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Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single-center experience in Japan.
Transpl Infect Dis. 2019 Apr; 21(2):e13033.TI

Abstract

BACKGROUND

Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital.

METHODS

Our cross-sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti-HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme-linked immunosorbent assay and HEV RNA by reverse transcription polymerase chain reaction. Clinical data were collected from medical charts for all patients.

RESULTS

The prevalence of anti-HEV IgG was 8/184 (4.3%). Anti-HEV IgA, anti-HEV IgM, and HEV RNA were not detected in any patients. Compared to their anti-HEV IgG-negative counterparts, anti-HEV IgG-positive patients were significantly older at the time of transplantation, and they were more likely to receive kidneys from deceased donors. No significant differences in other characteristics such as the prevalence of primary cause of end-stage renal disease, blood transfusion, and immunosuppressive therapy use; liver and renal function; and the frequencies of hepatitis B and hepatitis C virus infection were observed according to the patients' anti-HEV IgG status.

CONCLUSION

HEV infection had no significant influence on the outcomes of kidney transplantation at our institution. However, HEV infection should be recognized in kidney transplant recipients similarly as hepatitis B and hepatitis C virus infection in cases of liver dysfunction.

Authors+Show Affiliations

Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Department of Gastroenterological Surgery, Tokyo Medical University Ibaraki Medical Center, Inashiki, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Japan.Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30481402

Citation

Nanmoku, Koji, et al. "Prevalence and Characteristics of Hepatitis E Virus Infection in Kidney Transplant Recipients: a Single-center Experience in Japan." Transplant Infectious Disease : an Official Journal of the Transplantation Society, vol. 21, no. 2, 2019, pp. e13033.
Nanmoku K, Owada Y, Oshiro Y, et al. Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single-center experience in Japan. Transpl Infect Dis. 2019;21(2):e13033.
Nanmoku, K., Owada, Y., Oshiro, Y., Kurosawa, A., Kubo, T., Shinzato, T., Shimizu, T., Kimura, T., Sakuma, Y., Ishikawa, N., Ohkohchi, N., Okamoto, H., & Yagisawa, T. (2019). Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single-center experience in Japan. Transplant Infectious Disease : an Official Journal of the Transplantation Society, 21(2), e13033. https://doi.org/10.1111/tid.13033
Nanmoku K, et al. Prevalence and Characteristics of Hepatitis E Virus Infection in Kidney Transplant Recipients: a Single-center Experience in Japan. Transpl Infect Dis. 2019;21(2):e13033. PubMed PMID: 30481402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single-center experience in Japan. AU - Nanmoku,Koji, AU - Owada,Yohei, AU - Oshiro,Yukio, AU - Kurosawa,Akira, AU - Kubo,Taro, AU - Shinzato,Takahiro, AU - Shimizu,Toshihiro, AU - Kimura,Takaaki, AU - Sakuma,Yasunaru, AU - Ishikawa,Nobuo, AU - Ohkohchi,Nobuhiro, AU - Okamoto,Hiroaki, AU - Yagisawa,Takashi, Y1 - 2018/12/14/ PY - 2018/08/02/received PY - 2018/11/06/revised PY - 2018/11/15/accepted PY - 2018/11/28/pubmed PY - 2019/5/3/medline PY - 2018/11/28/entrez KW - cross-sectional study KW - hepatitis E virus KW - kidney transplantation SP - e13033 EP - e13033 JF - Transplant infectious disease : an official journal of the Transplantation Society JO - Transpl Infect Dis VL - 21 IS - 2 N2 - BACKGROUND: Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital. METHODS: Our cross-sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti-HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme-linked immunosorbent assay and HEV RNA by reverse transcription polymerase chain reaction. Clinical data were collected from medical charts for all patients. RESULTS: The prevalence of anti-HEV IgG was 8/184 (4.3%). Anti-HEV IgA, anti-HEV IgM, and HEV RNA were not detected in any patients. Compared to their anti-HEV IgG-negative counterparts, anti-HEV IgG-positive patients were significantly older at the time of transplantation, and they were more likely to receive kidneys from deceased donors. No significant differences in other characteristics such as the prevalence of primary cause of end-stage renal disease, blood transfusion, and immunosuppressive therapy use; liver and renal function; and the frequencies of hepatitis B and hepatitis C virus infection were observed according to the patients' anti-HEV IgG status. CONCLUSION: HEV infection had no significant influence on the outcomes of kidney transplantation at our institution. However, HEV infection should be recognized in kidney transplant recipients similarly as hepatitis B and hepatitis C virus infection in cases of liver dysfunction. SN - 1399-3062 UR - https://www.unboundmedicine.com/medline/citation/30481402/Prevalence_and_characteristics_of_hepatitis_E_virus_infection_in_kidney_transplant_recipients:_A_single_center_experience_in_Japan_ L2 - https://doi.org/10.1111/tid.13033 DB - PRIME DP - Unbound Medicine ER -