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Five Postmortem Case Reports with Qualitative Analysis of Cyclopropylfentanyl by LC-MS-MS.
J Anal Toxicol. 2019 May 01; 43(4):e1-e6.JA

Abstract

In January 2018, the Drug Enforcement Agency temporarily designated cyclopropylfentanyl as a Schedule I drug. Over the course of 5 months (December 2017-May 2018), the Nassau County Medical Examiner Toxicology Laboratory qualitatively identified and confirmed cyclopropylfentanyl in specimens obtained from five postmortem cases. We describe the five cases and include pertinent autopsy findings and decedent histories, along with results for cyclopropylfentanyl determined in postmortem cardiac blood. Samples were prepared by an alkaline liquid-liquid extraction, with sample pH adjusted to >9 and utilizing an extraction solvent consisting of 90:10 hexane:ethyl acetate. Instrumental analysis was achieved via liquid chromatography tandem mass spectrometry with a dual jetstream electrospray source operating in positive ion mode. Two ion transitions were monitored for each analyte of interest and the internal standard. The estimated concentration range of cyclopropylfentanyl in the reported cases was 5.6 to 82 ng/mL for five postmortem cardiac blood specimens. All five cases included cyclopropylfentanyl in the established cause of death.

Authors+Show Affiliations

Nassau County Medical Examiner, Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.Nassau County Medical Examiner, Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.Nassau County Medical Examiner, Department of Forensic Toxicology, 2251 Hempstead Turnpike-Building R, East Meadow, NY, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30476101

Citation

Fagiola, Michael, et al. "Five Postmortem Case Reports With Qualitative Analysis of Cyclopropylfentanyl By LC-MS-MS." Journal of Analytical Toxicology, vol. 43, no. 4, 2019, pp. e1-e6.
Fagiola M, Hahn T, Avella J. Five Postmortem Case Reports with Qualitative Analysis of Cyclopropylfentanyl by LC-MS-MS. J Anal Toxicol. 2019;43(4):e1-e6.
Fagiola, M., Hahn, T., & Avella, J. (2019). Five Postmortem Case Reports with Qualitative Analysis of Cyclopropylfentanyl by LC-MS-MS. Journal of Analytical Toxicology, 43(4), e1-e6. https://doi.org/10.1093/jat/bky094
Fagiola M, Hahn T, Avella J. Five Postmortem Case Reports With Qualitative Analysis of Cyclopropylfentanyl By LC-MS-MS. J Anal Toxicol. 2019 May 1;43(4):e1-e6. PubMed PMID: 30476101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five Postmortem Case Reports with Qualitative Analysis of Cyclopropylfentanyl by LC-MS-MS. AU - Fagiola,Michael, AU - Hahn,Timothy, AU - Avella,Joseph, PY - 2018/07/17/received PY - 2018/09/12/revised PY - 2018/10/23/accepted PY - 2018/11/27/pubmed PY - 2019/10/8/medline PY - 2018/11/27/entrez SP - e1 EP - e6 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 43 IS - 4 N2 - In January 2018, the Drug Enforcement Agency temporarily designated cyclopropylfentanyl as a Schedule I drug. Over the course of 5 months (December 2017-May 2018), the Nassau County Medical Examiner Toxicology Laboratory qualitatively identified and confirmed cyclopropylfentanyl in specimens obtained from five postmortem cases. We describe the five cases and include pertinent autopsy findings and decedent histories, along with results for cyclopropylfentanyl determined in postmortem cardiac blood. Samples were prepared by an alkaline liquid-liquid extraction, with sample pH adjusted to >9 and utilizing an extraction solvent consisting of 90:10 hexane:ethyl acetate. Instrumental analysis was achieved via liquid chromatography tandem mass spectrometry with a dual jetstream electrospray source operating in positive ion mode. Two ion transitions were monitored for each analyte of interest and the internal standard. The estimated concentration range of cyclopropylfentanyl in the reported cases was 5.6 to 82 ng/mL for five postmortem cardiac blood specimens. All five cases included cyclopropylfentanyl in the established cause of death. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/30476101/Five_Postmortem_Case_Reports_with_Qualitative_Analysis_of_Cyclopropylfentanyl_by_LC_MS_MS_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bky094 DB - PRIME DP - Unbound Medicine ER -