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Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management.
Case Rep Endocrinol. 2018; 2018:3268010.CR

Abstract

The coexistence of thyroid functioning nodules and Graves' disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves' disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. The patient was diagnosed with Marine-Lenhart syndrome complicated by thyroid eye disease and was treated with methimazole followed by thyroidectomy and orbital decompression. We review the existing literature and propose criteria for the diagnosis and treatment of this condition.

Authors+Show Affiliations

Division of Internal Medicine, Department of Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL, USA.Division of Nuclear Medicine, Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

30473890

Citation

Neuman, Danielle, et al. "Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management." Case Reports in Endocrinology, vol. 2018, 2018, p. 3268010.
Neuman D, Kuker R, Vendrame F. Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management. Case Rep Endocrinol. 2018;2018:3268010.
Neuman, D., Kuker, R., & Vendrame, F. (2018). Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management. Case Reports in Endocrinology, 2018, 3268010. https://doi.org/10.1155/2018/3268010
Neuman D, Kuker R, Vendrame F. Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management. Case Rep Endocrinol. 2018;2018:3268010. PubMed PMID: 30473890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management. AU - Neuman,Danielle, AU - Kuker,Russ, AU - Vendrame,Francesco, Y1 - 2018/10/24/ PY - 2018/08/26/received PY - 2018/10/11/accepted PY - 2018/11/27/entrez PY - 2018/11/27/pubmed PY - 2018/11/27/medline SP - 3268010 EP - 3268010 JF - Case reports in endocrinology JO - Case Rep Endocrinol VL - 2018 N2 - The coexistence of thyroid functioning nodules and Graves' disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves' disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. The patient was diagnosed with Marine-Lenhart syndrome complicated by thyroid eye disease and was treated with methimazole followed by thyroidectomy and orbital decompression. We review the existing literature and propose criteria for the diagnosis and treatment of this condition. SN - 2090-6501 UR - https://www.unboundmedicine.com/medline/citation/30473890/Marine_Lenhart_Syndrome:_Case_Report_Diagnosis_and_Management_ L2 - https://doi.org/10.1155/2018/3268010 DB - PRIME DP - Unbound Medicine ER -
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