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[The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis].
Zhonghua Nei Ke Za Zhi. 2018 Dec 01; 57(12):912-916.ZN

Abstract

Objective:

To investigate the clinical features and risk factors for acute kidney injury (AKI) in patients with cirrhosis.

Methods:

A total of 1 165 hospitalized patients with chronic liver diseases were enrolled. Among them, 94 patients had chronic hepatitis, while 1 071 patients were diagnosed as cirrhosis. The clinical data, renal and liver function were retrospectively analyzed. AKI was determined according to the criteria proposed by International Club of Ascites. Compared with chronic hepatitis group, the clinical features and risk factors for AKI in patients with cirrhosis were evaluated using logistic regression.

Results:

The prevalence of AKI in chronic hepatitis and cirrhosis were 4.26%(4/94) and 11.11% (119/1 071), respectively. The AKI rates in patients with liver function Child A, B and C were 3.77%(18/377), 10.88% (41/377) and 27.65%(60/217), respectively. The independent risk factors for AKI in cirrhotic patients included infections (OR=5.37, 95%CI 3.24-8.90, P=0.000), acute on chronic liver failure (ACLF, OR=4.55, 95%CI 2.60-7.98, P=0.000) and diabetes (OR=1.70, 95%CI 1.07-2.70, P=0.024). The mortality rate of cirrhotic patients with AKI was 36.97% within 2 months. Moreover, the mortality rates in stage Ⅰ, Ⅱ and Ⅲ AKI were 20.31%, 36.00% and 73.33%, respectively.

Conclusions:

The mortality rate of cirrhotic patients with stage Ⅲ AKI is extremely high. Infections, ACLF and diabetes are the independent risk factors for AKI in patients with cirrhosis.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30486560

Citation

Wang, W J., et al. "[The Clinical Characteristics and Risk Factors for Acute Kidney Injury in Patients With Cirrhosis]." Zhonghua Nei Ke Za Zhi, vol. 57, no. 12, 2018, pp. 912-916.
Wang WJ, Song Q, Ding HG. [The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis]. Zhonghua Nei Ke Za Zhi. 2018;57(12):912-916.
Wang, W. J., Song, Q., & Ding, H. G. (2018). [The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis]. Zhonghua Nei Ke Za Zhi, 57(12), 912-916. https://doi.org/10.3760/cma.j.issn.0578-1426.2018.12.007
Wang WJ, Song Q, Ding HG. [The Clinical Characteristics and Risk Factors for Acute Kidney Injury in Patients With Cirrhosis]. Zhonghua Nei Ke Za Zhi. 2018 Dec 1;57(12):912-916. PubMed PMID: 30486560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis]. AU - Wang,W J, AU - Song,Q, AU - Ding,H G, PY - 2018/11/30/entrez PY - 2018/11/30/pubmed PY - 2019/1/19/medline KW - Acute kidney injury KW - Liver cirrhosis KW - Prognosis KW - Risk factors SP - 912 EP - 916 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 57 IS - 12 N2 - Objective: To investigate the clinical features and risk factors for acute kidney injury (AKI) in patients with cirrhosis. Methods: A total of 1 165 hospitalized patients with chronic liver diseases were enrolled. Among them, 94 patients had chronic hepatitis, while 1 071 patients were diagnosed as cirrhosis. The clinical data, renal and liver function were retrospectively analyzed. AKI was determined according to the criteria proposed by International Club of Ascites. Compared with chronic hepatitis group, the clinical features and risk factors for AKI in patients with cirrhosis were evaluated using logistic regression. Results: The prevalence of AKI in chronic hepatitis and cirrhosis were 4.26%(4/94) and 11.11% (119/1 071), respectively. The AKI rates in patients with liver function Child A, B and C were 3.77%(18/377), 10.88% (41/377) and 27.65%(60/217), respectively. The independent risk factors for AKI in cirrhotic patients included infections (OR=5.37, 95%CI 3.24-8.90, P=0.000), acute on chronic liver failure (ACLF, OR=4.55, 95%CI 2.60-7.98, P=0.000) and diabetes (OR=1.70, 95%CI 1.07-2.70, P=0.024). The mortality rate of cirrhotic patients with AKI was 36.97% within 2 months. Moreover, the mortality rates in stage Ⅰ, Ⅱ and Ⅲ AKI were 20.31%, 36.00% and 73.33%, respectively. Conclusions: The mortality rate of cirrhotic patients with stage Ⅲ AKI is extremely high. Infections, ACLF and diabetes are the independent risk factors for AKI in patients with cirrhosis. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/30486560/[The_clinical_characteristics_and_risk_factors_for_acute_kidney_injury_in_patients_with_cirrhosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0578-1426&year=2018&vol=57&issue=12&fpage=912 DB - PRIME DP - Unbound Medicine ER -