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Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island.
Microb Drug Resist. 2019 May; 25(4):577-581.MD

Abstract

Aims:

Although the cases of macrolide-resistant Mycoplasma pneumoniae (MRMP) have been increasing substantially among children, there are very few studies that have focused on MRMP in adults. This study aimed to investigate the prevalence and clinical features of community-acquired pneumonia (CAP) caused by MRMP from adults in Jeju Island, Korea.

Methods:

We retrospectively recruited adult patients with CAP in whom M. pneumoniae infections had been confirmed for a 7-year period. Macrolide resistance was determined by identifying a mutation in the 23S rRNA gene using PCR.

Results:

In total, 70 subjects were included. Their mean age was 46.1 years and 36 (51.4%) were women. Only two isolates (2.9%) carried macrolide resistance mutations in the 23S rRNA gene, and all the mutations were A2063G transitions. No significant differences were observed in age, comorbidities, symptoms, duration of fever, and length of hospital stay between the MRMP and macrolide-sensitive Mycoplasma pneumoniae groups. The number of involved pulmonary lobes was greater in the MRMP group (3.50 vs. 1.44, p = 0.008).

Conclusion:

The prevalence of CAP caused by MRMP was relatively low in adults in Jeju Island. Patients with MRMP pneumonia tended to have multilobar pneumonic infiltrates.

Authors+Show Affiliations

1 Department of Pediatrics, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.2 Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.3 Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.4 Department of Laboratory Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.2 Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30484744

Citation

Choi, Jae Hong, et al. "Prevalence and Clinical Features of Community-Acquired Pneumonia Caused By Macrolide-Resistant Mycoplasma Pneumoniae Isolated From Adults in Jeju Island." Microbial Drug Resistance (Larchmont, N.Y.), vol. 25, no. 4, 2019, pp. 577-581.
Choi JH, Seong GM, Ko Y, et al. Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island. Microb Drug Resist. 2019;25(4):577-581.
Choi, J. H., Seong, G. M., Ko, Y., Kim, Y. R., & Kim, C. (2019). Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island. Microbial Drug Resistance (Larchmont, N.Y.), 25(4), 577-581. https://doi.org/10.1089/mdr.2018.0295
Choi JH, et al. Prevalence and Clinical Features of Community-Acquired Pneumonia Caused By Macrolide-Resistant Mycoplasma Pneumoniae Isolated From Adults in Jeju Island. Microb Drug Resist. 2019;25(4):577-581. PubMed PMID: 30484744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Clinical Features of Community-Acquired Pneumonia Caused by Macrolide-Resistant Mycoplasma pneumoniae Isolated from Adults in Jeju Island. AU - Choi,Jae Hong, AU - Seong,Gil Myeong, AU - Ko,Yousang, AU - Kim,Young Ree, AU - Kim,Changhwan, Y1 - 2018/11/28/ PY - 2018/11/30/pubmed PY - 2019/11/20/medline PY - 2018/11/29/entrez KW - KW - drug resistance KW - macrolides SP - 577 EP - 581 JF - Microbial drug resistance (Larchmont, N.Y.) JO - Microb Drug Resist VL - 25 IS - 4 N2 - Aims: Although the cases of macrolide-resistant Mycoplasma pneumoniae (MRMP) have been increasing substantially among children, there are very few studies that have focused on MRMP in adults. This study aimed to investigate the prevalence and clinical features of community-acquired pneumonia (CAP) caused by MRMP from adults in Jeju Island, Korea. Methods: We retrospectively recruited adult patients with CAP in whom M. pneumoniae infections had been confirmed for a 7-year period. Macrolide resistance was determined by identifying a mutation in the 23S rRNA gene using PCR. Results: In total, 70 subjects were included. Their mean age was 46.1 years and 36 (51.4%) were women. Only two isolates (2.9%) carried macrolide resistance mutations in the 23S rRNA gene, and all the mutations were A2063G transitions. No significant differences were observed in age, comorbidities, symptoms, duration of fever, and length of hospital stay between the MRMP and macrolide-sensitive Mycoplasma pneumoniae groups. The number of involved pulmonary lobes was greater in the MRMP group (3.50 vs. 1.44, p = 0.008). Conclusion: The prevalence of CAP caused by MRMP was relatively low in adults in Jeju Island. Patients with MRMP pneumonia tended to have multilobar pneumonic infiltrates. SN - 1931-8448 UR - https://www.unboundmedicine.com/medline/citation/30484744/Prevalence_and_Clinical_Features_of_Community_Acquired_Pneumonia_Caused_by_Macrolide_Resistant_Mycoplasma_pneumoniae_Isolated_from_Adults_in_Jeju_Island_ L2 - https://www.liebertpub.com/doi/10.1089/mdr.2018.0295?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -