 2020/6/19/medline PY - 2018/11/24/entrez KW - Carbapenemase-producing Klebsiella pneumoniae KW - Ceftazidime KW - Ceftazidime/avibactam KW - Gut decolonisation KW - KPC SP - 109 EP - 111 JF - Journal of global antimicrobial resistance JO - J Glob Antimicrob Resist VL - 17 N2 - OBJECTIVES: KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonisation is a major risk factor for developing systemic infection. Ceftazidime/avibactam (CAZ/AVI) may have a role as decolonisation therapy in special situations. METHODS: This was a retrospective, observational, multicentre study. The KPC-Kp gut decolonisation rate of CAZ/AVI-based therapy (Group A) was compared with other antimicrobial regimens (Group B) in patients with KPC-Kp infection. RESULTS: Among 12 patients in Group A, 11 (91.7%) achieved gut decolonisation. None of the 24 patients of Group B were decolonised. CONCLUSION: CAZ/AVI-based therapy could be useful in KPC-Kp gut decolonisation in high-risk patients. SN - 2213-7173 UR - https://www.unboundmedicine.com/medline/citation/30468915/KPC_producing_Klebsiella_pneumoniae_gut_decolonisation_following_ceftazidime/avibactam_based_combination_therapy:_A_retrospective_observational_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-7165(18)30230-3 DB - PRIME DP - Unbound Medicine ER -