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Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia.
World Neurosurg. 2019 Mar; 123:e211-e217.WN

Abstract

OBJECTIVE

To compare the efficacy and side effects of bilateral globus pallidus internus (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) in the same patient with primary dystonia.

METHODS

Patients with primary dystonia from the department of functional neurosurgery in Beijing Tiantan Hospital were recruited for the study. Four electrodes were bilaterally implanted in the GPi and STN. A trial stimulation was applied to determine the preliminary therapeutic effects. Five evaluations were conducted: preoperative, postoperative (before stimulation), after sham stimulation, and after stimulation for 24 hours of GPi and STN using optimal parameters, judged by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS).

RESULTS

The BFMDRS movement score decreased after both short-term GPi stimulation (from 15.3 ± 6.9 to 7.6 ± 4.2, P < 0.05) and short-term STN stimulation (from 15.3 ± 6.9 to 8.6 ± 5.0, P < 0.05). There were significant reductions in facial (eyes and mouth) movement scores after short-term GPi and STN DBS compared with baseline (P < 0.05), but not in cervical symptoms (P > 0.05). The cervical symptoms of tonic dystonia had an improvement after long-term DBS treatment (P < 0.05). There were more adverse events with STN DBS; however, most side effects could be ameliorated by adjusting stimulation parameters.

CONCLUSIONS

Both short-term GPi and STN stimulation improved the motor symptoms of dystonia, but there was no significant difference between GPi DBS and STN DBS. There were more side effects associated with STN stimulation.

Authors+Show Affiliations

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neurostimulation, Beijing, China. Electronic address: zjguo73@126.com.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30481618

Citation

Liu, Yuye, et al. "Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia." World Neurosurgery, vol. 123, 2019, pp. e211-e217.
Liu Y, Zhu G, Jiang Y, et al. Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia. World Neurosurg. 2019;123:e211-e217.
Liu, Y., Zhu, G., Jiang, Y., Wang, X., Chen, Y., Meng, F., Zhang, K., Yang, A., Liu, H., Zhang, X., & Zhang, J. (2019). Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia. World Neurosurgery, 123, e211-e217. https://doi.org/10.1016/j.wneu.2018.11.137
Liu Y, et al. Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia. World Neurosurg. 2019;123:e211-e217. PubMed PMID: 30481618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Short-Term Stimulation of the Globus Pallidus Interna and Subthalamic Nucleus for Treatment of Primary Dystonia. AU - Liu,Yuye, AU - Zhu,Guanyu, AU - Jiang,Yin, AU - Wang,Xiu, AU - Chen,Yingchuan, AU - Meng,Fangang, AU - Zhang,Kai, AU - Yang,Anchao, AU - Liu,Huanguang, AU - Zhang,Xin, AU - Zhang,Jianguo, Y1 - 2018/11/24/ PY - 2018/05/10/received PY - 2018/11/14/revised PY - 2018/11/16/accepted PY - 2018/11/28/pubmed PY - 2019/4/4/medline PY - 2018/11/28/entrez KW - Deep brain stimulation (DBS) KW - Globus pallidus internus (GPi) KW - Primary dystonia KW - Subthalamic nucleus (STN) SP - e211 EP - e217 JF - World neurosurgery JO - World Neurosurg VL - 123 N2 - OBJECTIVE: To compare the efficacy and side effects of bilateral globus pallidus internus (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) in the same patient with primary dystonia. METHODS: Patients with primary dystonia from the department of functional neurosurgery in Beijing Tiantan Hospital were recruited for the study. Four electrodes were bilaterally implanted in the GPi and STN. A trial stimulation was applied to determine the preliminary therapeutic effects. Five evaluations were conducted: preoperative, postoperative (before stimulation), after sham stimulation, and after stimulation for 24 hours of GPi and STN using optimal parameters, judged by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). RESULTS: The BFMDRS movement score decreased after both short-term GPi stimulation (from 15.3 ± 6.9 to 7.6 ± 4.2, P < 0.05) and short-term STN stimulation (from 15.3 ± 6.9 to 8.6 ± 5.0, P < 0.05). There were significant reductions in facial (eyes and mouth) movement scores after short-term GPi and STN DBS compared with baseline (P < 0.05), but not in cervical symptoms (P > 0.05). The cervical symptoms of tonic dystonia had an improvement after long-term DBS treatment (P < 0.05). There were more adverse events with STN DBS; however, most side effects could be ameliorated by adjusting stimulation parameters. CONCLUSIONS: Both short-term GPi and STN stimulation improved the motor symptoms of dystonia, but there was no significant difference between GPi DBS and STN DBS. There were more side effects associated with STN stimulation. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/30481618/Comparison_of_Short_Term_Stimulation_of_the_Globus_Pallidus_Interna_and_Subthalamic_Nucleus_for_Treatment_of_Primary_Dystonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(18)32696-2 DB - PRIME DP - Unbound Medicine ER -