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Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis.
BMC Endocr Disord. 2018 Nov 26; 18(1):87.BE

Abstract

BACKGROUND

Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT.

METHODS

We recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models.

RESULTS

Fifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673-14.834, P < 0.001; OR 0.061, 95% CI 0.008-0.491, P = 0.009, respectively).

CONCLUSION

Our results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT.

Authors+Show Affiliations

Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China. jiaxingxujun@163.com.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30477467

Citation

Xu, Jun, et al. "Low Vitamin D Levels Are Associated With Cognitive Impairment in Patients With Hashimoto Thyroiditis." BMC Endocrine Disorders, vol. 18, no. 1, 2018, p. 87.
Xu J, Zhu XY, Sun H, et al. Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis. BMC Endocr Disord. 2018;18(1):87.
Xu, J., Zhu, X. Y., Sun, H., Xu, X. Q., Xu, S. A., Suo, Y., Cao, L. J., Zhou, Q., Yu, H. J., & Cao, W. Z. (2018). Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis. BMC Endocrine Disorders, 18(1), 87. https://doi.org/10.1186/s12902-018-0314-7
Xu J, et al. Low Vitamin D Levels Are Associated With Cognitive Impairment in Patients With Hashimoto Thyroiditis. BMC Endocr Disord. 2018 Nov 26;18(1):87. PubMed PMID: 30477467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis. AU - Xu,Jun, AU - Zhu,Xiang-Yun, AU - Sun,Hui, AU - Xu,Xiao-Qin, AU - Xu,Song-Ao, AU - Suo,Yuan, AU - Cao,Li-Jun, AU - Zhou,Qiang, AU - Yu,Hui-Jie, AU - Cao,Wei-Zhong, Y1 - 2018/11/26/ PY - 2018/08/13/received PY - 2018/11/08/accepted PY - 2018/11/28/entrez PY - 2018/11/28/pubmed PY - 2019/3/26/medline KW - Cognitive impairment KW - Hashimoto’s thyroiditis KW - Montreal cognitive assessment KW - Vitamin SP - 87 EP - 87 JF - BMC endocrine disorders JO - BMC Endocr Disord VL - 18 IS - 1 N2 - BACKGROUND: Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT. METHODS: We recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA). Subjects with a MoCA scores < 26 are considered as having mild cognitive impairment (MCI). Multivariate analysis was performed using logistic regression models. RESULTS: Fifty-five HT patients (28.4%) were diagnosed as having MCI. Patients with MCI had significantly lower 25(OH)D levels when compared with patients without MCI (33.9 ± 6.2 vs. 44.3 ± 9.6 nmol/L, P < 0.001). Significant differences in 25(OH)D quartiles of HT patients were observed between the patients with MCI and the patients without MCI (P < 0.001). In multivariate analyses, serum 25(OH)D levels (≤ 34.0 and ≥ 47.1 nmol/L) were significantly associated with cognitive impairment in patients with HT (OR 6.279, 95% CI 2.673-14.834, P < 0.001; OR 0.061, 95% CI 0.008-0.491, P = 0.009, respectively). CONCLUSION: Our results demonstrate an important association between serum vitamin D levels and cognitive impairment in patients with HT. SN - 1472-6823 UR - https://www.unboundmedicine.com/medline/citation/30477467/Low_vitamin_D_levels_are_associated_with_cognitive_impairment_in_patients_with_Hashimoto_thyroiditis_ L2 - https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0314-7 DB - PRIME DP - Unbound Medicine ER -