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Use of extract of Ruscus aculeatus in venous disease in the lower limbs.
Drugs Exp Clin Res. 1988; 14(4):277-83.DE

Abstract

The effectiveness and tolerability of a venotropic drug (RAES) composed of an extract of Ruscus aculeatus (16.5 mg), hesperidin (75 mg) and ascorbic acid (50 mg) were evaluated in 40 patients (30 female, 10 male) aged between 28 and 74 years, suffering from chronic phlebopathy of the lower limbs. The cross-over, double-blind trial involved two periods of treatment of 2 months with the drug (2 capsules, 3 times/day) or with placebo, and an interim period of 15 days for wash-out. An overall tendency for improvement occurred that was more distinct during the periods of treatment with the drug. In fact, symptoms and plethysmographic parameters (in particular MVIV 40 and 60) immediately changed significantly in correspondence with the administration of RAES. The biological and clinical tolerability were excellent.

Authors+Show Affiliations

Institute of Medical Pathology, Unviersity of Siena, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3048951

Citation

Cappelli, R, et al. "Use of Extract of Ruscus Aculeatus in Venous Disease in the Lower Limbs." Drugs Under Experimental and Clinical Research, vol. 14, no. 4, 1988, pp. 277-83.
Cappelli R, Nicora M, Di Perri T. Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Exp Clin Res. 1988;14(4):277-83.
Cappelli, R., Nicora, M., & Di Perri, T. (1988). Use of extract of Ruscus aculeatus in venous disease in the lower limbs. Drugs Under Experimental and Clinical Research, 14(4), 277-83.
Cappelli R, Nicora M, Di Perri T. Use of Extract of Ruscus Aculeatus in Venous Disease in the Lower Limbs. Drugs Exp Clin Res. 1988;14(4):277-83. PubMed PMID: 3048951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of extract of Ruscus aculeatus in venous disease in the lower limbs. AU - Cappelli,R, AU - Nicora,M, AU - Di Perri,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 277 EP - 83 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 14 IS - 4 N2 - The effectiveness and tolerability of a venotropic drug (RAES) composed of an extract of Ruscus aculeatus (16.5 mg), hesperidin (75 mg) and ascorbic acid (50 mg) were evaluated in 40 patients (30 female, 10 male) aged between 28 and 74 years, suffering from chronic phlebopathy of the lower limbs. The cross-over, double-blind trial involved two periods of treatment of 2 months with the drug (2 capsules, 3 times/day) or with placebo, and an interim period of 15 days for wash-out. An overall tendency for improvement occurred that was more distinct during the periods of treatment with the drug. In fact, symptoms and plethysmographic parameters (in particular MVIV 40 and 60) immediately changed significantly in correspondence with the administration of RAES. The biological and clinical tolerability were excellent. SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/3048951/Use_of_extract_of_Ruscus_aculeatus_in_venous_disease_in_the_lower_limbs_ L2 - https://medlineplus.gov/varicoseveins.html DB - PRIME DP - Unbound Medicine ER -