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Artopithecins A-D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities.
Chem Pharm Bull (Tokyo). 2018; 66(12):1199-1202.CP

Abstract

Four new prenylated 2-arylbenzofurans, namely artopithecins A-D (1-4), together with five known compounds (5-9) were isolated from the twigs of Artocarpus pithecogallus for the first time. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. All isolates were evaluated for their inhibitory activities against mushroom tyrosinase. Compounds 3 and 4 displayed significant tyrosinase inhibitory activities with IC50 values of 37.09±0.33 and 38.14±0.21 µM, respectively.

Authors+Show Affiliations

School of Pharmacy, Nanchang University.School of Pharmacy, Nanchang University.School of Pharmacy, Nanchang University.Key Laboratory Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM.Research Center of Natural Resources of Chinese Medicinal Materials and National Medicine, Jiangxi University of TCM.School of Pharmacy, Nanchang University.School of Pharmacy, Nanchang University.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30504634

Citation

Wang, Yong, et al. "Artopithecins A-D, Prenylated 2-Arylbenzofurans From the Twigs of Artocarpus Pithecogallus and Their Tyrosinase Inhibitory Activities." Chemical & Pharmaceutical Bulletin, vol. 66, no. 12, 2018, pp. 1199-1202.
Wang Y, Xu LY, Liu X, et al. Artopithecins A-D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities. Chem Pharm Bull (Tokyo). 2018;66(12):1199-1202.
Wang, Y., Xu, L. Y., Liu, X., He, X. R., Ren, G., Feng, L. H., & Zhou, Z. W. (2018). Artopithecins A-D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities. Chemical & Pharmaceutical Bulletin, 66(12), 1199-1202. https://doi.org/10.1248/cpb.c18-00523
Wang Y, et al. Artopithecins A-D, Prenylated 2-Arylbenzofurans From the Twigs of Artocarpus Pithecogallus and Their Tyrosinase Inhibitory Activities. Chem Pharm Bull (Tokyo). 2018;66(12):1199-1202. PubMed PMID: 30504634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Artopithecins A-D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities. AU - Wang,Yong, AU - Xu,Liu-Yun, AU - Liu,Xi, AU - He,Xiao-Ru, AU - Ren,Gang, AU - Feng,Li-Hua, AU - Zhou,Zhi-Wang, PY - 2018/12/4/entrez PY - 2018/12/7/pubmed PY - 2018/12/26/medline KW - Artocarpus pithecogallus KW - chalcone KW - prenylated 2-arylbenzofuran KW - prenylflavonoid KW - tyrosinase inhibitory activity SP - 1199 EP - 1202 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 66 IS - 12 N2 - Four new prenylated 2-arylbenzofurans, namely artopithecins A-D (1-4), together with five known compounds (5-9) were isolated from the twigs of Artocarpus pithecogallus for the first time. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. All isolates were evaluated for their inhibitory activities against mushroom tyrosinase. Compounds 3 and 4 displayed significant tyrosinase inhibitory activities with IC50 values of 37.09±0.33 and 38.14±0.21 µM, respectively. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/30504634/Artopithecins_A_D_Prenylated_2_Arylbenzofurans_from_the_Twigs_of_Artocarpus_pithecogallus_and_Their_Tyrosinase_Inhibitory_Activities_ L2 - https://doi.org/10.1248/cpb.c18-00523 DB - PRIME DP - Unbound Medicine ER -