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Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays.
Environ Pollut. 2019 Jan; 244:861-870.EP

Abstract

Several organic contaminants (OCs) have been detected in bald eagle (Haliaeetus leucocephalus) nestling (eaglet) plasma in the upper Midwestern United States. Despite frequent and relatively high concentrations of OCs in eaglets, little is understood about potential biological effects associated with exposure. We screened an existing database of OC concentrations in eaglet plasma collected from the Midwestern United States against bioactivity information from the ToxCast database. ToxCast bioactivity information consists of concentrations expected to elicit responses across a range of biological space (e.g. cellular, developmental, etc.) obtained from a series of high throughput assays. We calculated exposure-activity ratios (EAR) by calculating the ratio of plasma concentrations to concentrations available in ToxCast. Bioactivity data were not available for all detected OCs. Therefore, our analysis provides estimates of potential bioactivity for 19 of the detected OCs in eaglet plasma. Perfluorooctanesulfonic acid (PFOS) EAR values were consistently the highest among all study areas. Maximum EAR values were ≥1 for PFOS, perfluorononanoic acid, and bisphenol A in 99.7, 0.53 and 0.26% of samples, indicating that some plasma concentrations were greater than what may be expected to elicit biological responses. About 125 gene targets, indicative of specific biological pathways, were identified as potentially being affected. Inhibition of several CYP genes, involved in xenobiotic metabolism, were most consistently identified. Other identified biological responses have potential implications for motor coordination, cardiac functions, behavior, and blood circulation. However, it is unclear what these results mean for bald eagles, given that ToxCast data are generated using mammalian-based endpoints. Despite uncertainties and limitations, this method of screening environmental data can be useful for informing future monitoring or research focused on understanding the occurrence and effects of OCs in bald eagles and other similarly-positioned trophic species.

Authors+Show Affiliations

U.S. Geological Survey, 2280 Woodale Drive, Mounds View, MN, 55112, United States. Electronic address: selliott@usgs.gov.U.S. National Park Service, Great Lakes Inventory & Monitoring Network, 2800 Lake Shore Drive East, Ashland, WI, 54806, United States. Electronic address: bill_route@nps.gov.U.S. Geological Survey, 8505 Research Way, Middleton, WI, 53562, United States. Electronic address: ldecicco@usgs.gov.U.S. National Park Service, Great Lakes Inventory & Monitoring Network, 2800 Lake Shore Drive East, Ashland, WI, 54806, United States. Electronic address: david_vanderMeulen@nps.gov.U.S. Geological Survey, 8505 Research Way, Middleton, WI, 53562, United States. Electronic address: srcorsi@usgs.gov.U.S. Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, MN, 55804, United States. Electronic address: blackwell.brett@epa.gov.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30469280

Citation

Elliott, Sarah M., et al. "Contaminants in Bald Eagles of the Upper Midwestern U.S.: a Framework for Prioritizing Future Research Based On In-vitro Bioassays." Environmental Pollution (Barking, Essex : 1987), vol. 244, 2019, pp. 861-870.
Elliott SM, Route WT, DeCicco LA, et al. Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays. Environ Pollut. 2019;244:861-870.
Elliott, S. M., Route, W. T., DeCicco, L. A., VanderMeulen, D. D., Corsi, S. R., & Blackwell, B. R. (2019). Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays. Environmental Pollution (Barking, Essex : 1987), 244, 861-870. https://doi.org/10.1016/j.envpol.2018.10.093
Elliott SM, et al. Contaminants in Bald Eagles of the Upper Midwestern U.S.: a Framework for Prioritizing Future Research Based On In-vitro Bioassays. Environ Pollut. 2019;244:861-870. PubMed PMID: 30469280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays. AU - Elliott,Sarah M, AU - Route,William T, AU - DeCicco,Laura A, AU - VanderMeulen,David D, AU - Corsi,Steven R, AU - Blackwell,Brett R, Y1 - 2018/10/24/ PY - 2018/06/26/received PY - 2018/10/19/revised PY - 2018/10/19/accepted PY - 2018/11/25/entrez PY - 2018/11/25/pubmed PY - 2019/1/16/medline KW - In-vitro bioactivity KW - Perfluorinated chemicals KW - Plasma KW - ToxCast SP - 861 EP - 870 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ. Pollut. VL - 244 N2 - Several organic contaminants (OCs) have been detected in bald eagle (Haliaeetus leucocephalus) nestling (eaglet) plasma in the upper Midwestern United States. Despite frequent and relatively high concentrations of OCs in eaglets, little is understood about potential biological effects associated with exposure. We screened an existing database of OC concentrations in eaglet plasma collected from the Midwestern United States against bioactivity information from the ToxCast database. ToxCast bioactivity information consists of concentrations expected to elicit responses across a range of biological space (e.g. cellular, developmental, etc.) obtained from a series of high throughput assays. We calculated exposure-activity ratios (EAR) by calculating the ratio of plasma concentrations to concentrations available in ToxCast. Bioactivity data were not available for all detected OCs. Therefore, our analysis provides estimates of potential bioactivity for 19 of the detected OCs in eaglet plasma. Perfluorooctanesulfonic acid (PFOS) EAR values were consistently the highest among all study areas. Maximum EAR values were ≥1 for PFOS, perfluorononanoic acid, and bisphenol A in 99.7, 0.53 and 0.26% of samples, indicating that some plasma concentrations were greater than what may be expected to elicit biological responses. About 125 gene targets, indicative of specific biological pathways, were identified as potentially being affected. Inhibition of several CYP genes, involved in xenobiotic metabolism, were most consistently identified. Other identified biological responses have potential implications for motor coordination, cardiac functions, behavior, and blood circulation. However, it is unclear what these results mean for bald eagles, given that ToxCast data are generated using mammalian-based endpoints. Despite uncertainties and limitations, this method of screening environmental data can be useful for informing future monitoring or research focused on understanding the occurrence and effects of OCs in bald eagles and other similarly-positioned trophic species. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/30469280/Contaminants_in_bald_eagles_of_the_upper_Midwestern_U_S_:_A_framework_for_prioritizing_future_research_based_on_in_vitro_bioassays_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(18)32916-6 DB - PRIME DP - Unbound Medicine ER -