Tags

Type your tag names separated by a space and hit enter

Improved Biosafety and Biosecurity Measures and/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks.
Int J Environ Res Public Health. 2018 11 29; 15(12)IJ

Abstract

Herein, we reviewed laboratory-acquired infections (LAIs) along with their health-related biological risks to provide an evidence base to tackle biosafety/biosecurity and biocontainment issues. Over the past years, a broad spectrum of pathogenic agents, such as bacteria, fungi, viruses, parasites, or genetically modified organisms, have been described and gained a substantial concern due to their profound biological as well as ecological risks. Furthermore, the emergence and/or re-emergence of life-threatening diseases are of supreme concern and come under the biosafety and biosecurity agenda to circumvent LAIs. Though the precise infection risk after an exposure remains uncertain, LAIs inspections revealed that Brucella spp., Mycobacterium tuberculosis, Salmonella spp., Shigella spp., Rickettsia spp., and Neisseria meningitidis are the leading causes. Similarly, the human immunodeficiency virus (HIV) as well as hepatitis B (HBV) and C viruses (HCV), and the dimorphic fungi are accountable for the utmost number of viral and fungal-associated LAIs. In this context, clinical laboratories at large and microbiology, mycology, bacteriology, and virology-oriented laboratories, in particular, necessitate appropriate biosafety and/or biosecurity measures to ensure the safety of laboratory workers and working environment, which are likely to have direct or indirect contact/exposure to hazardous materials or organisms. Laboratory staff education and training are indispensable to gain an adequate awareness to handle biologically hazardous materials as per internationally recognized strategies. In addition, workshops should be organized among laboratory workers to let them know the epidemiology, pathogenicity, and human susceptibility of LAIs. In this way, several health-related threats that result from the biologically hazardous materials can be abridged or minimized and controlled by the correct implementation of nationally and internationally certified protocols that include proper microbiological practices, containment devices/apparatus, satisfactory facilities or resources, protective barriers, and specialized education and training of laboratory staffs. The present work highlights this serious issue of LAIs and associated risks with suitable examples. Potential preventive strategies to tackle an array of causative agents are also discussed. In this respect, the researchers and scientific community may benefit from the lessons learned in the past to anticipate future problems.

Links

PMC Free PDF

Authors+Show Affiliations

Peng H
State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. hspeng@sjtu.edu.cn.
Bilal M
School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian 223003, China. bilaluaf@hotmail.com.
Iqbal HMN
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, CP 64849 Monterrey, N.L., Mexico. hafiz.iqbal@itesm.mx.

MeSH

Containment of BiohazardsHumansLaboratory InfectionLaboratory PersonnelMedical WasteOccupational DiseasesOccupational ExposurePersonal Protective EquipmentRisk AssessmentSafety Management

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30501091

Citation

Peng, Huasong, et al. "Improved Biosafety and Biosecurity Measures And/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks." International Journal of Environmental Research and Public Health, vol. 15, no. 12, 2018.
Peng H, Bilal M, Iqbal HMN. Improved Biosafety and Biosecurity Measures and/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks. Int J Environ Res Public Health. 2018;15(12).
Peng, H., Bilal, M., & Iqbal, H. M. N. (2018). Improved Biosafety and Biosecurity Measures and/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks. International Journal of Environmental Research and Public Health, 15(12). https://doi.org/10.3390/ijerph15122697
Peng H, Bilal M, Iqbal HMN. Improved Biosafety and Biosecurity Measures And/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks. Int J Environ Res Public Health. 2018 11 29;15(12) PubMed PMID: 30501091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved Biosafety and Biosecurity Measures and/or Strategies to Tackle Laboratory-Acquired Infections and Related Risks. AU - Peng,Huasong, AU - Bilal,Muhammad, AU - Iqbal,Hafiz M N, Y1 - 2018/11/29/ PY - 2018/10/23/received PY - 2018/11/16/revised PY - 2018/11/24/accepted PY - 2018/12/2/entrez PY - 2018/12/7/pubmed PY - 2019/4/19/medline KW - biohazards KW - biological risks KW - biosafety and biosecurity measures KW - laboratory-acquired infections KW - life-threatening diseases JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 15 IS - 12 N2 - Herein, we reviewed laboratory-acquired infections (LAIs) along with their health-related biological risks to provide an evidence base to tackle biosafety/biosecurity and biocontainment issues. Over the past years, a broad spectrum of pathogenic agents, such as bacteria, fungi, viruses, parasites, or genetically modified organisms, have been described and gained a substantial concern due to their profound biological as well as ecological risks. Furthermore, the emergence and/or re-emergence of life-threatening diseases are of supreme concern and come under the biosafety and biosecurity agenda to circumvent LAIs. Though the precise infection risk after an exposure remains uncertain, LAIs inspections revealed that Brucella spp., Mycobacterium tuberculosis, Salmonella spp., Shigella spp., Rickettsia spp., and Neisseria meningitidis are the leading causes. Similarly, the human immunodeficiency virus (HIV) as well as hepatitis B (HBV) and C viruses (HCV), and the dimorphic fungi are accountable for the utmost number of viral and fungal-associated LAIs. In this context, clinical laboratories at large and microbiology, mycology, bacteriology, and virology-oriented laboratories, in particular, necessitate appropriate biosafety and/or biosecurity measures to ensure the safety of laboratory workers and working environment, which are likely to have direct or indirect contact/exposure to hazardous materials or organisms. Laboratory staff education and training are indispensable to gain an adequate awareness to handle biologically hazardous materials as per internationally recognized strategies. In addition, workshops should be organized among laboratory workers to let them know the epidemiology, pathogenicity, and human susceptibility of LAIs. In this way, several health-related threats that result from the biologically hazardous materials can be abridged or minimized and controlled by the correct implementation of nationally and internationally certified protocols that include proper microbiological practices, containment devices/apparatus, satisfactory facilities or resources, protective barriers, and specialized education and training of laboratory staffs. The present work highlights this serious issue of LAIs and associated risks with suitable examples. Potential preventive strategies to tackle an array of causative agents are also discussed. In this respect, the researchers and scientific community may benefit from the lessons learned in the past to anticipate future problems. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/30501091/Improved_Biosafety_and_Biosecurity_Measures_and/or_Strategies_to_Tackle_Laboratory_Acquired_Infections_and_Related_Risks_ DB - PRIME DP - Unbound Medicine ER -