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Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study.
Complement Ther Med 2018; 41:47-51CT

Abstract

OBJECTIVES

The aim of the present study was to investigate the effect of crocetin on sleep architecture and subjective sleep parameters in healthy adult participants with mild sleep complaints.

DESIGN

A randomized, double-blind, placebo-controlled, crossover study with two intervention periods of 14 days each, separated by a 14-day wash-out period.

INTERVENTIONS

Thirty participants were randomly assigned to one of two sequence groups. Each group was given crocetin at 7.5 mg/day, or placebo. We measured objective sleep parameters using single-channel electroencephalography and assessed subjective sleep parameters using the Oguri-Shirakawa-Azumi Sleep Inventory, Middle-age and Aged version (OSA-MA).

MAIN OUTCOME MEASURES

Differences between crocetin and placebo in an objective sleep parameter (delta power), and OSA-MA scores.

RESULTS

Delta power was significantly increased with crocetin compared with placebo. There were no significant differences in the other sleep parameters, including sleep latency, sleep efficiency, total sleep time, and wake after sleep onset. Subjective scores for sleepiness on rising and feeling refreshed were significantly improved with crocetin compared with placebo.

CONCLUSIONS

The findings of the present study suggest that crocetin supplementation contributes to sleep maintenance, leading to improved subjective sleep quality.

Authors+Show Affiliations

Riken Vitamin Co., Ltd., 2-9-18 Kanda-Misakicho, Chiyoda-ku, Tokyo, 101-8370, Japan. Electronic address: nao_umigai@rike-vita.co.jp.Department of Nutritional Sciences for Well-Being, Kansai University of Welfare Sciences, 3-11-1 Asahigaoka, Kashiwara, Osaka, 582-0026, Japan.Oriental Ueno Detection Center, General Incorporated Association Oriental Occupational Health Association Tokyo Branch, 1-20-11 Ueno, Taito-ku, Tokyo, 110-0005, Japan.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30477864

Citation

Umigai, Naofumi, et al. "Effect of Crocetin On Quality of Sleep: a Randomized, Double-blind, Placebo-controlled, Crossover Study." Complementary Therapies in Medicine, vol. 41, 2018, pp. 47-51.
Umigai N, Takeda R, Mori A. Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study. Complement Ther Med. 2018;41:47-51.
Umigai, N., Takeda, R., & Mori, A. (2018). Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study. Complementary Therapies in Medicine, 41, pp. 47-51. doi:10.1016/j.ctim.2018.09.003.
Umigai N, Takeda R, Mori A. Effect of Crocetin On Quality of Sleep: a Randomized, Double-blind, Placebo-controlled, Crossover Study. Complement Ther Med. 2018;41:47-51. PubMed PMID: 30477864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study. AU - Umigai,Naofumi, AU - Takeda,Ryuji, AU - Mori,Atsuko, Y1 - 2018/09/08/ PY - 2018/07/24/received PY - 2018/09/03/revised PY - 2018/09/04/accepted PY - 2018/11/28/entrez PY - 2018/11/28/pubmed PY - 2019/3/5/medline KW - Crocetin KW - Electroencephalogram KW - Gardenia yellow KW - Sleep quality SP - 47 EP - 51 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 41 N2 - OBJECTIVES: The aim of the present study was to investigate the effect of crocetin on sleep architecture and subjective sleep parameters in healthy adult participants with mild sleep complaints. DESIGN: A randomized, double-blind, placebo-controlled, crossover study with two intervention periods of 14 days each, separated by a 14-day wash-out period. INTERVENTIONS: Thirty participants were randomly assigned to one of two sequence groups. Each group was given crocetin at 7.5 mg/day, or placebo. We measured objective sleep parameters using single-channel electroencephalography and assessed subjective sleep parameters using the Oguri-Shirakawa-Azumi Sleep Inventory, Middle-age and Aged version (OSA-MA). MAIN OUTCOME MEASURES: Differences between crocetin and placebo in an objective sleep parameter (delta power), and OSA-MA scores. RESULTS: Delta power was significantly increased with crocetin compared with placebo. There were no significant differences in the other sleep parameters, including sleep latency, sleep efficiency, total sleep time, and wake after sleep onset. Subjective scores for sleepiness on rising and feeling refreshed were significantly improved with crocetin compared with placebo. CONCLUSIONS: The findings of the present study suggest that crocetin supplementation contributes to sleep maintenance, leading to improved subjective sleep quality. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/30477864/Effect_of_crocetin_on_quality_of_sleep:_A_randomized_double_blind_placebo_controlled_crossover_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(18)30735-0 DB - PRIME DP - Unbound Medicine ER -