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Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS).
Water Res. 2019 02 01; 149:543-552.WR

Abstract

The frequent detection of propranolol, a widely used β-blocker, in wastewater effluents and surface waters has raised serious concern, due to its adverse effects on organisms. UV/hydrogen peroxide (UV/H2O2) and UV/persulfate (UV/PDS) processes are efficient in eliminating propranolol in various waters, but the formation of oxidation products in these processes, as well as the assessment of their toxicity, has not been systematically addressed. In this study, we identified and compared transformation products of propranolol produced by hydroxyl radical (•OH) and sulfate radical (SO4•-). The electrostatic attraction enhances the reaction between SO4•- and the protonated form of propranolol, while •OH shows non-selectivity toward both protonated and neutral propranolol species. The hydroxylation of propranolol by •OH occurs at either amine moiety or naphthalene group while SO4•- favors the oxidation of the electron-rich naphthalene group. Further oxidation by •OH and SO4•- results in ring-opening products. Bicarbonate and chloride exert no effect on propranolol degradation. The generation of CO3•- and Cl-containing radicals is favorable to oxidizing naphthalene group. The acute toxicity assay of Vibrio fischeri suggests that SO4•- generates more toxic products than •OH, while CO3•- and Cl-containing radicals produce similar toxicity as SO4•-. High concentrations of bicarbonate in UV/H2O2 increase the toxicity of treated solution.

Authors+Show Affiliations

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China. Electronic address: jiangjinhit@126.com.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China. Electronic address: xinglin.lu@yale.edu.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.School of Municipal and Environmental Engineering, Jilin Jianzhu University, Changchun, 130118, China.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.School of Environmental Science and Engineering, Beijing Forestry University, Beijing, 100083, China.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30502740

Citation

Yang, Yi, et al. "Comparative Study On Degradation of Propranolol and Formation of Oxidation Products By UV/H2O2 and UV/persulfate (PDS)." Water Research, vol. 149, 2019, pp. 543-552.
Yang Y, Cao Y, Jiang J, et al. Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS). Water Res. 2019;149:543-552.
Yang, Y., Cao, Y., Jiang, J., Lu, X., Ma, J., Pang, S., Li, J., Liu, Y., Zhou, Y., & Guan, C. (2019). Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS). Water Research, 149, 543-552. https://doi.org/10.1016/j.watres.2018.08.074
Yang Y, et al. Comparative Study On Degradation of Propranolol and Formation of Oxidation Products By UV/H2O2 and UV/persulfate (PDS). Water Res. 2019 02 1;149:543-552. PubMed PMID: 30502740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS). AU - Yang,Yi, AU - Cao,Ying, AU - Jiang,Jin, AU - Lu,Xinglin, AU - Ma,Jun, AU - Pang,Suyan, AU - Li,Juan, AU - Liu,Yongze, AU - Zhou,Yang, AU - Guan,Chaoting, Y1 - 2018/10/24/ PY - 2018/04/12/received PY - 2018/07/22/revised PY - 2018/08/31/accepted PY - 2018/12/5/pubmed PY - 2019/9/26/medline PY - 2018/12/4/entrez KW - Carbonate radical KW - Cl-containing radicals KW - Hydroxyl radical KW - Propranolol KW - Sulfate radical KW - Transformation products SP - 543 EP - 552 JF - Water research JO - Water Res. VL - 149 N2 - The frequent detection of propranolol, a widely used β-blocker, in wastewater effluents and surface waters has raised serious concern, due to its adverse effects on organisms. UV/hydrogen peroxide (UV/H2O2) and UV/persulfate (UV/PDS) processes are efficient in eliminating propranolol in various waters, but the formation of oxidation products in these processes, as well as the assessment of their toxicity, has not been systematically addressed. In this study, we identified and compared transformation products of propranolol produced by hydroxyl radical (•OH) and sulfate radical (SO4•-). The electrostatic attraction enhances the reaction between SO4•- and the protonated form of propranolol, while •OH shows non-selectivity toward both protonated and neutral propranolol species. The hydroxylation of propranolol by •OH occurs at either amine moiety or naphthalene group while SO4•- favors the oxidation of the electron-rich naphthalene group. Further oxidation by •OH and SO4•- results in ring-opening products. Bicarbonate and chloride exert no effect on propranolol degradation. The generation of CO3•- and Cl-containing radicals is favorable to oxidizing naphthalene group. The acute toxicity assay of Vibrio fischeri suggests that SO4•- generates more toxic products than •OH, while CO3•- and Cl-containing radicals produce similar toxicity as SO4•-. High concentrations of bicarbonate in UV/H2O2 increase the toxicity of treated solution. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/30502740/Comparative_study_on_degradation_of_propranolol_and_formation_of_oxidation_products_by_UV/H2O2_and_UV/persulfate__PDS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(18)30704-8 DB - PRIME DP - Unbound Medicine ER -