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[Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody].
Rinsho Shinkeigaku. 2018 Dec 21; 58(12):767-770.RS

Abstract

A 27-year-old man developed acute encephalitis with headache, fever, seizures, and aphasia. Analysis of cerebrospinal fluid showed elevated levels of cell counts and protein. A brain MRI demonstrated increased FLAIR signals in the left cerebral cortex with cortical swelling. An MRA also showed mild vasodilatation of the left middle cerebral artery branches. After admission, severe psychomotor excitement developed. Immunotherapy with intravenous high-dose steroid and subsequent oral steroid was successful, and the patient returned to premorbid working position. Repeated MRI study showed complete resolution. Serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive, while anti-aquaporin-4 antibody, anti-N-methyl-D-aspartate (NMDA) receptor antibody, and other autoimmune antibodies were all negative. There were no relapses at final follow-up of 8 months after onset. Cerebral cortical encephalitis with unknown etiology can occur associated with anti-MOG antibody, and anti-MOG antibody may play certain role in the pathogenesis.

Authors+Show Affiliations

Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.Department of Neurology, Tohoku University Graduate School of Medicine. Department of Neurology, National Hospital Organization, Yonezawa Hospital.Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.

Pub Type(s)

Case Reports
Journal Article

Language

jpn

PubMed ID

30487364

Citation

Adachi, Hiroshi, et al. "[Cerebral Cortical Encephalitis With Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibody]." Rinsho Shinkeigaku = Clinical Neurology, vol. 58, no. 12, 2018, pp. 767-770.
Adachi H, Ide Y, Takahashi T, et al. [Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody]. Rinsho Shinkeigaku. 2018;58(12):767-770.
Adachi, H., Ide, Y., Takahashi, T., Yoneda, Y., & Kageyama, Y. (2018). [Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody]. Rinsho Shinkeigaku = Clinical Neurology, 58(12), 767-770. https://doi.org/10.5692/clinicalneurol.cn-001224
Adachi H, et al. [Cerebral Cortical Encephalitis With Anti-myelin Oligodendrocyte Glycoprotein (MOG) Antibody]. Rinsho Shinkeigaku. 2018 Dec 21;58(12):767-770. PubMed PMID: 30487364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody]. AU - Adachi,Hiroshi, AU - Ide,Yukiko, AU - Takahashi,Toshiyuki, AU - Yoneda,Yukihiro, AU - Kageyama,Yasufumi, Y1 - 2018/11/29/ PY - 2018/11/30/pubmed PY - 2019/1/31/medline PY - 2018/11/30/entrez KW - cerebral cortex KW - encephalitis KW - myelin oligodendrocyte glycoprotein (MOG) KW - seizure SP - 767 EP - 770 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 58 IS - 12 N2 - A 27-year-old man developed acute encephalitis with headache, fever, seizures, and aphasia. Analysis of cerebrospinal fluid showed elevated levels of cell counts and protein. A brain MRI demonstrated increased FLAIR signals in the left cerebral cortex with cortical swelling. An MRA also showed mild vasodilatation of the left middle cerebral artery branches. After admission, severe psychomotor excitement developed. Immunotherapy with intravenous high-dose steroid and subsequent oral steroid was successful, and the patient returned to premorbid working position. Repeated MRI study showed complete resolution. Serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive, while anti-aquaporin-4 antibody, anti-N-methyl-D-aspartate (NMDA) receptor antibody, and other autoimmune antibodies were all negative. There were no relapses at final follow-up of 8 months after onset. Cerebral cortical encephalitis with unknown etiology can occur associated with anti-MOG antibody, and anti-MOG antibody may play certain role in the pathogenesis. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/30487364/[Cerebral_cortical_encephalitis_with_anti_myelin_oligodendrocyte_glycoprotein__MOG__antibody]_ L2 - https://dx.doi.org/10.5692/clinicalneurol.cn-001224 DB - PRIME DP - Unbound Medicine ER -