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Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms.
Vet Parasitol. 2018 Dec 15; 264:69-73.VP

Abstract

The aims of this study were to determine the species of Parascaris present in foals in Sweden and to establish whether anthelmintic resistance to pyrantel and fenbendazole is present on Swedish stud farms. Ascarid eggs collected from different regions in Sweden were karyotyped and were all identified as Parascaris univalens, characterized by one chromosomal pair. Faecal egg count reduction tests were performed on a total of 142 foals on 9 farms between September 2016 and May 2017. Healthy foals with at least 150 eggs per gram faeces (EPG) were included in the study and treated with oral pastes of pyrantel embonate or fenbendazole according to manufacturer instructions. The efficacy of the drugs was calculated by a Bayesian model using the R package "eggCounts". In accordance with the American Association of Equine Practitioners, parasites were classified as resistant to pyrantel if the reduction in EPG was ≤ 85% and to fenbendazole if the observed efficacy was ≤ 90%. Four of eleven groups treated with pyrantel had an observed efficacy of ≤ 85%, and as many as 43% of the foals treated with pyrantel excreted eggs 10-16 days after treatment. In contrast, one of the six groups treated with fenbendazole had an observed efficacy of ≤ 90%, and only 6% of all foals were excreting eggs 10-16 days after treatment. Since resistance to ivermectin has earlier been shown to be widespread in Parascaris spp. in Sweden it is likely that multiresistant populations are present on Swedish stud farms. This is the first study showing the existence of pyrantel-resistant Parascaris spp. in Europe, and the first ever study where anthelmintic resistance has been shown in P. univalens.

Authors+Show Affiliations

Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Parasitology, Uppsala, Sweden. Electronic address: Frida.martin@slu.se.Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Parasitology, Uppsala, Sweden.Swedish University of Agricultural Sciences, Department of Animal Genetics and Breeding, Uppsala, Sweden.Swedish University of Agricultural Sciences, Department of Molecular Sciences, Uppsala, Sweden.Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Parasitology, Uppsala, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30503095

Citation

Martin, Frida, et al. "Resistance to Pyrantel Embonate and Efficacy of Fenbendazole in Parascaris Univalens On Swedish Stud Farms." Veterinary Parasitology, vol. 264, 2018, pp. 69-73.
Martin F, Höglund J, Bergström TF, et al. Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms. Vet Parasitol. 2018;264:69-73.
Martin, F., Höglund, J., Bergström, T. F., Karlsson Lindsjö, O., & Tydén, E. (2018). Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms. Veterinary Parasitology, 264, 69-73. https://doi.org/10.1016/j.vetpar.2018.11.003
Martin F, et al. Resistance to Pyrantel Embonate and Efficacy of Fenbendazole in Parascaris Univalens On Swedish Stud Farms. Vet Parasitol. 2018 Dec 15;264:69-73. PubMed PMID: 30503095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms. AU - Martin,Frida, AU - Höglund,Johan, AU - Bergström,Tomas F, AU - Karlsson Lindsjö,Oskar, AU - Tydén,Eva, Y1 - 2018/11/10/ PY - 2018/09/23/received PY - 2018/11/07/revised PY - 2018/11/07/accepted PY - 2018/12/4/entrez PY - 2018/12/7/pubmed PY - 2018/12/19/medline KW - Anthelmintic resistance KW - Efficacy KW - Equine KW - Karyotype KW - Parascaris spp. KW - Pyrantel SP - 69 EP - 73 JF - Veterinary parasitology JO - Vet Parasitol VL - 264 N2 - The aims of this study were to determine the species of Parascaris present in foals in Sweden and to establish whether anthelmintic resistance to pyrantel and fenbendazole is present on Swedish stud farms. Ascarid eggs collected from different regions in Sweden were karyotyped and were all identified as Parascaris univalens, characterized by one chromosomal pair. Faecal egg count reduction tests were performed on a total of 142 foals on 9 farms between September 2016 and May 2017. Healthy foals with at least 150 eggs per gram faeces (EPG) were included in the study and treated with oral pastes of pyrantel embonate or fenbendazole according to manufacturer instructions. The efficacy of the drugs was calculated by a Bayesian model using the R package "eggCounts". In accordance with the American Association of Equine Practitioners, parasites were classified as resistant to pyrantel if the reduction in EPG was ≤ 85% and to fenbendazole if the observed efficacy was ≤ 90%. Four of eleven groups treated with pyrantel had an observed efficacy of ≤ 85%, and as many as 43% of the foals treated with pyrantel excreted eggs 10-16 days after treatment. In contrast, one of the six groups treated with fenbendazole had an observed efficacy of ≤ 90%, and only 6% of all foals were excreting eggs 10-16 days after treatment. Since resistance to ivermectin has earlier been shown to be widespread in Parascaris spp. in Sweden it is likely that multiresistant populations are present on Swedish stud farms. This is the first study showing the existence of pyrantel-resistant Parascaris spp. in Europe, and the first ever study where anthelmintic resistance has been shown in P. univalens. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/30503095/Resistance_to_pyrantel_embonate_and_efficacy_of_fenbendazole_in_Parascaris_univalens_on_Swedish_stud_farms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(18)30370-4 DB - PRIME DP - Unbound Medicine ER -