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Inhaled corticosteroids might not increase the risk of pneumonia in patients with chronic obstructive pulmonary disease in Japan.
Int J Chron Obstruct Pulmon Dis. 2018; 13:3503-3509.IJ

Abstract

Background

The use of inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD) decreases the frequency of COPD exacerbations. Recently, pneumonia was reported as a complication of ICS in patients with COPD. However, there have been few reports concerning the relationship between ICS and pneumonia in Japan. Moreover, there is little information on the types of ICS.

Patients and methods

To clarify these issues, we investigated the occurrence of pneumonia in Japanese patients with COPD. We retrospectively investigated the occurrence of pneumonia in patients with COPD in our hospital from January 2009 to August 2013. Morbidity and mortality, ICS use, age, sex, and COPD classification were investigated. A group of patients with COPD who received ICS and a group of patients with COPD who did not receive ICS were compared each other.

Results

Fifty-one patients developed pneumonia among 639 (7.98%) patients with COPD. Among 252 ICS-treated patients with COPD, 13 (5.16%) developed pneumonia, and among 387 ICS-untreated patients with COPD, 38 (9.82%) developed pneumonia. The mortality rate in ICS-treated patients with COPD was 7.7%, while that in ICS-untreated patients was 10.5% (P=0.767). Fluticasone/salmeterol use tended to show a higher risk of pneumonia than budesonide/formoterol use. The use of ICS did not increase the risk of pneumonia or mortality due to pneumonia in Japanese patients with COPD.

Conclusion

ICS might not increase the risk of pneumonia in Japanese patients with COPD. In regard to pneumonia, ICS can be safely used in Japanese patients with COPD. Because there are apparent differences in lung diseases among races, appropriate treatment should be investigated in each country.

Authors+Show Affiliations

Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan, mfujita@fukuoka-u.ac.jp.Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan, mfujita@fukuoka-u.ac.jp.Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan, mfujita@fukuoka-u.ac.jp.Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan, mfujita@fukuoka-u.ac.jp.Department of Respiratory Medicine, Fukuoka University Hospital, Nanakuma, Jonanku, Fukuoka, Japan, mfujita@fukuoka-u.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30498340

Citation

Hirano, Ryosuke, et al. "Inhaled Corticosteroids Might Not Increase the Risk of Pneumonia in Patients With Chronic Obstructive Pulmonary Disease in Japan." International Journal of Chronic Obstructive Pulmonary Disease, vol. 13, 2018, pp. 3503-3509.
Hirano R, Fujita M, Matsumoto T, et al. Inhaled corticosteroids might not increase the risk of pneumonia in patients with chronic obstructive pulmonary disease in Japan. Int J Chron Obstruct Pulmon Dis. 2018;13:3503-3509.
Hirano, R., Fujita, M., Matsumoto, T., On, R., & Watanabe, K. (2018). Inhaled corticosteroids might not increase the risk of pneumonia in patients with chronic obstructive pulmonary disease in Japan. International Journal of Chronic Obstructive Pulmonary Disease, 13, 3503-3509. https://doi.org/10.2147/COPD.S180349
Hirano R, et al. Inhaled Corticosteroids Might Not Increase the Risk of Pneumonia in Patients With Chronic Obstructive Pulmonary Disease in Japan. Int J Chron Obstruct Pulmon Dis. 2018;13:3503-3509. PubMed PMID: 30498340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhaled corticosteroids might not increase the risk of pneumonia in patients with chronic obstructive pulmonary disease in Japan. AU - Hirano,Ryosuke, AU - Fujita,Masaki, AU - Matsumoto,Takemasa, AU - On,Rintaro, AU - Watanabe,Kentaro, Y1 - 2018/10/23/ PY - 2018/12/1/entrez PY - 2018/12/1/pubmed PY - 2019/4/10/medline KW - COPD KW - adverse event KW - inhaled corticosteroid KW - pneumonia SP - 3503 EP - 3509 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 13 N2 - Background: The use of inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD) decreases the frequency of COPD exacerbations. Recently, pneumonia was reported as a complication of ICS in patients with COPD. However, there have been few reports concerning the relationship between ICS and pneumonia in Japan. Moreover, there is little information on the types of ICS. Patients and methods: To clarify these issues, we investigated the occurrence of pneumonia in Japanese patients with COPD. We retrospectively investigated the occurrence of pneumonia in patients with COPD in our hospital from January 2009 to August 2013. Morbidity and mortality, ICS use, age, sex, and COPD classification were investigated. A group of patients with COPD who received ICS and a group of patients with COPD who did not receive ICS were compared each other. Results: Fifty-one patients developed pneumonia among 639 (7.98%) patients with COPD. Among 252 ICS-treated patients with COPD, 13 (5.16%) developed pneumonia, and among 387 ICS-untreated patients with COPD, 38 (9.82%) developed pneumonia. The mortality rate in ICS-treated patients with COPD was 7.7%, while that in ICS-untreated patients was 10.5% (P=0.767). Fluticasone/salmeterol use tended to show a higher risk of pneumonia than budesonide/formoterol use. The use of ICS did not increase the risk of pneumonia or mortality due to pneumonia in Japanese patients with COPD. Conclusion: ICS might not increase the risk of pneumonia in Japanese patients with COPD. In regard to pneumonia, ICS can be safely used in Japanese patients with COPD. Because there are apparent differences in lung diseases among races, appropriate treatment should be investigated in each country. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/30498340/Inhaled_corticosteroids_might_not_increase_the_risk_of_pneumonia_in_patients_with_chronic_obstructive_pulmonary_disease_in_Japan_ L2 - https://dx.doi.org/10.2147/COPD.S180349 DB - PRIME DP - Unbound Medicine ER -